Entity Details

Primary name E2AK3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NZJ5
EntryNameE2AK3_HUMAN
FullNameEukaryotic translation initiation factor 2-alpha kinase 3
TaxID9606
Evidenceevidence at protein level
Length1116
SequenceStatuscomplete
DateCreated2001-09-26
DateModified2021-06-02

Ontological Relatives

GenesEIF2AK3

GO terms

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GOName
GO:0001501 skeletal system development
GO:0001503 ossification
GO:0001525 angiogenesis
GO:0002063 chondrocyte development
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0006468 protein phosphorylation
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006983 ER overload response
GO:0007029 endoplasmic reticulum organization
GO:0010575 positive regulation of vascular endothelial growth factor production
GO:0010628 positive regulation of gene expression
GO:0010998 regulation of translational initiation by eIF2 alpha phosphorylation
GO:0016020 membrane
GO:0017148 negative regulation of translation
GO:0018105 peptidyl-serine phosphorylation
GO:0019722 calcium-mediated signaling
GO:0019899 enzyme binding
GO:0019903 protein phosphatase binding
GO:0030176 integral component of endoplasmic reticulum membrane
GO:0030282 bone mineralization
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0031018 endocrine pancreas development
GO:0031642 negative regulation of myelination
GO:0032057 negative regulation of translational initiation in response to stress
GO:0034198 cellular response to amino acid starvation
GO:0034976 response to endoplasmic reticulum stress
GO:0036492 eiF2alpha phosphorylation in response to endoplasmic reticulum stress
GO:0036499 PERK-mediated unfolded protein response
GO:0042149 cellular response to glucose starvation
GO:0042802 identical protein binding
GO:0045943 positive regulation of transcription by RNA polymerase I
GO:0046777 protein autophosphorylation
GO:0048009 insulin-like growth factor receptor signaling pathway
GO:0048471 perinuclear region of cytoplasm
GO:0051879 Hsp90 protein binding
GO:0060734 regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
GO:0070417 cellular response to cold
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1900182 positive regulation of protein localization to nucleus
GO:1902235 regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1990737 response to manganese-induced endoplasmic reticulum stress

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011047 Quinoprotein alcohol dehydrogenase-like superfamilyFamilyHomologous superfamily
IPR015943 WD40/YVTN repeat-like-containing domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site

Diseases

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Disease IDSourceNameDescription
226980 OMIMWolcott-Rallison syndrome (WRS)A rare autosomal recessive disorder, characterized by permanent neonatal or early infancy insulin-dependent diabetes and, at a later age, epiphyseal dysplasia, osteoporosis, growth retardation and other multisystem manifestations, such as hepatic and renal dysfunctions, mental retardation and cardiovascular abnormalities. The disease is caused by variants affecting the gene represented in this entry.