Entity Details

Primary name CBLC_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9ULV8
EntryNameCBLC_HUMAN
FullNameE3 ubiquitin-protein ligase CBL-C
TaxID9606
Evidenceevidence at protein level
Length474
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesCBLC

GO terms

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GOName
GO:0001784 phosphotyrosine residue binding
GO:0005154 epidermal growth factor receptor binding
GO:0005509 calcium ion binding
GO:0005886 plasma membrane
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007175 negative regulation of epidermal growth factor-activated receptor activity
GO:0008270 zinc ion binding
GO:0016567 protein ubiquitination
GO:0017124 SH3 domain binding
GO:0030971 receptor tyrosine kinase binding
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0043407 negative regulation of MAP kinase activity
GO:0045121 membrane raft
GO:0061630 ubiquitin protein ligase activity

Subcellular Location

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Domains

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DomainNameCategoryType
IPR001841 Zinc finger, RING-typeDomainDomain
IPR003153 Adaptor protein Cbl, N-terminal helicalDomainDomain
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR014741 Adaptor protein Cbl, EF hand-likeDomainDomain
IPR014742 Adaptor protein Cbl, SH2-like domainDomainDomain
IPR017907 Zinc finger, RING-type, conserved siteSiteConserved site
IPR024159 Adaptor protein Cbl, PTB domainDomainDomain
IPR024162 Adaptor protein CblFamilyFamily
IPR036537 Adaptor protein Cbl, N-terminal domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

61 interactions

InteractorPartnerSourcesPublicationsLink
CBLC_HUMANITCH_HUMANBioGRID, HPRD, MINT12226085 details
CBLC_HUMANUBE2H_HUMANBioGRID, IntAct19549727 details
CBLC_HUMANUBC9_HUMANBioGRID, IntAct19549727 details
CBLC_HUMANUB2L3_HUMANBioGRID, IntAct19549727 details
CBLC_HUMANUB2L6_HUMANBioGRID, IntAct19549727 details
CBLC_HUMANUB2R2_HUMANBioGRID, IntAct19549727 details
CBLC_HUMANABI1_HUMANMINT20598684 details
CBLC_HUMANOXA1L_HUMANBioGRID, IntAct21988832 details
CBLC_HUMANBIRC2_HUMANBioGRID, IntAct22493164 details
CBLC_HUMANTRAF4_HUMANBioGRID, IntAct22493164 details
CBLC_HUMANCHFR_HUMANBioGRID, IntAct22493164 details
CBLC_HUMANTRI46_HUMANBioGRID, IntAct22493164 details
CBLC_HUMANNACAD_HUMANBioGRID, MINT21900206 details
CBLC_HUMANSH3G3_HUMANBioGRID, MINT21900206 details
CBLC_HUMANSHC1_HUMANBioGRID, MINT21900206 details
CBLC_HUMANCRK_HUMANBioGRID, HPRD, IntAct10362357 10571044 25814554 details
CBLC_HUMANBAP1_HUMANBioGRID, IntAct27107012 details
CBLC_HUMANYES_HUMANBioGRID, IntAct32296183 details
CBLC_HUMANUBE2K_HUMANBioGRID, IntAct19549727 32814053 details
CBLC_HUMANATX1_HUMANIntAct32814053 details
CBLC_HUMANTADBP_HUMANIntAct32814053 details
CBLC_HUMANEGFR_HUMANBioGRID, HPRD10362357 10571044 22888118 29945960 31959764 details
CBLC_HUMANFYN_HUMANBioGRID10571044 details
CBLC_HUMANLYN_HUMANBioGRID, HPRD10362357 details
CBLC_HUMANKCRM_HUMANBioGRID20525694 details
CBLC_HUMANSRC_HUMANBioGRID, HPRD14661060 20525694 22888118 9988270 details
CBLC_HUMANZAP70_HUMANBioGRID22888118 details
CBLC_HUMANUB2D2_HUMANBioGRID14661060 20525694 details
CBLC_HUMANUBP2_HUMANBioGRID23105109 details
CBLC_HUMANUBP21_HUMANBioGRID23105109 details
CBLC_HUMANOTU6A_HUMANBioGRID23105109 details
CBLC_HUMANTGFI1_HUMANBioGRID23145173 24831009 details
CBLC_HUMANTRIP6_HUMANBioGRID23145173 details
CBLC_HUMANPDLI7_HUMANBioGRID24466333 details
CBLC_HUMANUB2D3_HUMANBioGRID14661060 details
CBLC_HUMANUB2D1_HUMANBioGRID14661060 details
CBLC_HUMANUBC_HUMANBioGRID14661060 details
CBLC_HUMANCCND2_HUMANBioGRID28205554 details
CBLC_HUMANEPHA2_HUMANBioGRID28205554 details
CBLC_HUMANMERL_HUMANBioGRID28205554 details
CBLC_HUMANSTK11_HUMANBioGRID28205554 details
CBLC_HUMANAKT1_HUMANBioGRID28205554 details
CBLC_HUMANCDK6_HUMANBioGRID28205554 details
CBLC_HUMANCDN2B_HUMANBioGRID28205554 details
CBLC_HUMANERBB2_HUMANBioGRID28205554 details
CBLC_HUMANFGFR4_HUMANBioGRID28205554 details
CBLC_HUMANLATS2_HUMANBioGRID28205554 details
CBLC_HUMANMP2K3_HUMANBioGRID28205554 details
CBLC_HUMANMDM4_HUMANBioGRID28205554 details
CBLC_HUMANMYC_HUMANBioGRID28205554 details
CBLC_HUMANRAF1_HUMANBioGRID28205554 details
CBLC_HUMANTERT_HUMANBioGRID28205554 details
CBLC_HUMANP53_HUMANBioGRID28205554 details
CBLC_HUMANGLIS2_HUMANBioGRID28205554 details
CBLC_HUMANNFIC_HUMANBioGRID28205554 details
CBLC_HUMANNSD3_HUMANBioGRID28205554 details
CBLC_HUMANRET_HUMANBioGRID18753381 24466333 details
CBLC_HUMANCD2AP_HUMANBioGRID18753381 details
CBLC_HUMANMET_HUMANBioGRID22888118 details
CBLC_HUMANGRB2_HUMANHPRD10086340 details
CBLC_HUMANSPY2_HUMANHPRD12234920 details