Entity Details

Primary name SMO_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ99835
EntryNameSMO_HUMAN
FullNameSmoothened homolog
TaxID9606
Evidenceevidence at protein level
Length787
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesSMO

GO terms

Show/Hide Table
GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001570 vasculogenesis
GO:0001649 osteoblast differentiation
GO:0001701 in utero embryonic development
GO:0001708 cell fate specification
GO:0001755 neural crest cell migration
GO:0001947 heart looping
GO:0002052 positive regulation of neuroblast proliferation
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0003140 determination of left/right asymmetry in lateral mesoderm
GO:0003323 type B pancreatic cell development
GO:0004930 G protein-coupled receptor activity
GO:0005113 patched binding
GO:0005886 plasma membrane
GO:0005929 cilium
GO:0007224 smoothened signaling pathway
GO:0007228 positive regulation of hh target transcription factor activity
GO:0007371 ventral midline determination
GO:0007417 central nervous system development
GO:0007494 midgut development
GO:0009952 anterior/posterior pattern specification
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0016021 integral component of membrane
GO:0021542 dentate gyrus development
GO:0021696 cerebellar cortex morphogenesis
GO:0021794 thalamus development
GO:0021904 dorsal/ventral neural tube patterning
GO:0021910 smoothened signaling pathway involved in ventral spinal cord patterning
GO:0021938 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
GO:0021953 central nervous system neuron differentiation
GO:0021987 cerebral cortex development
GO:0030335 positive regulation of cell migration
GO:0030425 dendrite
GO:0030666 endocytic vesicle membrane
GO:0030857 negative regulation of epithelial cell differentiation
GO:0031069 hair follicle morphogenesis
GO:0034504 protein localization to nucleus
GO:0035264 multicellular organism growth
GO:0040018 positive regulation of multicellular organism growth
GO:0042307 positive regulation of protein import into nucleus
GO:0042475 odontogenesis of dentin-containing tooth
GO:0043066 negative regulation of apoptotic process
GO:0043231 intracellular membrane-bounded organelle
GO:0043392 negative regulation of DNA binding
GO:0045880 positive regulation of smoothened signaling pathway
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046622 positive regulation of organ growth
GO:0048143 astrocyte activation
GO:0048741 skeletal muscle fiber development
GO:0048745 smooth muscle tissue development
GO:0048853 forebrain morphogenesis
GO:0048873 homeostasis of number of cells within a tissue
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050821 protein stabilization
GO:0051451 myoblast migration
GO:0051799 negative regulation of hair follicle development
GO:0060170 ciliary membrane
GO:0060242 contact inhibition
GO:0060413 atrial septum morphogenesis
GO:0060644 mammary gland epithelial cell differentiation
GO:0060684 epithelial-mesenchymal cell signaling
GO:0061053 somite development
GO:0061113 pancreas morphogenesis
GO:0070062 extracellular exosome
GO:0070986 left/right axis specification
GO:0071397 cellular response to cholesterol
GO:0071679 commissural neuron axon guidance
GO:0072285 mesenchymal to epithelial transition involved in metanephric renal vesicle formation
GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis
GO:0097542 ciliary tip
GO:0097731 9+0 non-motile cilium
GO:2000036 regulation of stem cell population maintenance
GO:2000826 regulation of heart morphogenesis

Subcellular Location

Show/Hide Table
Subcellular Location
Cell projection
Membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR000539 Frizzled/Smoothened, transmembrane domainDomainDomain
IPR015526 Frizzled/secreted frizzled-related proteinFamilyFamily
IPR017981 GPCR, family 2-likeDomainDomain
IPR020067 Frizzled domainDomainDomain
IPR026544 SmoothenedFamilyFamily
IPR035683 Smoothened, transmembrane domainDomainDomain
IPR036790 Frizzled cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR041771 Smoothened, cysteine-rich domainDomainDomain

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB01047 FluocinonideDrugbanksmall molecule
DB06786 HalcinonideDrugbanksmall molecule
DB08828 VismodegibDrugbanksmall molecule
DB09143 SonidegibDrugbanksmall molecule
DB11978 GlasdegibDrugbanksmall molecule

Interactions

36 interactions

InteractorPartnerSourcesPublicationsLink
SMO_HUMANILK_HUMANMINT23877428 details
SMO_HUMANARRB2_HUMANMINT23877428 details
SMO_HUMANARRB1_HUMANMINT23877428 details
SMO_HUMANARV1_HUMANBioGRID, MINT28298427 details
SMO_HUMANNFIP1_HUMANBioGRID, MINT28298427 details
SMO_HUMANJPH3_HUMANBioGRID, MINT28298427 details
SMO_HUMANNIPA1_HUMANBioGRID, MINT28298427 details
SMO_HUMANS41A3_HUMANBioGRID, MINT28298427 details
SMO_HUMANSSPN_HUMANBioGRID, MINT28298427 details
SMO_HUMANRPN2_HUMANBioGRID, MINT28298427 details
SMO_HUMANOBRG_HUMANBioGRID, MINT28298427 details
SMO_HUMANPLPP7_HUMANBioGRID, MINT28298427 details
SMO_HUMANCR032_HUMANBioGRID, MINT28298427 details
SMO_HUMANEMC10_HUMANBioGRID, MINT28298427 details
SMO_HUMANTIDC1_HUMANBioGRID, MINT28298427 details
SMO_HUMANS1PR5_HUMANBioGRID, MINT28298427 details
SMO_HUMANFKBP8_HUMANBioGRID, MINT28298427 details
SMO_HUMANWLS_HUMANBioGRID, MINT28298427 details
SMO_HUMANGBRL2_HUMANBioGRID, MINT28298427 details
SMO_HUMANGABR1_HUMANBioGRID, MINT28298427 details
SMO_HUMANCD003_HUMANBioGRID, MINT28298427 details
SMO_HUMANHMOX1_HUMANBioGRID, MINT28298427 details
SMO_HUMANHMOX2_HUMANBioGRID, MINT28298427 details
SMO_HUMANHMGN4_HUMANBioGRID, MINT28298427 details
SMO_HUMANITBP1_HUMANBioGRID, MINT28298427 details
SMO_HUMANNGEF_HUMANBioGRID, MINT28298427 details
SMO_HUMANTSN7_HUMANBioGRID, MINT28298427 details
SMO_HUMANTMCC2_HUMANBioGRID, MINT28298427 details
SMO_HUMANNEDD4_HUMANBioGRID23106887 details
SMO_HUMANPTC1_HUMANbhf-ucl, BioGRID, HPRD11278759 9811851 details
SMO_HUMANPTC2_HUMANBioGRID, HPRD9811851 details
SMO_HUMANGNAI1_HUMANBioGRID31168089 details
SMO_HUMANGBB1_HUMANBioGRID31168089 details
SMO_HUMANGBG1_HUMANBioGRID31168089 details
SMO_HUMANHERC4_HUMANBioGRID31010679 details
SMO_HUMANARBK1_HUMANBioGRID31253779 details