Entity Details

Primary name CYLD_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NQC7
EntryNameCYLD_HUMAN
FullNameUbiquitin carboxyl-terminal hydrolase CYLD
TaxID9606
Evidenceevidence at protein level
Length956
SequenceStatuscomplete
DateCreated2004-08-16
DateModified2021-06-02

Ontological Relatives

GenesCYLD

GO terms

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GOName
GO:0004843 thiol-dependent deubiquitinase
GO:0005813 centrosome
GO:0005819 spindle
GO:0005829 cytosol
GO:0005874 microtubule
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007049 cell cycle
GO:0007346 regulation of mitotic cell cycle
GO:0008270 zinc ion binding
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
GO:0016055 Wnt signaling pathway
GO:0016579 protein deubiquitination
GO:0019901 protein kinase binding
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032480 negative regulation of type I interferon production
GO:0036064 ciliary basal body
GO:0045087 innate immune response
GO:0046329 negative regulation of JNK cascade
GO:0048471 perinuclear region of cytoplasm
GO:0050727 regulation of inflammatory response
GO:0060544 regulation of necroptotic process
GO:0061578 Lys63-specific deubiquitinase activity
GO:0070064 proline-rich region binding
GO:0070266 necroptotic process
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway
GO:0070507 regulation of microtubule cytoskeleton organization
GO:0070536 protein K63-linked deubiquitination
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0097542 ciliary tip
GO:1901223 negative regulation of NIK/NF-kappaB signaling
GO:1902017 regulation of cilium assembly
GO:1903753 negative regulation of p38MAPK cascade
GO:1990108 protein linear deubiquitination
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
GO:2001242 regulation of intrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm

Domains

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DomainNameCategoryType
IPR000938 CAP Gly-rich domainDomainDomain
IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolaseDomainDomain
IPR018200 Ubiquitin specific protease, conserved siteSiteConserved site
IPR028889 Ubiquitin specific protease domainDomainDomain
IPR036859 CAP Gly-rich domain superfamilyFamilyHomologous superfamily
IPR038765 Papain-like cysteine peptidase superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
601606 OMIMMultiple familial trichoepithelioma 1 (MFT1)Autosomal dominant dermatosis characterized by the presence of many skin tumors predominantly on the face. Since histologic examination shows dermal aggregates of basaloid cells with connection to or differentiation toward hair follicles, this disorder has been thought to represent a benign hamartoma of the pilosebaceous apparatus. Trichoepitheliomas can degenerate into basal cell carcinoma. The disease is caused by variants affecting the gene represented in this entry.
605041 OMIMBrooke-Spiegler syndrome (BRSS)An autosomal dominant disorder characterized by the appearance of multiple skin appendage tumors such as cylindroma, trichoepithelioma, and spiradenoma. These tumors are typically located in the head and neck region, appear in early adulthood, and gradually increase in size and number throughout life. The disease is caused by variants affecting the gene represented in this entry.
132700 OMIMCylindromatosis, familial (FCYL)A disorder characterized by multiple skin tumors that develop from skin appendages, such as hair follicles and sweat glands. Affected individuals typically develop large numbers of tumors called cylindromas that arise predominantly in hairy parts of the body with approximately 90% on the head and neck. In severely affected individuals, cylindromas may combine into a confluent mass which may ulcerate or become infected (turban tumor syndrome). Individuals with familial cylindromatosis occasionally develop other types of tumors including spiradenomas that begin in sweat glands, and trichoepitheliomas arising from hair follicles. The disease is caused by variants affecting the gene represented in this entry.

