Entity Details

Primary name MTRR_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UBK8
EntryNameMTRR_HUMAN
FullNameMethionine synthase reductase
TaxID9606
Evidenceevidence at protein level
Length698
SequenceStatuscomplete
DateCreated2002-03-27
DateModified2021-06-02

Ontological Relatives

GenesMTRR

GO terms

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GOName
GO:0000096 sulfur amino acid metabolic process
GO:0003958 NADPH-hemoprotein reductase activity
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006306 DNA methylation
GO:0009086 methionine biosynthetic process
GO:0009235 cobalamin metabolic process
GO:0010181 FMN binding
GO:0016491 oxidoreductase activity
GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
GO:0016723 oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor
GO:0030586 [methionine synthase] reductase activity
GO:0032259 methylation
GO:0033353 S-adenosylmethionine cycle
GO:0043418 homocysteine catabolic process
GO:0045111 intermediate filament cytoskeleton
GO:0046655 folic acid metabolic process
GO:0050660 flavin adenine dinucleotide binding
GO:0050667 homocysteine metabolic process
GO:0070402 NADPH binding
GO:0071949 FAD binding
GO:1904042 negative regulation of cystathionine beta-synthase activity

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR001094 Flavodoxin-likeDomainDomain
IPR001433 Oxidoreductase FAD/NAD(P)-bindingDomainDomain
IPR001709 Flavoprotein pyridine nucleotide cytochrome reductaseDomainDomain
IPR003097 Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-bindingDomainDomain
IPR008254 Flavodoxin/nitric oxide synthaseDomainDomain
IPR017927 FAD-binding domain, ferredoxin reductase-typeDomainDomain
IPR017938 Riboflavin synthase-like beta-barrelFamilyHomologous superfamily
IPR023173 NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamilyFamilyHomologous superfamily
IPR029039 Flavoprotein-like superfamilyFamilyHomologous superfamily
IPR039261 Ferredoxin-NADP reductase (FNR), nucleotide-binding domainFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00115 CyanocobalaminDrugbanksmall molecule
DB00134 MethionineDrugbanksmall molecule

Interactions

3 interactions