Entity Details

Primary name AGO2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UKV8
EntryNameAGO2_HUMAN
FullNameProtein argonaute-2
TaxID9606
Evidenceevidence at protein level
Length859
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesAGO2

GO terms

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GOName
GO:0000340 RNA 7-methylguanosine cap binding
GO:0000932 P-body
GO:0000993 RNA polymerase II complex binding
GO:0001046 core promoter sequence-specific DNA binding
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0003727 single-stranded RNA binding
GO:0003743 translation initiation factor activity
GO:0004521 endoribonuclease activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005844 polysome
GO:0005845 mRNA cap binding complex
GO:0006412 translation
GO:0007223 Wnt signaling pathway, calcium modulating pathway
GO:0008022 protein C-terminus binding
GO:0009791 post-embryonic development
GO:0010501 RNA secondary structure unwinding
GO:0010586 miRNA metabolic process
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0016020 membrane
GO:0016442 RISC complex
GO:0030422 production of siRNA involved in RNA interference
GO:0030425 dendrite
GO:0030522 intracellular receptor signaling pathway
GO:0031047 gene silencing by RNA
GO:0031054 pre-miRNA processing
GO:0035087 siRNA loading onto RISC involved in RNA interference
GO:0035194 post-transcriptional gene silencing by RNA
GO:0035196 production of miRNAs involved in gene silencing by miRNA
GO:0035197 siRNA binding
GO:0035198 miRNA binding
GO:0035278 miRNA mediated inhibition of translation
GO:0035279 mRNA cleavage involved in gene silencing by miRNA
GO:0035280 miRNA loading onto RISC involved in gene silencing by miRNA
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0042985 negative regulation of amyloid precursor protein biosynthetic process
GO:0045766 positive regulation of angiogenesis
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0045947 negative regulation of translational initiation
GO:0045975 positive regulation of translation, ncRNA-mediated
GO:0046872 metal ion binding
GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:0060964 regulation of gene silencing by miRNA
GO:0070062 extracellular exosome
GO:0070551 endoribonuclease activity, cleaving siRNA-paired mRNA
GO:0070578 RISC-loading complex
GO:0090624 endoribonuclease activity, cleaving miRNA-paired mRNA
GO:0090625 mRNA cleavage involved in gene silencing by siRNA
GO:0098808 mRNA cap binding
GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:1901165 positive regulation of trophoblast cell migration
GO:1905618 positive regulation of miRNA mediated inhibition of translation
GO:1990904 ribonucleoprotein complex

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR003100 PAZ domainDomainDomain
IPR003165 Piwi domainDomainDomain
IPR012337 Ribonuclease H-like superfamilyFamilyHomologous superfamily
IPR014811 Argonaute, linker 1 domainDomainDomain
IPR028602 Protein argonaute-2FamilyFamily
IPR032472 Argonaute linker 2 domainDomainDomain
IPR032473 Protein argonaute, Mid domainDomainDomain
IPR032474 Protein argonaute, N-terminalDomainDomain
IPR036085 PAZ domain superfamilyFamilyHomologous superfamily
IPR036397 Ribonuclease H superfamilyFamilyHomologous superfamily

