Entity Details

Primary name AP2M1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ96CW1
EntryNameAP2M1_HUMAN
FullNameAP-2 complex subunit mu
TaxID9606
Evidenceevidence at protein level
Length435
SequenceStatuscomplete
DateCreated2004-08-16
DateModified2021-06-02

Ontological Relatives

GenesAP2M1

GO terms

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GOName
GO:0005048 signal sequence binding
GO:0005765 lysosomal membrane
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005905 clathrin-coated pit
GO:0006886 intracellular protein transport
GO:0006897 endocytosis
GO:0006900 vesicle budding from membrane
GO:0008289 lipid binding
GO:0016192 vesicle-mediated transport
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0030122 AP-2 adaptor complex
GO:0030666 endocytic vesicle membrane
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:0031623 receptor internalization
GO:0032802 low-density lipoprotein particle receptor catabolic process
GO:0034383 low-density lipoprotein particle clearance
GO:0034622 cellular protein-containing complex assembly
GO:0035615 clathrin adaptor activity
GO:0036020 endolysosome membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0044325 transmembrane transporter binding
GO:0045334 clathrin-coated endocytic vesicle
GO:0048013 ephrin receptor signaling pathway
GO:0050690 regulation of defense response to virus by virus
GO:0050750 low-density lipoprotein particle receptor binding
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0061024 membrane organization
GO:0070062 extracellular exosome
GO:0072583 clathrin-dependent endocytosis
GO:0097494 regulation of vesicle size
GO:1903077 negative regulation of protein localization to plasma membrane

Subcellular Location

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Subcellular Location
Cell membrane
Membrane

Domains

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DomainNameCategoryType
IPR001392 Clathrin adaptor, mu subunitFamilyFamily
IPR011012 Longin-like domain superfamilyFamilyHomologous superfamily
IPR018240 Clathrin adaptor, mu subunit, conserved siteSiteConserved site
IPR022775 AP complex, mu/sigma subunitDomainDomain
IPR028565 Mu homology domainDomainDomain
IPR036168 AP-2 complex subunit mu, C-terminal superfamilyFamilyHomologous superfamily
IPR043512 Mu2, C-terminal domainDomainDomain
IPR043532 AP-2 complex subunit mu, N-terminalDomainDomain

Diseases

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Disease IDSourceNameDescription
618587 OMIMIntellectual developmental disorder, autosomal dominant 60, with seizures (MRD60)An autosomal dominant disorder characterized by global developmental delay apparent in the first six months of life, followed by onset of seizures between 21 months and 4 years. Disease features include moderate-to-severe intellectual disability, poor speech, delayed walking, and ataxia. The disease is caused by variants affecting the gene represented in this entry.