Interactions

75 interactions

InteractorPartnerSourcesPublicationsLink
CYLD_HUMANIKKE_HUMANBioGRID, MINT18636086 23453969 29755980 details
CYLD_HUMANTBK1_HUMANBioGRID, MINT18636086 25923723 29755980 details
CYLD_HUMANUBC_HUMANBioGRID, MINT17851586 19373254 20622874 29576527 30388174 32185393 33390248 details
CYLD_HUMANSPAT2_HUMANBioGRID, IntAct, MINT19615732 24981860 27307491 27458237 27545878 27591049 31067453 31762063 details
CYLD_HUMANTBA1A_HUMANBioGRID, MINT18222923 19893491 details
CYLD_HUMANHDAC6_HUMANBioGRID, MINT19893491 20593489 details
CYLD_HUMANNEMO_HUMANBioGRID, HPRD, IntAct12917689 12917690 12917691 15341735 16627981 21988832 22990857 26802121 30561431 31366726 details
CYLD_HUMANITCH_HUMANBioGRID, InnateDB22057290 details
CYLD_HUMANM3K7_HUMANBioGRID18332137 27591049 29291351 32410369 details
CYLD_HUMANTRAIP_HUMANBioGRID, HPRD14676304 details
CYLD_HUMANTRAF2_HUMANBioGRID, HPRD12917691 23405219 27591049 28900035 details
CYLD_HUMANTRAF6_HUMANBioGRID, HPRD12917691 16230348 20622874 26056944 29933112 details
CYLD_HUMANOPTN_HUMANBioGRID21408173 25923723 details
CYLD_HUMANUBE2S_HUMANBioGRID20622874 details
CYLD_HUMANAURKB_HUMANBioGRID20593489 details
CYLD_HUMANPTPA_HUMANBioGRID20593489 details
CYLD_HUMANAKT1_HUMANBioGRID23300340 details
CYLD_HUMANMARE1_HUMANBioGRID24552808 details
CYLD_HUMANMIB2_HUMANBioGRID25565632 31366726 details
CYLD_HUMANP53_HUMANBioGRID27561390 details
CYLD_HUMANCYLD_HUMANBioGRID27591049 28187457 28881612 31067453 31762063 details
CYLD_HUMANDLG4_HUMANBioGRID28973854 details
CYLD_HUMANTRI47_HUMANBioGRID29291351 details
CYLD_HUMANPLK4_HUMANBioGRID31762063 details
CYLD_HUMANCENPV_HUMANBioGRID31260673 details
CYLD_HUMANDDX58_HUMANBioGRID, HPRD, MINT18636086 details
CYLD_HUMANMAVS_HUMANBioGRID, MINT18636086 30410068 details
CYLD_HUMANCE192_HUMANBioGRID, IntAct19615732 22895009 24613305 details
CYLD_HUMANVIP1_HUMANBioGRID18636086 details
CYLD_HUMANRIPK1_HUMANBioGRID17981138 21408173 22848449 28900035 details
CYLD_HUMANPLK1_HUMANBioGRID17495026 details
CYLD_HUMANPMS2_HUMANBioGRID17148452 details
CYLD_HUMANPMS1_HUMANBioGRID17148452 details
CYLD_HUMANTRPA1_HUMANBioGRID16500080 details
CYLD_HUMANBCL3_HUMANBioGRID19893491 details
CYLD_HUMANDVL1_HUMANBioGRID20227366 details
CYLD_HUMANDVL3_HUMANBioGRID20227366 details
CYLD_HUMANSQSTM_HUMANBioGRID19201866 32453962 details
CYLD_HUMANCLIP3_HUMANBioGRID22297296 26017671 details
CYLD_HUMANARHGC_HUMANBioGRID23405219 details
CYLD_HUMANCD209_HUMANBioGRID24867235 details
CYLD_HUMANCE350_HUMANBioGRID25134987 31067453 details
CYLD_HUMANRNF31_HUMANBioGRID26670046 27307491 27458237 27545878 27591049 28189684 details
CYLD_HUMANSHRPN_HUMANBioGRID26670046 27591049 31067453 details
CYLD_HUMANTNFA_HUMANBioGRID26670046 27307491 27458237 27545878 31898971 details
CYLD_HUMANNOD2_HUMANBioGRID26670046 27545878 details
CYLD_HUMANKCC2A_HUMANBioGRID24614225 details
CYLD_HUMANMYD88_HUMANBioGRID26719415 details
CYLD_HUMANTNR1A_HUMANBioGRID24098568 27552911 27591049 30420664 details
CYLD_HUMANSDC4_HUMANBioGRID27279133 details
CYLD_HUMANPLAT4_HUMANBioGRID27279133 details
CYLD_HUMANAPRIO_HUMANBioGRID28900035 details
CYLD_HUMANPRIO_HUMANBioGRID28900035 details
CYLD_HUMANDDB2_HUMANBioGRID28035050 details
CYLD_HUMANCBLB_HUMANBioGRID28572092 details
CYLD_HUMANEGFR_HUMANBioGRID28572092 details
CYLD_HUMANNOX4_HUMANBioGRID28751569 details
CYLD_HUMANTNR9_HUMANBioGRID29296520 details
CYLD_HUMANCTNB1_HUMANBioGRID30323974 31067453 details
CYLD_HUMANSTING_HUMANBioGRID30388174 details
CYLD_HUMANSMAD7_HUMANBioGRID30315770 details
CYLD_HUMANCP131_HUMANBioGRID31067453 details
CYLD_HUMANMIB1_HUMANBioGRID31067453 31462741 details
CYLD_HUMANPCM1_HUMANBioGRID31067453 details
CYLD_HUMANTBG1_HUMANBioGRID31067453 details
CYLD_HUMANTNR6B_HUMANBioGRID29395067 31762063 details
CYLD_HUMANTNR6A_HUMANBioGRID29395067 details
CYLD_HUMANTNR6C_HUMANBioGRID29395067 details
CYLD_HUMANMARF1_HUMANBioGRID29395067 details
CYLD_HUMANULK1_HUMANBioGRID32453962 details
CYLD_HUMANPK3C3_HUMANBioGRID32453962 details
CYLD_HUMANATG5_HUMANBioGRID32453962 details
CYLD_HUMANBECN1_HUMANBioGRID32453962 details
CYLD_HUMANMALT1_HUMANBioGRID33329596 details
CYLD_HUMANTRAF7_HUMANHPRD16230348 details