Entity Details

Primary name TLR4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO00206
EntryNameTLR4_HUMAN
FullNameToll-like receptor 4
TaxID9606
Evidenceevidence at protein level
Length839
SequenceStatuscomplete
DateCreated2002-02-11
DateModified2021-06-02

Ontological Relatives

GenesTLR4

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0001530 lipopolysaccharide binding
GO:0001540 amyloid-beta binding
GO:0001726 ruffle
GO:0001875 lipopolysaccharide immune receptor activity
GO:0001891 phagocytic cup
GO:0002218 activation of innate immune response
GO:0002224 toll-like receptor signaling pathway
GO:0002322 B cell proliferation involved in immune response
GO:0002537 nitric oxide production involved in inflammatory response
GO:0002730 regulation of dendritic cell cytokine production
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0004888 transmembrane signaling receptor activity
GO:0005102 signaling receptor binding
GO:0005737 cytoplasm
GO:0005769 early endosome
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006909 phagocytosis
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007252 I-kappaB phosphorylation
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0010008 endosome membrane
GO:0010572 positive regulation of platelet activation
GO:0010628 positive regulation of gene expression
GO:0010838 positive regulation of keratinocyte proliferation
GO:0014002 astrocyte development
GO:0016046 detection of fungus
GO:0030890 positive regulation of B cell proliferation
GO:0031226 intrinsic component of plasma membrane
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032496 response to lipopolysaccharide
GO:0032497 detection of lipopolysaccharide
GO:0032689 negative regulation of interferon-gamma production
GO:0032700 negative regulation of interleukin-17 production
GO:0032707 negative regulation of interleukin-23 production
GO:0032715 negative regulation of interleukin-6 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032722 positive regulation of chemokine production
GO:0032727 positive regulation of interferon-alpha production
GO:0032728 positive regulation of interferon-beta production
GO:0032729 positive regulation of interferon-gamma production
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032732 positive regulation of interleukin-1 production
GO:0032733 positive regulation of interleukin-10 production
GO:0032735 positive regulation of interleukin-12 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0034128 negative regulation of MyD88-independent toll-like receptor signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0038023 signaling receptor activity
GO:0042088 T-helper 1 type immune response
GO:0042116 macrophage activation
GO:0042742 defense response to bacterium
GO:0042802 identical protein binding
GO:0043032 positive regulation of macrophage activation
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043235 receptor complex
GO:0045087 innate immune response
GO:0045348 positive regulation of MHC class II biosynthetic process
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045671 negative regulation of osteoclast differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046330 positive regulation of JNK cascade
GO:0046696 lipopolysaccharide receptor complex
GO:0046982 protein heterodimerization activity
GO:0048471 perinuclear region of cytoplasm
GO:0050135 NAD(P)+ nucleosidase activity
GO:0050729 positive regulation of inflammatory response
GO:0050829 defense response to Gram-negative bacterium
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process
GO:0060729 intestinal epithelial structure maintenance
GO:0060907 positive regulation of macrophage cytokine production
GO:0061809 NAD+ nucleotidase, cyclic ADP-ribose generating
GO:0070266 necroptotic process
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070430 positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070434 positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0071222 cellular response to lipopolysaccharide
GO:0071223 cellular response to lipoteichoic acid
GO:0071260 cellular response to mechanical stimulus
GO:0071346 cellular response to interferon-gamma
GO:0097190 apoptotic signaling pathway
GO:0120163 negative regulation of cold-induced thermogenesis
GO:0140052 cellular response to oxidised low-density lipoprotein particle stimulus
GO:1900017 positive regulation of cytokine production involved in inflammatory response
GO:1900227 positive regulation of NLRP3 inflammasome complex assembly
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1903223 positive regulation of oxidative stress-induced neuron death
GO:1903428 positive regulation of reactive oxygen species biosynthetic process
GO:1903974 positive regulation of cellular response to macrophage colony-stimulating factor stimulus
GO:1904466 positive regulation of matrix metallopeptidase secretion
GO:1904646 cellular response to amyloid-beta
GO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection
Early endosome

Domains

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DomainNameCategoryType
IPR000157 Toll/interleukin-1 receptor homology (TIR) domainDomainDomain
IPR000483 Cysteine-rich flanking region, C-terminalDomainDomain
IPR001611 Leucine-rich repeatRepeatRepeat
IPR003591 Leucine-rich repeat, typical subtypeRepeatRepeat
IPR017241 Toll-like receptorFamilyFamily
IPR032675 Leucine-rich repeat domain superfamilyFamilyHomologous superfamily
IPR035897 Toll/interleukin-1 receptor homology (TIR) domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00924 CyclobenzaprineDrugbanksmall molecule
DB01183 NaloxoneDrugbanksmall molecule
DB02767 (R)-3-hydroxytetradecanoic acidDrugbanksmall molecule
DB03017 Lauric acidDrugbanksmall molecule
DB04933 EritoranDrugbanksmall molecule
DB05475 GolotimodDrugbanksmall molecule
DB06447 E5531Drugbanksmall molecule
DB08231 Myristic acidDrugbanksmall molecule
DB11193 PapainDrugbanksmall molecule
DB13615 MifamurtideDrugbanksmall molecule

