Entity Details

Primary name TRIB1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ96RU8
EntryNameTRIB1_HUMAN
FullNameTribbles homolog 1
TaxID9606
Evidenceevidence at protein level
Length372
SequenceStatuscomplete
DateCreated2005-12-06
DateModified2021-06-02

Ontological Relatives

GenesTRIB1

GO terms

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GOName
GO:0004860 protein kinase inhibitor activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006468 protein phosphorylation
GO:0006469 negative regulation of protein kinase activity
GO:0007254 JNK cascade
GO:0008134 transcription factor binding
GO:0014912 negative regulation of smooth muscle cell migration
GO:0031434 mitogen-activated protein kinase kinase binding
GO:0031625 ubiquitin protein ligase binding
GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032496 response to lipopolysaccharide
GO:0043405 regulation of MAP kinase activity
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0045645 positive regulation of eosinophil differentiation
GO:0045651 positive regulation of macrophage differentiation
GO:0045659 negative regulation of neutrophil differentiation
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0055106 ubiquitin-protein transferase regulator activity

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR024104 Pseudokinase tribbles family/serine-threonine-protein kinase 40FamilyFamily
IPR024105 Tribbles homologue 1FamilyFamily

Diseases

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