Entity Details

Primary name ING1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UK53
EntryNameING1_HUMAN
FullNameInhibitor of growth protein 1
TaxID9606
Evidenceevidence at protein level
Length422
SequenceStatuscomplete
DateCreated2004-01-16
DateModified2021-06-02

Ontological Relatives

GenesING1

GO terms

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GOName
GO:0005634 nucleus
GO:0007049 cell cycle
GO:0008285 negative regulation of cell population proliferation
GO:0010941 regulation of cell death
GO:0030308 negative regulation of cell growth
GO:0035064 methylated histone binding
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046872 metal ion binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001965 Zinc finger, PHD-typeDomainDomain
IPR011011 Zinc finger, FYVE/PHD-typeFamilyHomologous superfamily
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR019786 Zinc finger, PHD-type, conserved siteSiteConserved site
IPR019787 Zinc finger, PHD-fingerDomainDomain
IPR024610 Inhibitor of growth protein, N-terminal histone-bindingDomainDomain
IPR028643 Inhibitor of growth protein 1FamilyFamily
IPR028651 ING familyFamilyFamily

Diseases

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Disease IDSourceNameDescription
275355 OMIMSquamous cell carcinoma of the head and neck (HNSCC)A non-melanoma skin cancer affecting the head and neck. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes. The disease is caused by variants affecting the gene represented in this entry.

Interactions

48 interactions

InteractorPartnerSourcesPublicationsLink
ING1_HUMANUBC_HUMANBioGRID, MINT18388957 21731648 details
ING1_HUMANNQO1_HUMANBioGRID, HPRD, MINT18388957 details
ING1_HUMAN1433Z_HUMANBioGRID, HPRD, MINT16581770 details
ING1_HUMAN1433F_HUMANBioGRID, HPRD, MINT16581770 details
ING1_HUMAN1433B_HUMANBioGRID, HPRD, MINT16581770 details
ING1_HUMAN1433G_HUMANBioGRID, HPRD, MINT16581770 details
ING1_HUMAN1433E_HUMANBioGRID, HPRD, MINT16581770 details
ING1_HUMAN1433T_HUMANBioGRID, HPRD, MINT16581770 details
ING1_HUMAN1433S_HUMANBioGRID, HPRD, MINT16581770 details
ING1_HUMANSAP30_HUMANBioGRID, HPRD, IntAct11118440 11784859 15451426 26496610 details
ING1_HUMANEXOC4_HUMANBioGRID, IntAct32296183 details
ING1_HUMANDMAP1_HUMANBioGRID, HPRD14665632 details
ING1_HUMANESR1_HUMANBioGRID14630091 details
ING1_HUMANH32_HUMANBioGRID18533182 details
ING1_HUMANCSN2_HUMANBioGRID17929852 details
ING1_HUMANCTRL_HUMANMINT18388957 details
ING1_HUMANSMUF1_HUMANBioGRID, MINT20621832 details
ING1_HUMANHDAC1_HUMANBioGRID, HPRD, IntAct11118440 11784859 12015309 15451426 18193082 23752268 26496610 details
ING1_HUMANRBBP7_HUMANBioGRID, HPRD, IntAct11784859 15451426 26186194 28514442 details
ING1_HUMANHDAC2_HUMANBioGRID, HPRD, MINT11118440 11784859 15451426 26949739 details
ING1_HUMANTRRAP_HUMANBioGRID12015309 details
ING1_HUMANKAT2B_HUMANBioGRID, HPRD12015309 details
ING1_HUMANCBP_HUMANBioGRID12015309 details
ING1_HUMANEP300_HUMANBioGRID, HPRD12015309 details
ING1_HUMANSIN3A_HUMANBioGRID, HPRD11118440 11784859 15451426 details
ING1_HUMANARI1A_HUMANBioGRID11784859 details
ING1_HUMANSMCA4_HUMANBioGRID11784859 details
ING1_HUMANSMRC2_HUMANBioGRID11784859 details
ING1_HUMANSMRC1_HUMANBioGRID11784859 details
ING1_HUMANRBBP4_HUMANBioGRID, HPRD11118440 11784859 15451426 details
ING1_HUMANSNF5_HUMANBioGRID11784859 details
ING1_HUMANSMRD1_HUMANBioGRID11784859 details
ING1_HUMANACL6A_HUMANBioGRID11784859 details
ING1_HUMANPCNA_HUMANBioGRID, HPRD11682605 12015309 16288740 details
ING1_HUMANP53_HUMANBioGRID, HPRD12208736 19085961 9440695 details
ING1_HUMANCDN2A_HUMANBioGRID19085961 details
ING1_HUMANARF_HUMANBioGRID19085961 details
ING1_HUMANLMNA_HUMANBioGRID18836436 details
ING1_HUMANIMA1_HUMANBioGRID18655775 details
ING1_HUMANIMB1_HUMANBioGRID18655775 details
ING1_HUMANSIR2_HUMANBioGRID14522900 details
ING1_HUMANSIR1_HUMANBioGRID18193082 details
ING1_HUMANRET1_HUMANBioGRID, HPRD11118440 15451426 details
ING1_HUMANBRM1L_HUMANBioGRID, HPRD15451426 details
ING1_HUMANBRMS1_HUMANBioGRID15451426 details
ING1_HUMANPAF15_HUMANBioGRID16288740 details
ING1_HUMANUBP7_HUMANBioGRID21731648 details
ING1_HUMANHIF1A_HUMANBioGRID25611387 details