Entity Details

Primary name ARHGA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO15013
EntryNameARHGA_HUMAN
FullNameRho guanine nucleotide exchange factor 10
TaxID9606
Evidenceevidence at protein level
Length1369
SequenceStatuscomplete
DateCreated2004-07-05
DateModified2021-06-02

Ontological Relatives

GenesARHGEF10

GO terms

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GOName
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005813 centrosome
GO:0005829 cytosol
GO:0019894 kinesin binding
GO:0022011 myelination in peripheral nervous system
GO:0030036 actin cytoskeleton organization
GO:0035023 regulation of Rho protein signal transduction
GO:0051298 centrosome duplication
GO:0051496 positive regulation of stress fiber assembly
GO:0090307 mitotic spindle assembly
GO:0090630 activation of GTPase activity

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000219 Dbl homology (DH) domainDomainDomain
IPR015943 WD40/YVTN repeat-like-containing domain superfamilyFamilyHomologous superfamily
IPR030632 Rho guanine nucleotide exchange factor 10FamilyFamily
IPR035899 Dbl homology (DH) domain superfamilyFamilyHomologous superfamily
IPR036322 WD40-repeat-containing domain superfamilyFamilyHomologous superfamily
IPR039919 Rho guanine nucleotide exchange factor 10/17FamilyFamily

Diseases

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Disease IDSourceNameDescription
608236 OMIMSlowed nerve conduction velocity (SNCV)Affected individuals present a reduction in nerve conduction velocities without any clinical signs of peripheral or central nervous system dysfunction. SNCV inheritance is autosomal dominant. The disease is caused by variants affecting the gene represented in this entry.