Entity Details

Primary name CK5P2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ96SN8
EntryNameCK5P2_HUMAN
FullNameCDK5 regulatory subunit-associated protein 2
TaxID9606
Evidenceevidence at protein level
Length1893
SequenceStatuscomplete
DateCreated2003-06-16
DateModified2021-06-02

Ontological Relatives

GenesCDK5RAP2

GO terms

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GOName
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000132 establishment of mitotic spindle orientation
GO:0000226 microtubule cytoskeleton organization
GO:0000242 pericentriolar material
GO:0000922 spindle pole
GO:0000976 transcription cis-regulatory region binding
GO:0001578 microtubule bundle formation
GO:0005516 calmodulin binding
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0007059 chromosome segregation
GO:0007098 centrosome cycle
GO:0007099 centriole replication
GO:0007420 brain development
GO:0008017 microtubule binding
GO:0010389 regulation of G2/M transition of mitotic cell cycle
GO:0015631 tubulin binding
GO:0019901 protein kinase binding
GO:0022008 neurogenesis
GO:0030054 cell junction
GO:0031023 microtubule organizing center organization
GO:0031116 positive regulation of microtubule polymerization
GO:0035371 microtubule plus-end
GO:0043015 gamma-tubulin binding
GO:0045664 regulation of neuron differentiation
GO:0045665 negative regulation of neuron differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046600 negative regulation of centriole replication
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular exosome
GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint
GO:0097431 mitotic spindle pole
GO:0097711 ciliary basal body-plasma membrane docking

Subcellular Location

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Subcellular Location
Cytoplasm
Golgi apparatus

Domains

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DomainNameCategoryType
IPR012943 Centrosomin, N-terminal motif 1DomainDomain

Diseases

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Disease IDSourceNameDescription
604804 OMIMMicrocephaly 3, primary, autosomal recessive (MCPH3)A disease defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Affected individuals are mentally retarded. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits due to degenerative brain disorder. The disease is caused by variants affecting the gene represented in this entry.

Interactions

46 interactions

InteractorPartnerSourcesPublicationsLink
CK5P2_HUMANABCA2_HUMANBioGRID, HPRD, IntAct12421765 details
CK5P2_HUMANSTK36_HUMANBioGRID, HPRD, IntAct12421765 details
CK5P2_HUMANTBCD4_HUMANHPRD, IntAct12421765 unassigned5 details
CK5P2_HUMANEF1G_HUMANBioGRID, HPRD, IntAct16169070 details
CK5P2_HUMANDPYL1_HUMANBioGRID, HPRD, IntAct16169070 details
CK5P2_HUMANRBM48_HUMANBioGRID, HPRD, IntAct16169070 details
CK5P2_HUMANERG28_HUMANBioGRID, HPRD, IntAct16169070 details
CK5P2_HUMANHAP1_HUMANBioGRID, IntAct16169070 details
CK5P2_HUMANKAT5_HUMANBioGRID, HPRD, IntAct16169070 details
CK5P2_HUMANLC7L2_HUMANBioGRID, HPRD, IntAct16169070 details
CK5P2_HUMANMAGH1_HUMANBioGRID, HPRD, IntAct16169070 details
CK5P2_HUMANPTN_HUMANBioGRID, HPRD, IntAct16169070 details
CK5P2_HUMANSENP2_HUMANBioGRID, HPRD, IntAct16169070 details
CK5P2_HUMANZPR1_HUMANBioGRID, HPRD, IntAct16169070 details
CK5P2_HUMANSTAR9_HUMANBioGRID, HPRD, IntAct16169070 details
CK5P2_HUMANNFL_HUMANHPRD, IntAct16169070 details
CK5P2_HUMANTRI37_HUMANBioGRID, IntAct21988832 details
CK5P2_HUMANCLIP4_HUMANBioGRID, IntAct23414517 details
CK5P2_HUMANMARE1_HUMANBioGRID, IntAct21988832 26496610 29162697 34079125 details
CK5P2_HUMANCD5R1_HUMANBioGRID, HPRD10721722 10915792 11882646 details
CK5P2_HUMANCDK5_HUMANBioGRID10915792 details
CK5P2_HUMANTSNAX_HUMANBioGRID21988832 details
CK5P2_HUMANPHS_HUMANBioGRID21988832 details
CK5P2_HUMANFBX25_HUMANBioGRID21988832 details
CK5P2_HUMANREPS2_HUMANHPRD15184881 details
CK5P2_HUMANKAPCA_HUMANBioGRID, IntAct23455922 29162697 details
CK5P2_HUMANPCNT_HUMANBioGRID, DIP, IntAct20466722 26297806 26496610 34079125 details
CK5P2_HUMANMYOME_HUMANBioGRID, IntAct28514442 29162697 details
CK5P2_HUMANCEP68_HUMANBioGRID, DIP25503564 details
CK5P2_HUMANLRRK1_HUMANDIP26192437 details
CK5P2_HUMANTBG1_HUMANBioGRID, DIP21135143 26192437 details
CK5P2_HUMANSPAG5_HUMANDIP26297806 details
CK5P2_HUMANCEP72_HUMANDIP26297806 details
CK5P2_HUMANCE152_HUMANBioGRID, DIP24613305 26297806 34079125 details
CK5P2_HUMANAKAP9_HUMANBioGRID, DIP20466722 26297806 29162697 34079125 details
CK5P2_HUMANEXOC1_HUMANIntAct31413325 details
CK5P2_HUMANGCP6_HUMANBioGRID21135143 details
CK5P2_HUMANGCP5_HUMANBioGRID21135143 details
CK5P2_HUMANGCP2_HUMANBioGRID21135143 34079125 details
CK5P2_HUMANGCP3_HUMANBioGRID21135143 details
CK5P2_HUMANNDK7_HUMANBioGRID21135143 details
CK5P2_HUMANMZT2A_HUMANBioGRID21135143 details
CK5P2_HUMANMZT2B_HUMANBioGRID21135143 details
CK5P2_HUMANKAP2_HUMANBioGRID29162697 34079125 details
CK5P2_HUMANLG3BP_HUMANBioGRID29162697 details
CK5P2_HUMANTBK1_HUMANBioGRID29395067 details