Diseases

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Interactions

117 interactions

InteractorPartnerSourcesPublicationsLink
AGO2_HUMANDICER_HUMANbhf-ucl, BioGRID, DIP, HPRD, IntAct, MINT, UniProt12526743 14749716 16357216 17932509 18178619 19716330 19820710 19955415 21858095 22484317 23143396 23622242 23636329 23661684 23741051 24778252 25446899 26496610 29395067 details
AGO2_HUMANIPO8_HUMANBioGRID, IntAct, MINT17932509 19167051 details
AGO2_HUMANTNR6B_HUMANBioGRID, DIP, IntAct, MINT, UniProt17891150 17932509 19383768 19470757 19716330 19838187 24043833 24778252 29395067 32414810 details
AGO2_HUMANGEMI4_HUMANBioGRID, MINT11914277 14970384 17932509 23143396 details
AGO2_HUMANUBC_HUMANBioGRID, MINT16196087 17932509 28190767 details
AGO2_HUMANPFKAP_HUMANBioGRID, IntAct21988832 details
AGO2_HUMANTNR6A_HUMANBioGRID, DIP, IntAct, MINT, UniProt17938239 19324964 19383768 19470757 19716330 21840310 22484317 23090477 24778252 28683311 28813667 28877994 29395067 details
AGO2_HUMANDHX58_HUMANBioGRID, IntAct21903422 details
AGO2_HUMANTBKB1_HUMANBioGRID, IntAct21903422 details
AGO2_HUMANTBK1_HUMANBioGRID, IntAct21903422 details
AGO2_HUMANZMAT3_HUMANMINT23085987 details
AGO2_HUMANTNR6C_HUMANBioGRID, DIP, UniProt19383768 19470757 19838187 21981923 24778252 29395067 details
AGO2_HUMANAGO1_HUMANBioGRID, DIP, HPRD15908945 16756390 24086155 24778252 29395067 details
AGO2_HUMANDDX6_HUMANBioGRID, DIP, UniProt16756390 23535175 28683311 29395067 details
AGO2_HUMANEGFR_HUMANDIP23636329 details
AGO2_HUMANLIMD1_HUMANUniProt28683311 details
AGO2_HUMANTRI63_HUMANBioGRID, IntAct31391242 details
AGO2_HUMANTRI55_HUMANBioGRID, IntAct31391242 details
AGO2_HUMANFGFR3_HUMANIntAct32814053 details
AGO2_HUMANSPRE1_HUMANIntAct32814053 details
AGO2_HUMANDDX20_HUMANBioGRID, HPRD11914277 14970384 details
AGO2_HUMANMAPK2_HUMANBioGRID18476811 details
AGO2_HUMANRAD51_HUMANBioGRID26822153 28973861 details
AGO2_HUMANNSD2_HUMANBioGRID26822153 details
AGO2_HUMANKAT5_HUMANBioGRID26822153 details
AGO2_HUMANHS90A_HUMANBioGRID, UniProt14749716 16357216 19716330 25681748 details
AGO2_HUMANTRBP2_HUMANBioGRID, DIP, HPRD, IntAct, MINT, UniProt16357216 16424907 17932509 18178619 19716330 19820710 23622242 23636329 24778252 26496610 29395067 details
AGO2_HUMANPRKRA_HUMANbhf-ucl, HPRD, MINT16424907 23661684 details
AGO2_HUMANELAV1_HUMANBioGRID, MINT17932509 19322201 23901138 31103853 details
AGO2_HUMANPABP1_HUMANBioGRID, IntAct, MINT, UniProt17932509 19716330 28877994 29395067 details
AGO2_HUMANDHX9_HUMANBioGRID, DIP, MINT17531811 17932509 19955415 26902284 details
AGO2_HUMANGNL3_HUMANMINT17932509 24550003 details
AGO2_HUMANRBM4_HUMANBioGRID, MINT17932509 21562054 details
AGO2_HUMANIF2B1_HUMANBioGRID, MINT17932509 29395067 details
AGO2_HUMANRACK1_HUMANMINT21525958 details
AGO2_HUMANCNOT7_HUMANBioGRID, UniProt19716330 21981923 29395067 details
AGO2_HUMANLRRK2_HUMANBioGRID, DIP, IntAct17400507 20671708 details
AGO2_HUMANCNOT1_HUMANBioGRID, UniProt21981923 28813667 29395067 details
AGO2_HUMANCNOT8_HUMANBioGRID, UniProt21981923 details
AGO2_HUMANCNOT2_HUMANBioGRID, UniProt21981923 29395067 details
AGO2_HUMANCNOT6_HUMANUniProt21981923 details
AGO2_HUMANCNO6L_HUMANBioGRID, UniProt21981923 29395067 details
AGO2_HUMAN4EBP1_HUMANBioGRID, DIP20671708 details
AGO2_HUMANTEBP_HUMANIntAct23741051 details
