Entity Details

Primary name SULF1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8IWU6
EntryNameSULF1_HUMAN
FullNameExtracellular sulfatase Sulf-1
TaxID9606
Evidenceevidence at protein level
Length871
SequenceStatuscomplete
DateCreated2003-07-19
DateModified2021-06-02

Ontological Relatives

GenesSULF1

GO terms

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GOName
GO:0001822 kidney development
GO:0001937 negative regulation of endothelial cell proliferation
GO:0002063 chondrocyte development
GO:0003094 glomerular filtration
GO:0004065 arylsulfatase activity
GO:0005509 calcium ion binding
GO:0005539 glycosaminoglycan binding
GO:0005615 extracellular space
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005795 Golgi stack
GO:0005886 plasma membrane
GO:0006915 apoptotic process
GO:0008449 N-acetylglucosamine-6-sulfatase activity
GO:0009986 cell surface
GO:0010575 positive regulation of vascular endothelial growth factor production
GO:0014846 esophagus smooth muscle contraction
GO:0016525 negative regulation of angiogenesis
GO:0030177 positive regulation of Wnt signaling pathway
GO:0030201 heparan sulfate proteoglycan metabolic process
GO:0030336 negative regulation of cell migration
GO:0030513 positive regulation of BMP signaling pathway
GO:0032836 glomerular basement membrane development
GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway
GO:0040036 regulation of fibroblast growth factor receptor signaling pathway
GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway
GO:0045121 membrane raft
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048706 embryonic skeletal system development
GO:0051216 cartilage development
GO:0060348 bone development
GO:0060384 innervation
GO:0060686 negative regulation of prostatic bud formation

Subcellular Location

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Subcellular Location
Cell surface
Endoplasmic reticulum
Golgi apparatus

Domains

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DomainNameCategoryType
IPR000917 Sulfatase, N-terminalDomainDomain
IPR014615 Extracellular sulfataseFamilyFamily
IPR017850 Alkaline-phosphatase-like, core domain superfamilyFamilyHomologous superfamily
IPR024607 Sulfatase, conserved siteSiteConserved site
IPR024609 Extracellular sulfatase, C-terminalDomainDomain

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
SULF1_HUMANA4_HUMANBioGRID, IntAct21832049 28514442 details
SULF1_HUMANNEDD4_HUMANBioGRID19953087 details