Entity Details

Primary name TOPB1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ92547
EntryNameTOPB1_HUMAN
FullNameDNA topoisomerase 2-binding protein 1
TaxID9606
Evidenceevidence at protein level
Length1522
SequenceStatuscomplete
DateCreated2005-04-26
DateModified2021-06-02

Ontological Relatives

GenesTOPBP1

GO terms

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GOName
GO:0000794 condensed nuclear chromosome
GO:0000922 spindle pole
GO:0001673 male germ cell nucleus
GO:0003677 DNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0005886 plasma membrane
GO:0006259 DNA metabolic process
GO:0006260 DNA replication
GO:0006270 DNA replication initiation
GO:0006281 DNA repair
GO:0006974 cellular response to DNA damage stimulus
GO:0007095 mitotic G2 DNA damage checkpoint signaling
GO:0008022 protein C-terminus binding
GO:0010212 response to ionizing radiation
GO:0015629 actin cytoskeleton
GO:0016604 nuclear body
GO:0016605 PML body
GO:0033314 mitotic DNA replication checkpoint signaling
GO:0042802 identical protein binding
GO:0043231 intracellular membrane-bounded organelle
GO:1901796 regulation of signal transduction by p53 class mediator

Subcellular Location

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Subcellular Location
Chromosome
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001357 BRCT domainDomainDomain
IPR035960 Secretoglobin superfamilyFamilyHomologous superfamily
IPR036420 BRCT domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

