Entity Details

Primary name BIG2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9Y6D5
EntryNameBIG2_HUMAN
FullNameBrefeldin A-inhibited guanine nucleotide-exchange protein 2
TaxID9606
Evidenceevidence at protein level
Length1785
SequenceStatuscomplete
DateCreated2001-02-21
DateModified2021-06-02

Ontological Relatives

GenesARFGEF2

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0001881 receptor recycling
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005879 axonemal microtubule
GO:0006887 exocytosis
GO:0006893 Golgi to plasma membrane transport
GO:0007032 endosome organization
GO:0010256 endomembrane system organization
GO:0015031 protein transport
GO:0016020 membrane
GO:0017022 myosin binding
GO:0031410 cytoplasmic vesicle
GO:0032012 regulation of ARF protein signal transduction
GO:0032279 asymmetric synapse
GO:0032280 symmetric synapse
GO:0032760 positive regulation of tumor necrosis factor production
GO:0034237 protein kinase A regulatory subunit binding
GO:0035556 intracellular signal transduction
GO:0043197 dendritic spine
GO:0043231 intracellular membrane-bounded organelle
GO:0048471 perinuclear region of cytoplasm
GO:0050811 GABA receptor binding
GO:0055037 recycling endosome

Subcellular Location

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Subcellular Location
Cell junction
Cell projection
Cytoplasm
Cytoplasmic vesicle
Endosome
Golgi apparatus
Membrane

Domains

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DomainNameCategoryType
IPR000904 Sec7 domainDomainDomain
IPR015403 Sec7, C-terminalDomainDomain
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR023394 Sec7, C-terminal domain superfamilyFamilyHomologous superfamily
IPR032629 Mon2, dimerisation and cyclophilin-binding domainDomainDomain
IPR032691 Guanine nucleotide exchange factor, N-terminalDomainDomain
IPR035999 Sec7 domain superfamilyFamilyHomologous superfamily

Diseases

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