Entity Details

Primary name I12R2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ99665
EntryNameI12R2_HUMAN
FullNameInterleukin-12 receptor subunit beta-2
TaxID9606
Evidenceevidence at protein level
Length862
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesIL12RB2

GO terms

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GOName
GO:0004896 cytokine receptor activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007166 cell surface receptor signaling pathway
GO:0008284 positive regulation of cell population proliferation
GO:0009897 external side of plasma membrane
GO:0019221 cytokine-mediated signaling pathway
GO:0019955 cytokine binding
GO:0032729 positive regulation of interferon-gamma production
GO:0035722 interleukin-12-mediated signaling pathway
GO:0043235 receptor complex
GO:0070757 interleukin-35-mediated signaling pathway

Subcellular Location

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Subcellular Location
Membrane

Domains

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DomainNameCategoryType
IPR003529 Long hematopoietin receptor, Gp130 family 2, conserved siteSiteConserved site
IPR003961 Fibronectin type IIIDomainDomain
IPR010457 Immunoglobulin C2-set-like, ligand-bindingDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily

Diseases

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