Interactions

61 interactions

InteractorPartnerSourcesPublicationsLink
TLR4_HUMANTIRAP_HUMANBioGRID, HPRD, IntAct11526399 11544529 17258210 18221795 20048342 21829704 21903422 details
TLR4_HUMANMYD88_HUMANBioGRID, HPRD, IntAct, MINT10952994 11743586 12646618 15107846 15728506 17126326 17258210 18221795 20048342 21829704 21911421 33052227 details
TLR4_HUMANLY96_HUMANBioGRID, DIP, HPRD, IntAct, UniProt10359581 11976338 15728506 17803912 19060881 19252480 20547845 22474354 22532668 details
TLR4_HUMANSMAD3_HUMANBioGRID, IntAct21988832 details
TLR4_HUMANSRTD1_HUMANBioGRID, IntAct21988832 details
TLR4_HUMANTCAM2_HUMANBioGRID, HPRD, IntAct14517278 14519765 14556004 17258210 18221795 21829704 21903422 25736436 31511519 details
TLR4_HUMANTLR4_HUMANDIP, IntAct, MINT22474354 23059983 23155421 details
TLR4_HUMANPGS1_HUMANmatrixdb24480070 details
TLR4_HUMANNOX4_HUMANHPRD, UniProt15356101 17064675 details
TLR4_HUMANTENA_HUMANIntAct29150600 details
TLR4_HUMANTENR_HUMANIntAct29150600 details
TLR4_HUMANTENN_HUMANIntAct29150600 details
TLR4_HUMANFIBG_HUMANIntAct29150600 details
TLR4_HUMANFCN1_HUMANIntAct29150600 details
TLR4_HUMANSIGL5_HUMANIntAct25187624 details
TLR4_HUMANSIGL6_HUMANIntAct25187624 details
TLR4_HUMANSIGL9_HUMANIntAct25187624 details
TLR4_HUMANSIGL7_HUMANIntAct25187624 details
TLR4_HUMANSIG11_HUMANIntAct25187624 details
TLR4_HUMANMBL2_HUMANIntAct21383675 details
TLR4_HUMANRN216_HUMANBioGRID, HPRD15107846 29740218 details
TLR4_HUMANTOLIP_HUMANBioGRID, HPRD11751856 details
TLR4_HUMANBTK_HUMANBioGRID, HPRD12724322 details
TLR4_HUMANUBQL1_HUMANBioGRID21695056 details
TLR4_HUMANEGFR_HUMANMINT17126326 details
TLR4_HUMANPAR2_HUMANUniProt18622013 details
TLR4_HUMANHMGB1_HUMANHPRD, MINT, UniProt16267105 20067962 20547845 details
TLR4_HUMANTLR6_HUMANIntAct20037584 details
TLR4_HUMANIRAK4_HUMANBioGRID, IntAct21220427 21829704 details
TLR4_HUMANPAQR1_HUMANMINT29190778 details
TLR4_HUMANSIGIR_HUMANBioGRID, HPRD12925853 details
TLR4_HUMANTLR1_HUMANBioGRID, HPRD11932926 details
TLR4_HUMANPP4C_HUMANBioGRID18634786 details
TLR4_HUMANCHIP_HUMANBioGRID21911421 details
TLR4_HUMANIRAK1_HUMANBioGRID, HPRD21911421 9625770 details
TLR4_HUMANTRI69_HUMANBioGRID21911421 details
TLR4_HUMANTBK1_HUMANBioGRID21911421 details
TLR4_HUMANTRAF6_HUMANBioGRID21911421 details
TLR4_HUMANHSP7C_HUMANBioGRID21911421 details
TLR4_HUMANSRC_HUMANBioGRID20379791 21911421 details
TLR4_HUMANKPCZ_HUMANBioGRID21911421 details
TLR4_HUMANHSP74_HUMANBioGRID22461698 details
TLR4_HUMANTCAM1_HUMANBioGRID19656901 25736436 31511519 details
TLR4_HUMANHGS_HUMANBioGRID16467847 details
TLR4_HUMANKSYK_HUMANBioGRID, HPRD14699155 23962979 details
TLR4_HUMANTNFL9_HUMANBioGRID24084649 details
TLR4_HUMANCAV1_HUMANBioGRID21715681 details
TLR4_HUMANBCAP_HUMANBioGRID27909057 details
TLR4_HUMANRFOX3_HUMANBioGRID29382328 details
TLR4_HUMANGFAP_HUMANBioGRID29382328 details
TLR4_HUMANTRI44_HUMANBioGRID30922374 details
TLR4_HUMANTRIL_HUMANBioGRID19710467 details
TLR4_HUMANENPL_HUMANHPRD11912201 details
TLR4_HUMANDFB4A_HUMANHPRD12411706 details
TLR4_HUMANTLR5_HUMANHPRD12794153 details
TLR4_HUMANIRAK2_HUMANHPRD9625770 details
TLR4_HUMANRIPK2_HUMANHPRD15691841 details
TLR4_HUMANBCL10_HUMANHPRD15213237 details
TLR4_HUMANJIP3_HUMANHPRD12941697 details
TLR4_HUMANCNPY4_HUMANHPRD16338228 details
TLR4_HUMANCD14_HUMANHPRD12196527 details