Entity Details

Primary name GRP4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8TDF6
EntryNameGRP4_HUMAN
FullNameRAS guanyl-releasing protein 4
TaxID9606
Evidenceevidence at protein level
Length673
SequenceStatuscomplete
DateCreated2008-01-15
DateModified2021-06-02

Ontological Relatives

GenesRASGRP4

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005509 calcium ion binding
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007264 small GTPase mediated signal transduction
GO:0008277 regulation of G protein-coupled receptor signaling pathway
GO:0008283 cell population proliferation
GO:0009991 response to extracellular stimulus
GO:0016020 membrane
GO:0019992 diacylglycerol binding
GO:0030099 myeloid cell differentiation
GO:0030742 GTP-dependent protein binding
GO:0046579 positive regulation of Ras protein signal transduction

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm

Domains

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DomainNameCategoryType
IPR000651 Ras-like guanine nucleotide exchange factor, N-terminalDomainDomain
IPR001895 Ras guanine-nucleotide exchange factors catalytic domainDomainDomain
IPR002048 EF-hand domainDomainDomain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domainDomainDomain
IPR008937 Ras-like guanine nucleotide exchange factorFamilyFamily
IPR020454 Diacylglycerol/phorbol-ester bindingDomainDomain
IPR023578 Ras guanine nucleotide exchange factor domain superfamilyFamilyHomologous superfamily
IPR036964 Ras guanine-nucleotide exchange factor, catalytic domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

6 interactions