Entity Details

Primary name ABCA2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9BZC7
EntryNameABCA2_HUMAN
FullNameATP-binding cassette sub-family A member 2
TaxID9606
Evidenceevidence at protein level
Length2435
SequenceStatuscomplete
DateCreated2001-07-11
DateModified2021-06-02

Ontological Relatives

GenesABCA2

GO terms

Show/Hide Table
GOName
GO:0000166 nucleotide binding
GO:0001573 ganglioside metabolic process
GO:0005319 lipid transporter activity
GO:0005524 ATP binding
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005768 endosome
GO:0005815 microtubule organizing center
GO:0005886 plasma membrane
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006629 lipid metabolic process
GO:0006684 sphingomyelin metabolic process
GO:0006687 glycosphingolipid metabolic process
GO:0006869 lipid transport
GO:0007626 locomotory behavior
GO:0010008 endosome membrane
GO:0010872 regulation of cholesterol esterification
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016887 ATP hydrolysis activity
GO:0031410 cytoplasmic vesicle
GO:0032289 central nervous system myelin formation
GO:0032383 regulation of intracellular cholesterol transport
GO:0032384 negative regulation of intracellular cholesterol transport
GO:0032805 positive regulation of low-density lipoprotein particle receptor catabolic process
GO:0042493 response to drug
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0042632 cholesterol homeostasis
GO:0042986 positive regulation of amyloid precursor protein biosynthetic process
GO:0043190 ATP-binding cassette (ABC) transporter complex
GO:0043231 intracellular membrane-bounded organelle
GO:0046512 sphingosine biosynthetic process
GO:0048545 response to steroid hormone
GO:0055085 transmembrane transport
GO:0060049 regulation of protein glycosylation
GO:0061135 endopeptidase regulator activity
GO:0070723 response to cholesterol
GO:0071072 negative regulation of phospholipid biosynthetic process
GO:0090155 negative regulation of sphingolipid biosynthetic process
GO:0090156 cellular sphingolipid homeostasis
GO:0090370 negative regulation of cholesterol efflux
GO:0099038 ceramide floppase activity
GO:0099040 ceramide translocation
GO:0150104 transport across blood-brain barrier
GO:0150110 negative regulation of cholesterol esterification
GO:1901873 regulation of post-translational protein modification
GO:1902004 positive regulation of amyloid-beta formation
GO:1902993 positive regulation of amyloid precursor protein catabolic process
GO:1904375 regulation of protein localization to cell periphery
GO:1905598 negative regulation of low-density lipoprotein receptor activity
GO:1905601 negative regulation of receptor-mediated endocytosis involved in cholesterol transport
GO:2000008 regulation of protein localization to cell surface

Subcellular Location

Show/Hide Table
Subcellular Location
Endosome membrane
Lysosome membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR003439 ABC transporter-like, ATP-binding domainDomainDomain
IPR003593 AAA+ ATPase domainDomainDomain
IPR017871 ABC transporter-like, conserved siteSiteConserved site
IPR026082 ABC transporter AFamilyFamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR030366 ATP-binding cassette subfamily A member 2FamilyFamily

Diseases

Show/Hide Table

Interactions

4 interactions

InteractorPartnerSourcesPublicationsLink
ABCA2_HUMANCK5P2_HUMANBioGRID, HPRD, IntAct12421765 details
ABCA2_HUMANCAC1A_HUMANBioGRID, IntAct21078624 details
ABCA2_HUMANDRD2_HUMANBioGRID, MINT28298427 details
ABCA2_HUMAN5HT6R_HUMANBioGRID, MINT28298427 details