Entity Details

Primary name HAVR2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8TDQ0
EntryNameHAVR2_HUMAN
FullNameHepatitis A virus cellular receptor 2
TaxID9606
Evidenceevidence at protein level
Length301
SequenceStatuscomplete
DateCreated2005-09-27
DateModified2021-06-02

Ontological Relatives

GenesHAVCR2

GO terms

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GOName
GO:0001772 immunological synapse
GO:0002250 adaptive immune response
GO:0002281 macrophage activation involved in immune response
GO:0002519 natural killer cell tolerance induction
GO:0002652 regulation of tolerance induction dependent upon immune response
GO:0002826 negative regulation of T-helper 1 type immune response
GO:0002859 negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
GO:0005769 early endosome
GO:0006954 inflammatory response
GO:0009986 cell surface
GO:0010629 negative regulation of gene expression
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0030886 negative regulation of myeloid dendritic cell activation
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032687 negative regulation of interferon-alpha production
GO:0032689 negative regulation of interferon-gamma production
GO:0032703 negative regulation of interleukin-2 production
GO:0032712 negative regulation of interleukin-3 production
GO:0032715 negative regulation of interleukin-6 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032722 positive regulation of chemokine production
GO:0032729 positive regulation of interferon-gamma production
GO:0032732 positive regulation of interleukin-1 production
GO:0032753 positive regulation of interleukin-4 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032815 negative regulation of natural killer cell activation
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034154 toll-like receptor 7 signaling pathway
GO:0034162 toll-like receptor 9 signaling pathway
GO:0042102 positive regulation of T cell proliferation
GO:0042130 negative regulation of T cell proliferation
GO:0043032 positive regulation of macrophage activation
GO:0045087 innate immune response
GO:0045089 positive regulation of innate immune response
GO:0046872 metal ion binding
GO:0050830 defense response to Gram-positive bacterium
GO:0060135 maternal process involved in female pregnancy
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071222 cellular response to lipopolysaccharide
GO:0071656 negative regulation of granulocyte colony-stimulating factor production
GO:1900425 negative regulation of defense response to bacterium
GO:1900426 positive regulation of defense response to bacterium
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:2000521 negative regulation of immunological synapse formation
GO:2001189 negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Membrane

Domains

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DomainNameCategoryType
IPR003599 Immunoglobulin subtypeDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR013106 Immunoglobulin V-set domainDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
618398 OMIMT-cell lymphoma, subcutaneous panniculitis-like (SPTCL)An uncommon form of T-cell non-Hodgkin lymphoma, in which cytotoxic CD8+ T-cells infiltrate subcutaneous adipose tissue, and rimming adipocytes in a lace-like pattern. Affected individuals typically present with multiple subcutaneous nodules, systemic B-cell symptoms, and, in a subset of cases, autoimmune disorders, most commonly systemic lupus erythematosus. A subset of patients develop hemophagocytic lymphohistiocytosis. SPTCL transmission pattern is consistent with autosomal recessive inheritance with incomplete penetrance. Disease susceptibility is associated with variants affecting the gene represented in this entry.