Entity Details

Primary name NOTC3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UM47
EntryNameNOTC3_HUMAN
FullNameNeurogenic locus notch homolog protein 3
TaxID9606
Evidenceevidence at protein level
Length2321
SequenceStatuscomplete
DateCreated2002-03-27
DateModified2021-06-02

Ontological Relatives

GenesNOTCH3

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0005509 calcium ion binding
GO:0005576 extracellular region
GO:0005654 nucleoplasm
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0007219 Notch signaling pathway
GO:0007221 positive regulation of transcription of Notch receptor target
GO:0007411 axon guidance
GO:0009986 cell surface
GO:0015629 actin cytoskeleton
GO:0016021 integral component of membrane
GO:0038023 signaling receptor activity
GO:0042802 identical protein binding
GO:0043235 receptor complex
GO:0045296 cadherin binding
GO:0045746 negative regulation of Notch signaling pathway
GO:0050793 regulation of developmental process

Subcellular Location

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Subcellular Location
Cell membrane
Nucleus

Domains

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DomainNameCategoryType
IPR000152 EGF-type aspartate/asparagine hydroxylation sitePTMPTM
IPR000742 EGF-like domainDomainDomain
IPR000800 Notch domainDomainDomain
IPR001881 EGF-like calcium-binding domainDomainDomain
IPR002110 Ankyrin repeatRepeatRepeat
IPR008297 NotchFamilyFamily
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR010660 Notch, NOD domainDomainDomain
IPR011656 Notch, NODP domainDomainDomain
IPR013032 EGF-like, conserved siteSiteConserved site
IPR018097 EGF-like calcium-binding, conserved siteSiteConserved site
IPR020683 Ankyrin repeat-containing domainDomainDomain
IPR022331 Neurogenic locus Notch 3FamilyFamily
IPR024600 Domain of unknown function DUF3454, notchDomainDomain
IPR035993 Notch-like domain superfamilyFamilyHomologous superfamily
IPR036770 Ankyrin repeat-containing domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

62 interactions

InteractorPartnerSourcesPublicationsLink
NOTC3_HUMANABL1_HUMANIntAct17474147 details
NOTC3_HUMANNCK1_HUMANIntAct17474147 details
NOTC3_HUMANFBLN1_HUMANBioGRID, IntAct21988832 details
NOTC3_HUMANCSK2B_HUMANBioGRID, MINT21900206 details
NOTC3_HUMANANR28_HUMANBioGRID, IntAct23414517 details
NOTC3_HUMANJAG1_HUMANBioGRID, HPRD, MINT11006133 12482954 14714274 22487239 details
NOTC3_HUMANSUH_HUMANBioGRID, HPRD, IntAct, MINT11404076 25356737 25609649 26186194 28514442 details
NOTC3_HUMANPR20D_HUMANBioGRID, IntAct32296183 details
NOTC3_HUMANNOTC3_HUMANDIP26051713 details
NOTC3_HUMANSNW1_HUMANBioGRID, HPRD11404076 details
NOTC3_HUMANDLL1_HUMANBioGRID, HPRD11006133 12482954 details
NOTC3_HUMANJAG2_HUMANBioGRID, HPRD11006133 details
NOTC3_HUMANMAML1_HUMANBioGRID, HPRD11101851 details
NOTC3_HUMANEGFL7_HUMANBioGRID19503073 details
NOTC3_HUMANMPPD2_HUMANBioGRID25356737 details
NOTC3_HUMANGGT6_HUMANBioGRID25356737 details
NOTC3_HUMANMTG8R_HUMANBioGRID25356737 details
NOTC3_HUMANSPTC2_HUMANBioGRID25356737 details
NOTC3_HUMANRET_HUMANBioGRID25356737 details
NOTC3_HUMANMYC_HUMANBioGRID25356737 details
NOTC3_HUMANVINEX_HUMANBioGRID25356737 details
NOTC3_HUMANWWP2_HUMANBioGRID25356737 details
NOTC3_HUMANTNNT2_HUMANBioGRID25356737 details
NOTC3_HUMANXKR8_HUMANBioGRID25356737 details
NOTC3_HUMANSNX19_HUMANBioGRID25356737 details
NOTC3_HUMANCNTD1_HUMANBioGRID25356737 details
NOTC3_HUMANWDR25_HUMANBioGRID25356737 details
NOTC3_HUMANSG3A1_HUMANBioGRID25356737 details
NOTC3_HUMANCPNE6_HUMANBioGRID25356737 details
NOTC3_HUMANBAG2_HUMANBioGRID25356737 details
NOTC3_HUMANS39A1_HUMANBioGRID25356737 details
NOTC3_HUMANPPIA_HUMANBioGRID25356737 details
NOTC3_HUMANCH076_HUMANBioGRID25356737 details
NOTC3_HUMANC1QRF_HUMANBioGRID25356737 details
NOTC3_HUMANTM108_HUMANBioGRID25356737 details
NOTC3_HUMANCASL_HUMANBioGRID25356737 details
NOTC3_HUMANRMI2_HUMANBioGRID25356737 details
NOTC3_HUMANCRIP2_HUMANBioGRID25356737 details
NOTC3_HUMANBT3L4_HUMANBioGRID25356737 details
NOTC3_HUMANTCTP_HUMANBioGRID25356737 details
NOTC3_HUMANPR20E_HUMANBioGRID32296183 details
NOTC3_HUMANPR20C_HUMANBioGRID32296183 details
NOTC3_HUMANPR20B_HUMANBioGRID32296183 details
NOTC3_HUMANPR20A_HUMANBioGRID32296183 details
NOTC3_HUMANLTBP1_HUMANBioGRID25190493 details
NOTC3_HUMANKAT2B_HUMANHPRD11404076 details
NOTC3_HUMANLRP1_HUMANI2D20472562 details
NOTC3_HUMANHXA1_HUMANMINT21653829 details
NOTC3_HUMANMBD1_HUMANMINT21653829 details
NOTC3_HUMANNUFP2_HUMANMINT21653829 details
NOTC3_HUMANSHAN3_HUMANMINT21653829 details
NOTC3_HUMANGSK3B_HUMANBioGRID21502811 details
NOTC3_HUMANSTRAP_HUMANBioGRID21502811 details
NOTC3_HUMANPSA1_HUMANBioGRID17292860 details
NOTC3_HUMANCBL_HUMANBioGRID19966856 details
NOTC3_HUMANPTCRA_HUMANBioGRID19966856 details
NOTC3_HUMANCASR_HUMANBioGRID17573339 details
NOTC3_HUMANPSN1_HUMANHPRD11518718 details
NOTC3_HUMANPSN2_HUMANHPRD11518718 details
NOTC3_HUMANMAML2_HUMANHPRD12370315 details
NOTC3_HUMANMAML3_HUMANHPRD12370315 details
NOTC3_HUMANIKKA_HUMANHPRD17289033 details