Entity Details

Primary name MA1B1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UKM7
EntryNameMA1B1_HUMAN
FullNameEndoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase
TaxID9606
Evidenceevidence at protein level
Length699
SequenceStatuscomplete
DateCreated2001-11-16
DateModified2021-06-02

Ontological Relatives

GenesMAN1B1

GO terms

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GOName
GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
GO:0005509 calcium ion binding
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0006486 protein glycosylation
GO:0006491 N-glycan processing
GO:0009311 oligosaccharide metabolic process
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0019082 viral protein processing
GO:0030433 ubiquitin-dependent ERAD pathway
GO:0031410 cytoplasmic vesicle
GO:0036508 protein alpha-1,2-demannosylation
GO:0036509 trimming of terminal mannose on B branch
GO:0036510 trimming of terminal mannose on C branch
GO:0036511 trimming of first mannose on A branch
GO:0036512 trimming of second mannose on A branch
GO:0044322 endoplasmic reticulum quality control compartment
GO:1903561 extracellular vesicle
GO:1904380 endoplasmic reticulum mannose trimming
GO:1904382 mannose trimming involved in glycoprotein ERAD pathway

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane

Domains

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DomainNameCategoryType
IPR001382 Glycoside hydrolase family 47FamilyFamily
IPR012341 Six-hairpin glycosidase-like superfamilyFamilyHomologous superfamily
IPR036026 Seven-hairpin glycosidasesFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01955 1,4-ButanediolDrugbanksmall molecule
DB02422 Methyl-2-S-(Alpha-D-Mannopyranosyl)-2-Thio-Alpha-D-MannopyranosideDrugbanksmall molecule
DB02742 KifunensineDrugbanksmall molecule
DB03206 DuvoglustatDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
MA1B1_HUMANDYN2_HUMANBioGRID, MINT21900206 details