Interactions

109 interactions

InteractorPartnerSourcesPublicationsLink
AP2M1_HUMANRBP1_HUMANBioGRID, HPRD, IntAct, MINT10910768 26186194 28514442 details
AP2M1_HUMANRRP12_HUMANBioGRID, HPRD, IntAct12421765 details
AP2M1_HUMANMEG10_HUMANBioGRID, HPRD, IntAct12421765 17643423 details
AP2M1_HUMANFXR2_HUMANBioGRID, HPRD, IntAct16189514 31515488 details
AP2M1_HUMANDVL2_HUMANBioGRID, HPRD, IntAct16189514 31340145 31515488 details
AP2M1_HUMANMED4_HUMANBioGRID, HPRD, IntAct16189514 details
AP2M1_HUMANIKZF1_HUMANBioGRID, HPRD, IntAct16189514 details
AP2M1_HUMANZBT8A_HUMANBioGRID, IntAct16189514 details
AP2M1_HUMANRUN3A_HUMANBioGRID, HPRD, IntAct16189514 28514442 details
AP2M1_HUMANRSP14_HUMANBioGRID, HPRD, IntAct16189514 32296183 details
AP2M1_HUMANDPPA2_HUMANBioGRID, HPRD, IntAct16189514 details
AP2M1_HUMANTBCD5_HUMANBioGRID, HPRD, IntAct, MINT16189514 24603492 31515488 details
AP2M1_HUMANAP2B1_HUMANBioGRID, HPRD, IntAct12086608 16189514 19380743 24189400 26186194 26344197 28514442 30021884 34079125 details
AP2M1_HUMANCAC1A_HUMANBioGRID, IntAct21078624 details
AP2M1_HUMANCD11B_HUMANBioGRID, IntAct21988832 details
AP2M1_HUMANRL38_HUMANBioGRID, IntAct21988832 details
AP2M1_HUMANCSK2B_HUMANBioGRID, IntAct21988832 details
AP2M1_HUMANTASOR_HUMANBioGRID, IntAct21988832 details
AP2M1_HUMANEGFR_HUMANBioGRID, IntAct20029029 23956138 24067654 24189400 24797263 25754235 31959764 31980649 details
AP2M1_HUMANAP1B1_HUMANBioGRID, IntAct19380743 24189400 26186194 26344197 28514442 7593184 details
AP2M1_HUMANUBC_HUMANBioGRID, IntAct19380743 24189400 28190767 details
AP2M1_HUMANSFRP4_HUMANBioGRID, MINT24412244 details
AP2M1_HUMANH2B1C_HUMANBioGRID, IntAct32296183 details
AP2M1_HUMANPR38A_HUMANBioGRID, IntAct32296183 details
AP2M1_HUMANF90A1_HUMANBioGRID, IntAct32296183 details
AP2M1_HUMANRL22_HUMANBioGRID, IntAct32296183 details
AP2M1_HUMANEM55_HUMANBioGRID, IntAct32296183 details
AP2M1_HUMANNAA11_HUMANBioGRID, IntAct32296183 details
AP2M1_HUMANEAF1_HUMANBioGRID, IntAct32296183 details
AP2M1_HUMANPRR13_HUMANBioGRID, IntAct32296183 details
AP2M1_HUMANMB213_HUMANBioGRID, IntAct32296183 details
AP2M1_HUMANTMA16_HUMANBioGRID, IntAct32296183 details
AP2M1_HUMANCX05B_HUMANBioGRID, IntAct32296183 details
AP2M1_HUMANZN581_HUMANBioGRID, IntAct32296183 details
AP2M1_HUMANKNOP1_HUMANBioGRID, IntAct32296183 details
AP2M1_HUMANUTP25_HUMANBioGRID, IntAct26186194 28514442 32296183 details
AP2M1_HUMANHEXI2_HUMANBioGRID, IntAct32296183 details
AP2M1_HUMANH2B1L_HUMANBioGRID, IntAct32296183 details
AP2M1_HUMANPTPS_HUMANBioGRID, IntAct32296183 details
AP2M1_HUMANPRP18_HUMANBioGRID, IntAct32296183 details
AP2M1_HUMANMMTA2_HUMANBioGRID, IntAct32296183 details
AP2M1_HUMANMTURN_HUMANBioGRID, IntAct32296183 details
AP2M1_HUMANH2B2E_HUMANBioGRID, IntAct32296183 details
AP2M1_HUMANNKAP1_HUMANBioGRID, IntAct32296183 details
AP2M1_HUMANMFAP1_HUMANBioGRID, IntAct32296183 details
AP2M1_HUMANEIF1A_HUMANBioGRID, IntAct32296183 details
AP2M1_HUMANCD5_HUMANIntAct14707061 details
AP2M1_HUMANSTON2_HUMANBioGRID, IntAct11454741 19380743 26186194 28514442 details
AP2M1_HUMANSYNJ1_HUMANBioGRID, IntAct12057195 26186194 28514442 details