AGO2_HUMANFKBP4_HUMANBioGRID, IntAct23741051 29395067 details
AGO2_HUMANLYRIC_HUMANIntAct24981741 details
AGO2_HUMANRC3H1_HUMANBioGRID, IntAct25697406 29395067 details
AGO2_HUMANTERT_HUMANMINT24550003 details
AGO2_HUMANPKHA7_HUMANIntAct28877994 details
AGO2_HUMANCTND1_HUMANIntAct28877994 details
AGO2_HUMANRB_HUMANDIP22366686 details
AGO2_HUMANPRIO_HUMANDIP22484317 details
AGO2_HUMANWTIP_HUMANUniProt28683311 details
AGO2_HUMANGGYF2_HUMANBioGRID20696395 details
AGO2_HUMANHD_HUMANBioGRID18669659 details
AGO2_HUMANTNFA_HUMANBioGRID21562054 27545878 details
AGO2_HUMANMEX3D_HUMANBioGRID17267406 details
AGO2_HUMANLIN41_HUMANBioGRID24602972 31732746 details
AGO2_HUMANCBWD2_HUMANBioGRID24778252 details
AGO2_HUMANIGBP1_HUMANBioGRID24778252 details
AGO2_HUMANIQEC1_HUMANBioGRID24778252 details
AGO2_HUMANKLH29_HUMANBioGRID24778252 details
AGO2_HUMANMSI1H_HUMANBioGRID24778252 details
AGO2_HUMANPASK_HUMANBioGRID24778252 details
AGO2_HUMANOBI1_HUMANBioGRID24778252 29395067 details
AGO2_HUMANTRM1_HUMANBioGRID24778252 details
AGO2_HUMANDCAF7_HUMANBioGRID24778252 details
AGO2_HUMANYTHD1_HUMANBioGRID24778252 29395067 details
AGO2_HUMANATOH1_HUMANBioGRID27542412 details
AGO2_HUMANTYY1_HUMANBioGRID29120412 31957155 details
AGO2_HUMANUBR5_HUMANBioGRID28559278 details
AGO2_HUMANCTR9_HUMANBioGRID26902284 details
AGO2_HUMANPAF1_HUMANBioGRID26902284 details
AGO2_HUMANPCBP2_HUMANBioGRID26902284 details
AGO2_HUMANRPB1_HUMANBioGRID26902284 details
AGO2_HUMANESR2_HUMANBioGRID29509190 details
AGO2_HUMANKBTB8_HUMANBioGRID25681748 29395067 details
AGO2_HUMANZCCHV_HUMANBioGRID25681748 29395067 details
AGO2_HUMANRBBP5_HUMANBioGRID28813667 details
AGO2_HUMANZ3H7A_HUMANBioGRID29395067 30995489 details
AGO2_HUMANCTCF_HUMANBioGRID28973861 details
AGO2_HUMANDCP1A_HUMANBioGRID, HPRD15937477 29395067 details
AGO2_HUMANF120A_HUMANBioGRID29395067 details
AGO2_HUMANMOV10_HUMANBioGRID29395067 details
AGO2_HUMANOTUD4_HUMANBioGRID29395067 details
AGO2_HUMANPATL1_HUMANBioGRID29395067 details
AGO2_HUMANPRC2B_HUMANBioGRID29395067 details
AGO2_HUMANSMG7_HUMANBioGRID29395067 details
AGO2_HUMANTDRD3_HUMANBioGRID29395067 details
AGO2_HUMANUBP2L_HUMANBioGRID29395067 details
AGO2_HUMANYTHD2_HUMANBioGRID29395067 details
AGO2_HUMANFXR2_HUMANBioGRID29395067 details
AGO2_HUMANHELZ_HUMANBioGRID29395067 details
AGO2_HUMANLS14A_HUMANBioGRID29395067 details
AGO2_HUMANMARF1_HUMANBioGRID29395067 details
AGO2_HUMANMEX3B_HUMANBioGRID29395067 details
AGO2_HUMANMKRN2_HUMANBioGRID29395067 details
AGO2_HUMANPAIP2_HUMANBioGRID29395067 details
AGO2_HUMANPRC2A_HUMANBioGRID29395067 details
AGO2_HUMANPUM1_HUMANBioGRID29395067 details
AGO2_HUMANR3HD2_HUMANBioGRID29395067 details
AGO2_HUMANRBMS1_HUMANBioGRID29395067 details
AGO2_HUMANRN214_HUMANBioGRID29395067 details
AGO2_HUMANSMAG2_HUMANBioGRID29395067 details
AGO2_HUMANSMAP2_HUMANBioGRID29395067 details
AGO2_HUMANUNK_HUMANBioGRID29395067 details
AGO2_HUMANXRN1_HUMANBioGRID29395067 details
AGO2_HUMANYTHD3_HUMANBioGRID29395067 details
AGO2_HUMANTTP_HUMANBioGRID29395067 details
AGO2_HUMANLS14B_HUMANBioGRID29395067 details
AGO2_HUMANTUT4_HUMANBioGRID29395067 details
AGO2_HUMANZCHC3_HUMANBioGRID29395067 details
AGO2_HUMANEST1A_HUMANBioGRID29395067 details
AGO2_HUMANGLE1_HUMANBioGRID29395067 details
AGO2_HUMANLAR4B_HUMANBioGRID29395067 details
AGO2_HUMANRBM47_HUMANBioGRID29395067 details
AGO2_HUMANDCP2_HUMANHPRD15937477 details