Entity Details

Primary name PLPL3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NST1
EntryNamePLPL3_HUMAN
FullName1-acylglycerol-3-phosphate O-acyltransferase PNPLA3
TaxID9606
Evidenceevidence at protein level
Length481
SequenceStatuscomplete
DateCreated2003-07-03
DateModified2021-06-02

Ontological Relatives

GenesPNPLA3

GO terms

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GOName
GO:0001676 long-chain fatty acid metabolic process
GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity
GO:0004623 phospholipase A2 activity
GO:0004806 triglyceride lipase activity
GO:0005737 cytoplasm
GO:0005789 endoplasmic reticulum membrane
GO:0005811 lipid droplet
GO:0006650 glycerophospholipid metabolic process
GO:0006654 phosphatidic acid biosynthetic process
GO:0009744 response to sucrose
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0019432 triglyceride biosynthetic process
GO:0019433 triglyceride catabolic process
GO:0032869 cellular response to insulin stimulus
GO:0034389 lipid droplet organization
GO:0035727 lysophosphatidic acid binding
GO:0036042 long-chain fatty acyl-CoA binding
GO:0036153 triglyceride acyl-chain remodeling
GO:0036155 acylglycerol acyl-chain remodeling
GO:0042171 lysophosphatidic acid acyltransferase activity
GO:0050872 white fat cell differentiation
GO:0051264 mono-olein transacylation activity
GO:0051265 diolein transacylation activity
GO:0055088 lipid homeostasis
GO:1905243 cellular response to 3,3',5-triiodo-L-thyronine

Subcellular Location

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Subcellular Location
Lipid droplet
Membrane

Domains

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DomainNameCategoryType
IPR002641 Patatin-like phospholipase domainDomainDomain
IPR016035 Acyl transferase/acyl hydrolase/lysophospholipaseFamilyHomologous superfamily
IPR033562 Patatin-like phospholipase domain-containing proteinFamilyFamily
IPR039185 1-acylglycerol-3-phosphate O-acyltransferase PNPLA3FamilyFamily

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
PLPL3_HUMANAKT2_HUMANBioGRID, IntAct21988832 details
PLPL3_HUMANSNX27_HUMANBioGRID, IntAct21988832 details