AP2M1_HUMANTGON2_HUMANBioGRID, HPRD, IntAct10814565 15254094 15916959 29568061 details
AP2M1_HUMANAGTR1_HUMANBioGRID, MINT28298427 details
AP2M1_HUMANBKRB2_HUMANBioGRID, MINT28298427 details
AP2M1_HUMAN5HT6R_HUMANBioGRID, MINT28298427 details
AP2M1_HUMANLT4R2_HUMANBioGRID, MINT28298427 details
AP2M1_HUMANLY9_HUMANBioGRID, HPRD12621057 details
AP2M1_HUMANEHD2_HUMANBioGRID, HPRD15182197 details
AP2M1_HUMANCD22_HUMANBioGRID, HPRD12646615 details
AP2M1_HUMANADA1B_HUMANBioGRID, HPRD12644451 details
AP2M1_HUMANCTLA4_HUMANBioGRID, HPRD11583591 9200449 9256472 9812899 details
AP2M1_HUMANAQP4_HUMANBioGRID, HPRD11742978 details
AP2M1_HUMANFURIN_HUMANBioGRID, HPRD10593987 details
AP2M1_HUMANNCOR2_HUMANBioGRID15604093 details
AP2M1_HUMANATX1L_HUMANBioGRID16713569 details
AP2M1_HUMANGLP1R_HUMANBioGRID23864651 details
AP2M1_HUMANCORO7_HUMANBioGRID16905771 details
AP2M1_HUMANRN111_HUMANBioGRID32296183 details
AP2M1_HUMANCX05A_HUMANBioGRID32296183 details
AP2M1_HUMANNMDE1_HUMANBioGRID15254094 details
AP2M1_HUMANNMDE2_HUMANBioGRID, HPRD15254094 details
AP2M1_HUMANLAMP1_HUMANBioGRID, HPRD34079125 7569928 details
AP2M1_HUMANCD3D_HUMANHPRD15778375 details
AP2M1_HUMANDCX_HUMANHPRD11591131 details
AP2M1_HUMANAP2M1_HUMANBioGRID, HPRD, IntAct11583591 19380743 24189400 9812899 details
AP2M1_HUMANTMM59_HUMANMINT23376921 details
AP2M1_HUMANATG9A_HUMANBioGRID, MINT24603492 27934868 details
AP2M1_HUMANGAK_HUMANBioGRID, HPRD, IntAct10887964 12010461 26496610 details
AP2M1_HUMANOCRL_HUMANBioGRID, IntAct, MINT25107275 27173435 unassigned1312 details
AP2M1_HUMANAP1G1_HUMANBioGRID, IntAct10747088 26186194 28514442 7593184 details
AP2M1_HUMANFMR1_HUMANIntAct31413325 details
AP2M1_HUMANFXR1_HUMANBioGRID, MINT21653829 29395067 details
AP2M1_HUMANCLC4M_HUMANBioGRID12621057 details
AP2M1_HUMANINAR1_HUMANBioGRID18056411 18474601 details
AP2M1_HUMANA16L1_HUMANBioGRID20639872 30196744 details
AP2M1_HUMANARRB2_HUMANBioGRID, HPRD17666399 17984062 details
AP2M1_HUMANTBB5_HUMANBioGRID19380743 24189400 details
AP2M1_HUMANHSP7C_HUMANBioGRID19380743 24189400 details
AP2M1_HUMANHS71A_HUMANBioGRID19380743 24189400 details
AP2M1_HUMANHS71B_HUMANBioGRID19380743 24189400 details
AP2M1_HUMANDAB2_HUMANBioGRID, HPRD11247302 22323290 details
AP2M1_HUMANKCNQ1_HUMANBioGRID23529131 details
AP2M1_HUMANRNF11_HUMANBioGRID23751493 details
AP2M1_HUMANEPHA2_HUMANBioGRID23874206 details
AP2M1_HUMANADT1_HUMANBioGRID24189400 details
AP2M1_HUMANADT2_HUMANBioGRID24189400 details
AP2M1_HUMANADT3_HUMANBioGRID24189400 details
AP2M1_HUMANATX2L_HUMANBioGRID24189400 details
AP2M1_HUMANGFAP_HUMANBioGRID24189400 details
AP2M1_HUMANTBA1B_HUMANBioGRID24189400 details
AP2M1_HUMANMYO6_HUMANBioGRID26950368 details
AP2M1_HUMANMEX3C_HUMANBioGRID28982131 details
AP2M1_HUMANAP2A_HUMANBioGRID12900408 details
AP2M1_HUMANMLP3A_HUMANBioGRID24067654 details
AP2M1_HUMANMRP2_HUMANBioGRID31316180 details
AP2M1_HUMANMEX3B_HUMANBioGRID29395067 details
AP2M1_HUMANPATL1_HUMANBioGRID29395067 details
AP2M1_HUMANTNR6A_HUMANBioGRID29395067 details
AP2M1_HUMANTNR6B_HUMANBioGRID29395067 details
AP2M1_HUMANTNR6C_HUMANBioGRID29395067 details
AP2M1_HUMANISG15_HUMANBioGRID33024031 details