Entity Details

Primary name MOCOS_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ96EN8
EntryNameMOCOS_HUMAN
FullNameMolybdenum cofactor sulfurase
TaxID9606
Evidenceevidence at protein level
Length888
SequenceStatuscomplete
DateCreated2006-09-19
DateModified2021-06-02

Ontological Relatives

GenesMOCOS

GO terms

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GOName
GO:0005829 cytosol
GO:0006777 Mo-molybdopterin cofactor biosynthetic process
GO:0008265 Mo-molybdopterin cofactor sulfurase activity
GO:0016829 lyase activity
GO:0030151 molybdenum ion binding
GO:0030170 pyridoxal phosphate binding
GO:0032324 molybdopterin cofactor biosynthetic process
GO:0043545 molybdopterin cofactor metabolic process
GO:0102867 molybdenum cofactor sulfurtransferase activity

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000192 Aminotransferase class V domainDomainDomain
IPR005302 Molybdenum cofactor sulfurase, C-terminalDomainDomain
IPR005303 MOSC, N-terminal beta barrelDomainDomain
IPR011037 Pyruvate kinase-like, insert domain superfamilyFamilyHomologous superfamily
IPR015421 Pyridoxal phosphate-dependent transferase, major domainFamilyHomologous superfamily
IPR015422 Pyridoxal phosphate-dependent transferase, small domainFamilyHomologous superfamily
IPR015424 Pyridoxal phosphate-dependent transferaseFamilyHomologous superfamily
IPR028886 Molybdenum cofactor sulfuraseFamilyFamily

Diseases

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Disease IDSourceNameDescription
603592 OMIMXanthinuria 2 (XAN2)A disorder characterized by excretion of very large amounts of xanthine in the urine and a tendency to form xanthine stones. Uric acid is strikingly diminished in serum and urine. In addition, XAN2 patients cannot metabolize allopurinol into oxypurinol due to dual deficiency of xanthine dehydrogenase and aldehyde oxidase. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00114 Pyridoxal phosphateDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
MOCOS_HUMANPARVA_HUMANBioGRID, IntAct, MINT21516116 25416956 26186194 28514442 details
MOCOS_HUMANARL8A_HUMANBioGRID, IntAct32296183 details