Entity Details

Primary name CC14A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UNH5
EntryNameCC14A_HUMAN
FullNameDual specificity protein phosphatase CDC14A
TaxID9606
Evidenceevidence at protein level
Length594
SequenceStatuscomplete
DateCreated2004-11-23
DateModified2021-06-02

Ontological Relatives

GenesCDC14A

GO terms

Show/Hide Table
GOName
GO:0000226 microtubule cytoskeleton organization
GO:0000278 mitotic cell cycle
GO:0000922 spindle pole
GO:0004722 protein serine/threonine phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0007096 regulation of exit from mitosis
GO:0007605 sensory perception of sound
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0016604 nuclear body
GO:0032426 stereocilium tip
GO:0032467 positive regulation of cytokinesis
GO:0051301 cell division
GO:0060091 kinocilium
GO:0060271 cilium assembly
GO:0072686 mitotic spindle
GO:0106306 protein serine phosphatase activity
GO:0106307 protein threonine phosphatase activity
GO:1902636 kinociliary basal body

Subcellular Location

Show/Hide Table
Subcellular Location
Cell projection
Cytoplasm
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR000387 Tyrosine specific protein phosphatases domainDomainDomain
IPR003595 Protein-tyrosine phosphatase, catalyticDomainDomain
IPR016130 Protein-tyrosine phosphatase, active siteSiteActive site
IPR020422 Dual specificity protein phosphatase domainDomainDomain
IPR026068 Dual specificity protein phosphatase CDC14AFamilyFamily
IPR029021 Protein-tyrosine phosphatase-likeFamilyHomologous superfamily
IPR029260 Dual specificity/tyrosine protein phosphatase, N-terminalDomainDomain
IPR044506 Dual-specificity phosphatase CDC14, C-terminalDomainDomain

Diseases

Show/Hide Table
Disease IDSourceNameDescription
608653 OMIMDeafness, autosomal recessive, 32, with or without immotile sperm (DFNB32)A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNB32 is characterized by prelingual, progressive, moderate to profound sensorineural deafness. Some affected men are infertile. The disease is caused by variants affecting the gene represented in this entry.