Entity Details

Primary name CORIN_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9Y5Q5
EntryNameCORIN_HUMAN
FullNameAtrial natriuretic peptide-converting enzyme
TaxID9606
Evidenceevidence at protein level
Length1042
SequenceStatuscomplete
DateCreated2001-04-27
DateModified2021-06-02

Ontological Relatives

GenesCORIN

GO terms

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GOName
GO:0003050 regulation of systemic arterial blood pressure by atrial natriuretic peptide
GO:0004175 endopeptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007565 female pregnancy
GO:0008217 regulation of blood pressure
GO:0009986 cell surface
GO:0015629 actin cytoskeleton
GO:0016021 integral component of membrane
GO:0016486 peptide hormone processing
GO:0016604 nuclear body
GO:0035813 regulation of renal sodium excretion
GO:1903779 regulation of cardiac conduction

Subcellular Location

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Subcellular Location
Cell membrane
Secreted

Domains

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DomainNameCategoryType
IPR001254 Serine proteases, trypsin domainDomainDomain
IPR002172 Low-density lipoprotein (LDL) receptor class A repeatRepeatRepeat
IPR009003 Peptidase S1, PA clanFamilyHomologous superfamily
IPR017052 Atrial natriuretic peptide-converting enzyme corinFamilyFamily
IPR017448 SRCR-like domainDomainDomain
IPR020067 Frizzled domainDomainDomain
IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved siteSiteConserved site
IPR033116 Serine proteases, trypsin family, serine active siteSiteActive site
IPR036055 LDL receptor-like superfamilyFamilyHomologous superfamily
IPR036772 SRCR-like domain superfamilyFamilyHomologous superfamily
IPR036790 Frizzled cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR041762 Corin, cysteine-rich domain 1DomainDomain
IPR041763 Corin, cysteine-rich domain 2DomainDomain
IPR043504 Peptidase S1, PA clan, chymotrypsin-like foldFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
614595 OMIMPre-eclampsia/eclampsia 5 (PEE5)A hypertensive disorder of pregnancy characterized by new hypertension (blood pressure 140/90 or greater) presenting after 20 weeks' gestation with clinically relevant proteinuria. It impacts 2 individuals, the mother and her child, both of whom can be severely affected. Preeclampsia is one of the causes of maternal mortality and morbidity worldwide. The disease is caused by variants affecting the gene represented in this entry.

Interactions

4 interactions

InteractorPartnerSourcesPublicationsLink
CORIN_HUMANAQP6_HUMANBioGRID, IntAct32296183 details
CORIN_HUMANCLD5_HUMANBioGRID, IntAct32296183 details
CORIN_HUMANEMP1_HUMANBioGRID, IntAct32296183 details
CORIN_HUMANGPX8_HUMANBioGRID, IntAct32296183 details