Entity Details

Primary name FRS2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8WU20
EntryNameFRS2_HUMAN
FullNameFibroblast growth factor receptor substrate 2
TaxID9606
Evidenceevidence at protein level
Length508
SequenceStatuscomplete
DateCreated2005-07-19
DateModified2021-06-02

Ontological Relatives

GenesFRS2

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000186 obsolete activation of MAPKK activity
GO:0000187 obsolete activation of MAPK activity
GO:0001702 gastrulation with mouth forming second
GO:0001759 organ induction
GO:0003281 ventricular septum development
GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005104 fibroblast growth factor receptor binding
GO:0005168 neurotrophin TRKA receptor binding
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005912 adherens junction
GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007405 neuroblast proliferation
GO:0007411 axon guidance
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0008595 anterior/posterior axis specification, embryo
GO:0012505 endomembrane system
GO:0016020 membrane
GO:0019211 phosphatase activator activity
GO:0030900 forebrain development
GO:0042981 regulation of apoptotic process
GO:0046619 lens placode formation involved in camera-type eye formation
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0050678 regulation of epithelial cell proliferation
GO:0051897 positive regulation of protein kinase B signaling
GO:0060527 prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0070307 lens fiber cell development
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:2000726 negative regulation of cardiac muscle cell differentiation

Subcellular Location

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Subcellular Location
Endomembrane system

Domains

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DomainNameCategoryType
IPR002404 IRS-type PTB domainDomainDomain
IPR038742 FRS2, PTB domainDomainDomain

Diseases

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Interactions

36 interactions

InteractorPartnerSourcesPublicationsLink
FRS2_HUMANPTN11_HUMANBioGRID, HPRD, IntAct, MINT10650943 11360177 11447289 12974390 16573649 22974441 25159185 29997244 9632781 details
FRS2_HUMANGRB2_HUMANBioGRID, HPRD, IntAct10092678 11997436 12402043 15004239 16893902 21706016 22974441 25159185 8780727 9182757 details
FRS2_HUMANFGFR1_HUMANBioGRID, HPRD, MINT10464310 10629055 11090629 11877385 18022941 21765395 9632781 9660748 details
FRS2_HUMANBECN1_HUMANBioGRID, IntAct25814554 details
FRS2_HUMANRS6_HUMANBioGRID, IntAct25814554 details
FRS2_HUMANINSR_HUMANBioGRID, HPRD10650943 details
FRS2_HUMANCBL_HUMANBioGRID, HPRD11997436 17944804 20038681 details
FRS2_HUMANCRK_HUMANBioGRID, HPRD10092678 12154000 details
FRS2_HUMANNTRK1_HUMANBioGRID, HPRD10092678 details
FRS2_HUMANNTRK2_HUMANBioGRID10092678 details
FRS2_HUMANNTRK3_HUMANBioGRID10092678 details
FRS2_HUMANRET_HUMANBioGRID, HPRD11360177 32062451 details
FRS2_HUMANKPCI_HUMANBioGRID, HPRD10383403 details
FRS2_HUMANFLOT1_HUMANBioGRID22235335 34079125 details
FRS2_HUMANSRBS1_HUMANBioGRID22235335 details
FRS2_HUMANMK03_HUMANBioGRID12974390 details
FRS2_HUMANMK01_HUMANBioGRID, HPRD12419216 12974390 32296183 details
FRS2_HUMANYJU2_HUMANBioGRID32296183 details
FRS2_HUMANPIN1_HUMANBioGRID32296183 details
FRS2_HUMANCDK3_HUMANBioGRID32296183 details
FRS2_HUMANKPCZ_HUMANHPRD10383403 details
FRS2_HUMANSOS1_HUMANBioGRID, HPRD10783152 11997436 16893902 9182757 9797459 details
FRS2_HUMANFGFR2_HUMANBioGRID15629145 21596750 details
FRS2_HUMANSPY2_HUMANBioGRID15004239 details
FRS2_HUMANGAB1_HUMANBioGRID, HPRD11353842 25159185 details
FRS2_HUMANGAB2_HUMANBioGRID25159185 details
FRS2_HUMANEPHA4_HUMANBioGRID16365308 details
FRS2_HUMANPGFRB_HUMANBioGRID19339244 details
FRS2_HUMANEGFR_HUMANBioGRID12974390 details
FRS2_HUMANPTPRF_HUMANHPRD10822386 details
FRS2_HUMANDDR1_HUMANHPRD10783152 details
FRS2_HUMANVGFR2_HUMANHPRD12154000 details
FRS2_HUMANSRC_HUMANHPRD10092678 details
FRS2_HUMANNCK1_HUMANHPRD12154000 details
FRS2_HUMANPAK1_HUMANHPRD12154000 details
FRS2_HUMANRND1_HUMANHPRD15738000 details