Entity Details

Primary name EGLN2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ96KS0
EntryNameEGLN2_HUMAN
FullNameProlyl hydroxylase EGLN2
TaxID9606
Evidenceevidence at protein level
Length407
SequenceStatuscomplete
DateCreated2003-06-16
DateModified2021-06-02

Ontological Relatives

GenesEGLN2

GO terms

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GOName
GO:0001558 regulation of cell growth
GO:0001666 response to hypoxia
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0008198 ferrous iron binding
GO:0016706 2-oxoglutarate-dependent dioxygenase activity
GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline
GO:0019826 oxygen sensor activity
GO:0030520 intracellular estrogen receptor signaling pathway
GO:0031418 L-ascorbic acid binding
GO:0031543 peptidyl-proline dioxygenase activity
GO:0031545 peptidyl-proline 4-dioxygenase activity
GO:0043523 regulation of neuron apoptotic process
GO:0045454 cell redox homeostasis
GO:0045732 positive regulation of protein catabolic process
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0071456 cellular response to hypoxia

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR005123 Oxoglutarate/iron-dependent dioxygenaseDomainDomain
IPR006620 Prolyl 4-hydroxylase, alpha subunitDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00126 Ascorbic acidDrugbanksmall molecule
DB04847 RoxadustatDrugbanksmall molecule

Interactions

34 interactions

InteractorPartnerSourcesPublicationsLink
EGLN2_HUMANHIF1A_HUMANBioGRID, HPRD, IntAct, MINT11292861 11292862 15474027 16155211 16511565 17353276 18264140 26644182 details
EGLN2_HUMANPHOCN_HUMANHPRD, IntAct16169070 details
EGLN2_HUMANSRPK2_HUMANBioGRID, IntAct23602568 details
EGLN2_HUMANEPAS1_HUMANBioGRID, HPRD, IntAct15474027 17353276 23275444 details
EGLN2_HUMANMFHA1_HUMANBioGRID, IntAct29513927 details
EGLN2_HUMANPCNA_HUMANUniProt26030842 details
EGLN2_HUMANA2MG_HUMANBioGRID21163940 details
EGLN2_HUMANTET5A_HUMANBioGRID, HPRD15231748 details
EGLN2_HUMANSPOP_HUMANBioGRID28089830 details
EGLN2_HUMANATF4_HUMANBioGRID21951999 details
EGLN2_HUMANCDK2_HUMANBioGRID26644182 details
EGLN2_HUMANKPCA_HUMANBioGRID18710826 details
EGLN2_HUMANRPB1_HUMANBioGRID18285459 details
EGLN2_HUMANSIAH2_HUMANBioGRID15210114 16958618 details
EGLN2_HUMANEGLN3_HUMANBioGRID16958618 details
EGLN2_HUMANEGLN2_HUMANBioGRID16958618 details
EGLN2_HUMANPRP19_HUMANBioGRID20599946 details
EGLN2_HUMANSPY2_HUMANBioGRID22006925 details
EGLN2_HUMANLIMD1_HUMANBioGRID22286099 details
EGLN2_HUMANAJUBA_HUMANBioGRID22286099 details
EGLN2_HUMANWTIP_HUMANBioGRID22286099 details
EGLN2_HUMANTRIP6_HUMANBioGRID22286099 details
EGLN2_HUMANLPP_HUMANBioGRID22286099 details
EGLN2_HUMANMAGAB_HUMANBioGRID19147576 details
EGLN2_HUMANCE192_HUMANBioGRID23932902 26644182 details
EGLN2_HUMANDYR1A_HUMANBioGRID26735018 details
EGLN2_HUMANDYR1B_HUMANBioGRID26735018 details
EGLN2_HUMANCUL3_HUMANBioGRID28089830 details
EGLN2_HUMANFBXW7_HUMANBioGRID28036276 details
EGLN2_HUMANCDK4_HUMANBioGRID26644182 details
EGLN2_HUMANCDK6_HUMANBioGRID26644182 details
EGLN2_HUMANRUNX3_HUMANBioGRID23542169 details
EGLN2_HUMANBRD4_HUMANBioGRID31239290 details
EGLN2_HUMANHIF3A_HUMANHPRD15474027 details