Entity Details

Primary name PDE12_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ6L8Q7
EntryNamePDE12_HUMAN
FullName2',5'-phosphodiesterase 12
TaxID9606
Evidenceevidence at protein level
Length609
SequenceStatuscomplete
DateCreated2008-03-18
DateModified2021-06-02

Ontological Relatives

GenesPDE12

GO terms

Show/Hide Table
GOName
GO:0000175 3'-5'-exoribonuclease activity
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000958 mitochondrial mRNA catabolic process
GO:0004527 exonuclease activity
GO:0004535 poly(A)-specific ribonuclease activity
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0006397 mRNA processing
GO:0035457 cellular response to interferon-alpha
GO:0044528 regulation of mitochondrial mRNA stability
GO:0045070 positive regulation of viral genome replication
GO:0046872 metal ion binding
GO:0051607 defense response to virus
GO:0060548 negative regulation of cell death
GO:0071346 cellular response to interferon-gamma
GO:0071359 cellular response to dsRNA
GO:0090305 nucleic acid phosphodiester bond hydrolysis
GO:0090324 negative regulation of oxidative phosphorylation
GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic

Subcellular Location

Show/Hide Table
Subcellular Location
Mitochondrion matrix

Domains

Show/Hide Table
DomainNameCategoryType
IPR005135 Endonuclease/exonuclease/phosphataseDomainDomain
IPR036691 Endonuclease/exonuclease/phosphatase superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
PDE12_HUMANUBC_HUMANBioGRID16196087 23314748 28190767 details
PDE12_HUMANFBX7_HUMANBioGRID27503909 details