Entity Details

Primary name GBP5_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ96PP8
EntryNameGBP5_HUMAN
FullNameGuanylate-binding protein 5
TaxID9606
Evidenceevidence at protein level
Length586
SequenceStatuscomplete
DateCreated2003-10-24
DateModified2021-06-02

Ontological Relatives

GenesGBP5

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0006954 inflammatory response
GO:0016020 membrane
GO:0031410 cytoplasmic vesicle
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032741 positive regulation of interleukin-18 production
GO:0034067 protein localization to Golgi apparatus
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0045089 positive regulation of innate immune response
GO:0048471 perinuclear region of cytoplasm
GO:0051289 protein homotetramerization
GO:0071346 cellular response to interferon-gamma
GO:1900017 positive regulation of cytokine production involved in inflammatory response
GO:1900227 positive regulation of NLRP3 inflammasome complex assembly

Subcellular Location

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Subcellular Location
Cytoplasm
Golgi apparatus membrane

Domains

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DomainNameCategoryType
IPR003191 Guanylate-binding protein/Atlastin, C-terminalDomainDomain
IPR015894 Guanylate-binding protein, N-terminalDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR030386 GB1/RHD3-type guanine nucleotide-binding (G) domainDomainDomain
IPR036543 Guanylate-binding protein, C-terminal domain superfamilyFamilyHomologous superfamily
IPR037684 Guanylate-binding protein, C-terminalDomainDomain

Diseases

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Interactions

6 interactions