74 interactions

InteractorPartnerSourcesPublicationsLink
TOPB1_HUMANE2F1_HUMANBioGRID, HPRD, MINT12697828 14576432 14576433 17006541 20413589 28439015 details
TOPB1_HUMANTBCD4_HUMANHPRD, IntAct12421765 unassigned5 details
TOPB1_HUMANCSTN1_HUMANHPRD, IntAct12421765 unassigned5 details
TOPB1_HUMANAKT1_HUMANBioGRID, HPRD, MINT17006541 details
TOPB1_HUMANTOPB1_HUMANBioGRID, HPRD, MINT12773567 17006541 details
TOPB1_HUMANRAD9A_HUMANBioGRID, HPRD, MINT11395493 12941802 17006541 17575048 20545769 22925454 25091155 25602520 26088138 26312135 30295604 details
TOPB1_HUMANCDC45_HUMANBioGRID, IntAct17887956 20065034 details
TOPB1_HUMANZBT17_HUMANBioGRID, HPRD, MINT12408820 17006541 18923429 details
TOPB1_HUMANPP1G_HUMANBioGRID, IntAct21382349 details
TOPB1_HUMANMDC1_HUMANBioGRID, UniProt21482717 24239288 29656893 details
TOPB1_HUMANTCF20_HUMANBioGRID, UniProt17913746 details
TOPB1_HUMANKMT2A_HUMANUniProt17913746 details
TOPB1_HUMANKMT2D_HUMANUniProt17913746 details
TOPB1_HUMANKMT2B_HUMANUniProt17913746 details
TOPB1_HUMANESR1_HUMANBioGRID, IntAct20348541 31527615 details
TOPB1_HUMANTOP2B_HUMANBioGRID, HPRD9461304 details
TOPB1_HUMANUBR5_HUMANBioGRID, HPRD11714696 details
TOPB1_HUMANABL1_HUMANBioGRID15961388 details
TOPB1_HUMANFANCJ_HUMANBioGRID16391231 20159562 21127055 23157317 24573678 30295604 33010150 details
TOPB1_HUMANATM_HUMANBioGRID, HPRD11756551 19023333 details
TOPB1_HUMANCHK1_HUMANBioGRID17686975 details
TOPB1_HUMANTICRR_HUMANBioGRID21700459 23704573 28439015 30295604 30695077 details
TOPB1_HUMANBLM_HUMANBioGRID24239288 30295604 details
TOPB1_HUMANRHNO1_HUMANBioGRID21659603 25602520 30295604 details
TOPB1_HUMANPSF1_HUMANBioGRID23629628 details
TOPB1_HUMANPPHLN_HUMANBioGRID21466675 details
TOPB1_HUMANSMRCD_HUMANBioGRID28063255 details
TOPB1_HUMANCTIP_HUMANBioGRID30217970 details
TOPB1_HUMANTEX11_HUMANBioGRID30217970 details
TOPB1_HUMANFHL3_HUMANBioGRID30217970 details
TOPB1_HUMANSF3B2_HUMANBioGRID30217970 details
TOPB1_HUMANRAI1_HUMANBioGRID17913746 details
TOPB1_HUMANMUTYH_HUMANBioGRID26312135 details
TOPB1_HUMANPARP1_HUMANBioGRID17340632 34079125 details
TOPB1_HUMANHUS1_HUMANBioGRID20545769 details
TOPB1_HUMANRAD1_HUMANBioGRID20545769 details
TOPB1_HUMANPHF8_HUMANBioGRID33010150 details
TOPB1_HUMANCIP2A_HUMANBioGRID34145035 details
TOPB1_HUMANTOP1_HUMANMINT17006541 details
TOPB1_HUMANPIAS2_HUMANMINT17006541 details
TOPB1_HUMANUBC_HUMANMINT18923429 details
TOPB1_HUMANTP53B_HUMANBioGRID, MINT, UniProt11756551 20871591 29656893 details
TOPB1_HUMANATRIP_HUMANBioGRID, MINT17616665 20871591 details
TOPB1_HUMANPLK1_HUMANBioGRID, IntAct26186194 26811421 28514442 details
TOPB1_HUMANBRCA1_HUMANBioGRID, UniProt16391231 19766185 23157317 23901102 25184681 29656893 33010150 details
TOPB1_HUMANPML_HUMANBioGRID, HPRD12773567 19023333 details
TOPB1_HUMANDPOE1_HUMANBioGRID, HPRD11395493 details
TOPB1_HUMANMSH6_HUMANBioGRID20029092 details
TOPB1_HUMANPMS2_HUMANBioGRID20029092 details
TOPB1_HUMANATR_HUMANBioGRID19097996 28439015 details
TOPB1_HUMANRFA1_HUMANBioGRID20159562 details
TOPB1_HUMANSMCA4_HUMANBioGRID20571081 details
TOPB1_HUMANNBN_HUMANBioGRID17765870 details
TOPB1_HUMANBARD1_HUMANBioGRID16391231 details
TOPB1_HUMANDTD1_HUMANBioGRID20065034 details
TOPB1_HUMANHSP7C_HUMANBioGRID24239288 details
TOPB1_HUMANBIP_HUMANBioGRID24239288 details
TOPB1_HUMANACTG_HUMANBioGRID24239288 details
TOPB1_HUMANH4_HUMANBioGRID24239288 30804502 details
TOPB1_HUMANDDB1_HUMANBioGRID24239288 details
TOPB1_HUMANDCAF1_HUMANBioGRID24239288 details
TOPB1_HUMANSMC4_HUMANBioGRID24239288 details
TOPB1_HUMANRMI1_HUMANBioGRID24239288 details
TOPB1_HUMANSLX4_HUMANBioGRID25030699 31495888 details
TOPB1_HUMANTELO2_HUMANBioGRID19097996 details
TOPB1_HUMANP53_HUMANBioGRID28439015 29653964 31570706 details
TOPB1_HUMANMTBP_HUMANBioGRID23704573 30695077 details
TOPB1_HUMANMCPH1_HUMANBioGRID25301947 details
TOPB1_HUMANRAD51_HUMANBioGRID26811421 details
TOPB1_HUMANCDK8_HUMANBioGRID30695077 details
TOPB1_HUMANPDCD4_HUMANBioGRID29395067 details
TOPB1_HUMANSET_HUMANBioGRID33010150 details
TOPB1_HUMANBMPR2_HUMANHPRD15188402 details
TOPB1_HUMANTCFL5_HUMANHPRD17006541 details