Entity Details

Primary name HDAC8_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9BY41
EntryNameHDAC8_HUMAN
FullNameHistone deacetylase 8
TaxID9606
Evidenceevidence at protein level
Length377
SequenceStatuscomplete
DateCreated2003-04-11
DateModified2021-06-02

Ontological Relatives

GenesHDAC8

GO terms

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GOName
GO:0000118 histone deacetylase complex
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000228 nuclear chromosome
GO:0004407 histone deacetylase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0006325 chromatin organization
GO:0006333 chromatin assembly or disassembly
GO:0007062 sister chromatid cohesion
GO:0008134 transcription factor binding
GO:0030544 Hsp70 protein binding
GO:0031397 negative regulation of protein ubiquitination
GO:0031647 regulation of protein stability
GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0032204 regulation of telomere maintenance
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046872 metal ion binding
GO:0051879 Hsp90 protein binding
GO:0070932 histone H3 deacetylation
GO:0070933 histone H4 deacetylation
GO:0071922 regulation of cohesin loading

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000286 Histone deacetylase familyFamilyFamily
IPR003084 Histone deacetylaseFamilyFamily
IPR023696 Ureohydrolase domain superfamilyFamilyHomologous superfamily
IPR023801 Histone deacetylase domainDomainDomain
IPR037138 Histone deacetylase domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01592 IronDrugbanksmall molecule
DB01593 ZincDrugbanksmall molecule
DB02546 VorinostatDrugbanksmall molecule
DB02565 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamideDrugbanksmall molecule
DB02917 N-Hydroxy-4-(Methyl{[5-(2-Pyridinyl)-2-Thienyl]Sulfonyl}Amino)BenzamideDrugbanksmall molecule
DB04297 Trichostatin ADrugbanksmall molecule
DB05015 BelinostatDrugbanksmall molecule
DB06603 PanobinostatDrugbanksmall molecule
DB07350 (2E)-N-hydroxy-3-[1-methyl-4-(phenylacetyl)-1H-pyrrol-2-yl]prop-2-enamideDrugbanksmall molecule
DB07586 5-(4-METHYL-BENZOYLAMINO)-BIPHENYL-3,4'-DICARBOXYLIC ACID 3-DIMETHYLAMIDE-4'-HYDROXYAMIDEDrugbanksmall molecule
DB08168 Coumarin 120Drugbanksmall molecule
DB14487 Zinc acetateDrugbanksmall molecule
DB14488 Ferrous gluconateDrugbanksmall molecule
DB14489 Ferrous succinateDrugbanksmall molecule
DB14490 Ferrous ascorbateDrugbanksmall molecule
DB14491 Ferrous fumarateDrugbanksmall molecule
DB14501 Ferrous glycine sulfateDrugbanksmall molecule
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule