Entity Details

Primary name TIMP4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ99727
EntryNameTIMP4_HUMAN
FullNameMetalloproteinase inhibitor 4
TaxID9606
Evidenceevidence at transcript level
Length224
SequenceStatuscomplete
DateCreated1998-12-15
DateModified2021-06-02

Ontological Relatives

GenesTIMP4

GO terms

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GOName
GO:0002020 protease binding
GO:0004857 enzyme inhibitor activity
GO:0005615 extracellular space
GO:0007219 Notch signaling pathway
GO:0007417 central nervous system development
GO:0008191 metalloendopeptidase inhibitor activity
GO:0009725 response to hormone
GO:0010033 response to organic substance
GO:0010951 negative regulation of endopeptidase activity
GO:0030017 sarcomere
GO:0031012 extracellular matrix
GO:0032496 response to lipopolysaccharide
GO:0034097 response to cytokine
GO:0042493 response to drug
GO:0042698 ovulation cycle
GO:0043434 response to peptide hormone
GO:0046872 metal ion binding
GO:0051045 negative regulation of membrane protein ectodomain proteolysis

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR001134 Netrin domainDomainDomain
IPR001820 Protease inhibitor I35 (TIMP)FamilyFamily
IPR008993 Tissue inhibitor of metalloproteinases-like, OB-foldFamilyHomologous superfamily
IPR015614 Metalloproteinase inhibitor 4FamilyFamily
IPR027465 Proteinase inhibitor I35b (TIMP), C-terminalFamilyHomologous superfamily
IPR030490 Tissue inhibitor of metalloproteinase, conserved siteSiteConserved site

Diseases

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Interactions

3 interactions