Entity Details

Primary name XRCC3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO43542
EntryNameXRCC3_HUMAN
FullNameDNA repair protein XRCC3
TaxID9606
Evidenceevidence at protein level
Length346
SequenceStatuscomplete
DateCreated2002-04-03
DateModified2021-06-02

Ontological Relatives

GenesXRCC3

GO terms

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GOName
GO:0000722 telomere maintenance via recombination
GO:0000724 double-strand break repair via homologous recombination
GO:0000781 chromosome, telomeric region
GO:0003677 DNA binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005657 replication fork
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0006974 cellular response to DNA damage stimulus
GO:0008094 ATPase, acting on DNA
GO:0010033 response to organic substance
GO:0010824 regulation of centrosome duplication
GO:0033065 Rad51C-XRCC3 complex
GO:0036297 interstrand cross-link repair
GO:0045003 double-strand break repair via synthesis-dependent strand annealing
GO:0048471 perinuclear region of cytoplasm
GO:0071140 resolution of mitotic recombination intermediates
GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint
GO:0090656 t-circle formation
GO:0090657 telomeric loop disassembly
GO:0090737 telomere maintenance via telomere trimming

Subcellular Location

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Subcellular Location
Cytoplasm
Mitochondrion
Nucleus

Domains

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DomainNameCategoryType
IPR013632 DNA recombination and repair protein Rad51-like, C-terminalDomainDomain
IPR016467 DNA recombination and repair protein, RecA-likeFamilyFamily
IPR020588 DNA recombination and repair protein RecA-like, ATP-binding domainDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR033925 Rad51/DMC1/RadADomainDomain

Diseases

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Interactions

24 interactions

InteractorPartnerSourcesPublicationsLink
XRCC3_HUMANSWAP1_HUMANBioGRID, UniProt21965664 details
XRCC3_HUMANZSWM7_HUMANBioGRID, UniProt21965664 details
XRCC3_HUMANBCAS3_HUMANBioGRID, MINT25640309 details
XRCC3_HUMANGROA_HUMANBioGRID, MINT25640309 details
XRCC3_HUMANLRAT2_HUMANBioGRID, MINT25640309 details
XRCC3_HUMANGREB1_HUMANBioGRID, MINT25640309 details
XRCC3_HUMANITIH5_HUMANBioGRID, MINT25640309 details
XRCC3_HUMANMRC2_HUMANBioGRID, MINT25640309 details
XRCC3_HUMANOSGI1_HUMANBioGRID, MINT25640309 details
XRCC3_HUMANHOP2_HUMANBioGRID, MINT25640309 details
XRCC3_HUMANBAP1_HUMANBioGRID, MINT25640309 details
XRCC3_HUMANBRE1A_HUMANBioGRID, MINT25640309 details
XRCC3_HUMANSG3A1_HUMANBioGRID, MINT25640309 details
XRCC3_HUMANSPB5_HUMANBioGRID, MINT25640309 details
XRCC3_HUMANSNAI1_HUMANBioGRID, MINT25640309 details
XRCC3_HUMANTFF1_HUMANBioGRID, MINT25640309 details
XRCC3_HUMANTRI25_HUMANBioGRID, MINT25640309 29117863 details
XRCC3_HUMANRA51C_HUMANBioGRID, DIP, HPRD, IntAct, UniProt11331762 11459987 11744692 11751635 11842112 11842113 12853621 14704354 15037616 15115758 15126333 17114795 24005329 24141787 26496610 28864920 9469824 details
XRCC3_HUMANPALB2_HUMANBioGRID, UniProt24141787 details
XRCC3_HUMANRAD51_HUMANBioGRID, IntAct, UniProt11842113 15065660 17302439 28864920 9660962 details
XRCC3_HUMANZNHI3_HUMANBioGRID, IntAct20211142 details
XRCC3_HUMANFANCG_HUMANBioGRID, HPRD16621732 18212739 20450923 details
XRCC3_HUMANBRCA2_HUMANBioGRID, IntAct, UniProt16621732 18212739 20450923 24141787 26496610 details
XRCC3_HUMANRA51D_HUMANHPRD11744692 details