Entity Details

Primary name BCL10_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO95999
EntryNameBCL10_HUMAN
FullNameB-cell lymphoma/leukemia 10
TaxID9606
Evidenceevidence at protein level
Length233
SequenceStatuscomplete
DateCreated2002-05-02
DateModified2021-06-02

Ontological Relatives

GenesBCL10

GO terms

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GOName
GO:0001772 immunological synapse
GO:0001783 B cell apoptotic process
GO:0001843 neural tube closure
GO:0002020 protease binding
GO:0002096 polkadots
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0002224 toll-like receptor signaling pathway
GO:0002250 adaptive immune response
GO:0002906 negative regulation of mature B cell apoptotic process
GO:0003713 transcription coactivator activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005829 cytosol
GO:0005881 cytoplasmic microtubule
GO:0006968 cellular defense response
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0008022 protein C-terminus binding
GO:0008134 transcription factor binding
GO:0008219 cell death
GO:0009620 response to fungus
GO:0016064 immunoglobulin mediated immune response
GO:0016567 protein ubiquitination
GO:0019899 enzyme binding
GO:0019900 kinase binding
GO:0019901 protein kinase binding
GO:0031398 positive regulation of protein ubiquitination
GO:0031625 ubiquitin protein ligase binding
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032094 response to food
GO:0032449 CBM complex
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032761 positive regulation of lymphotoxin A production
GO:0032765 positive regulation of mast cell cytokine production
GO:0032991 protein-containing complex
GO:0033674 positive regulation of kinase activity
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042327 positive regulation of phosphorylation
GO:0042802 identical protein binding
GO:0043065 positive regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043422 protein kinase B binding
GO:0043621 protein self-association
GO:0044877 protein-containing complex binding
GO:0045087 innate immune response
GO:0045121 membrane raft
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048471 perinuclear region of cytoplasm
GO:0050700 CARD domain binding
GO:0050852 T cell receptor signaling pathway
GO:0050856 regulation of T cell receptor signaling pathway
GO:0050870 positive regulation of T cell activation
GO:0051059 NF-kappaB binding
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0070231 T cell apoptotic process
GO:0071222 cellular response to lipopolysaccharide
GO:0071260 cellular response to mechanical stimulus
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm
Membrane raft

Domains

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DomainNameCategoryType
IPR001315 CARD domainDomainDomain
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR033238 B-cell lymphoma/leukemia 10/E10FamilyFamily
IPR042143 BCL10, CARD domainDomainDomain

Diseases

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Interactions

73 interactions

InteractorPartnerSourcesPublicationsLink
BCL10_HUMANCAR19_HUMANBioGRID, HPRD, MINT15637807 details
BCL10_HUMANAKT1_HUMANBioGRID, HPRD, IntAct, MINT16280327 24412244 24462114 details
BCL10_HUMANNEMO_HUMANBioGRID, DIP, HPRD, IntAct, MINT11113112 14695475 15184390 17363905 18287044 19897484 23690623 27070702 27777308 details
BCL10_HUMANCAR11_HUMANBioGRID, DIP, HPRD, IntAct, MINT11278692 11356195 16356855 17948050 18625728 18806265 19118383 19444310 19815501 21157432 21513986 22528498 23690623 24074955 25548215 27777308 30279415 details
BCL10_HUMANMALT1_HUMANBioGRID, DIP, HPRD, InnateDB, IntAct, MINT11090634 11262391 14695475 17189706 17948050 18806265 19118383 19279678 19444310 20551178 21157432 21513986 22267217 22528498 22658522 23690623 24130731 25548215 25569716 25748427 27070702 27071417 27113748 27777308 29953499 30279415 31961340 33329596 details
BCL10_HUMANCDK9_HUMANBioGRID, IntAct21988832 details
BCL10_HUMANI15RA_HUMANBioGRID, IntAct21988832 details
BCL10_HUMANSRSF1_HUMANBioGRID, IntAct21988832 details
BCL10_HUMANS20A1_HUMANBioGRID, IntAct21988832 details
BCL10_HUMANNHRF1_HUMANBioGRID, IntAct21988832 details
BCL10_HUMANTMG4_HUMANBioGRID, IntAct21988832 details
BCL10_HUMANUSBP1_HUMANBioGRID, IntAct21988832 details
BCL10_HUMANCARD9_HUMANBioGRID, HPRD, InnateDB, IntAct11053425 22267217 25416956 28765954 details
BCL10_HUMANAN32B_HUMANBioGRID, MINT24412244 details
BCL10_HUMANBAAT_HUMANBioGRID, MINT24412244 details
BCL10_HUMANF16P1_HUMANBioGRID, MINT24412244 details
BCL10_HUMANTRMO_HUMANBioGRID, MINT24412244 details
BCL10_HUMANCC14B_HUMANBioGRID, MINT24412244 details
BCL10_HUMANHEMGN_HUMANBioGRID, MINT24412244 details
BCL10_HUMANCC180_HUMANBioGRID, MINT24412244 details
BCL10_HUMANSIAS_HUMANBioGRID, MINT24412244 details
BCL10_HUMANRASA1_HUMANBioGRID, MINT24412244 details
BCL10_HUMANTGFB1_HUMANBioGRID, MINT24412244 details
BCL10_HUMANTRAF2_HUMANBioGRID, HPRD, IntAct10753917 11466612 25416956 25910212 32296183 details
BCL10_HUMANBCL10_HUMANBioGRID, HPIDb, HPRD, IntAct10187771 15125833 16775419 21896478 24074955 25416956 29382759 32296183 details
BCL10_HUMANCOG6_HUMANBioGRID, IntAct27107012 32296183 details
BCL10_HUMANIKKB_HUMANBioGRID, DIP11113112 14695475 17213322 19118383 details
BCL10_HUMANTR10A_HUMANBioGRID, HPRD10400625 details
BCL10_HUMANTNR1A_HUMANBioGRID10400625 details
BCL10_HUMANCAR10_HUMANBioGRID, HPRD11259443 11387339 15184390 details
BCL10_HUMANCAR14_HUMANBioGRID, HPRD11278692 27071417 details
BCL10_HUMANBIRC3_HUMANBioGRID10753917 11466612 16395405 16775419 details
BCL10_HUMANIRAK1_HUMANBioGRID16831874 details
BCL10_HUMANMIB2_HUMANBioGRID21896478 details
BCL10_HUMANIKKA_HUMANBioGRID, HPRD11113112 14695475 22547678 details
BCL10_HUMANATM_HUMANBioGRID24732096 details
BCL10_HUMANUB2V2_HUMANBioGRID, HPRD14695475 details
BCL10_HUMANUBE2N_HUMANBioGRID, HPRD14695475 details
BCL10_HUMANRN181_HUMANBioGRID26711259 details
BCL10_HUMANOTUL_HUMANBioGRID27777308 details
BCL10_HUMANBCL3_HUMANBioGRID, IntAct16280327 details
BCL10_HUMANKPCT_HUMANBioGRID, MINT17363905 20164171 details
BCL10_HUMANCSN5_HUMANMINT19444310 details
BCL10_HUMANKPCZ_HUMANIntAct25011391 details
BCL10_HUMANKC1A_HUMANBioGRID, DIP19118383 20551178 25088585 details
BCL10_HUMANTRADD_HUMANBioGRID, HPRD10400625 details
BCL10_HUMANNLRC4_HUMANBioGRID, HPRD11472070 details
BCL10_HUMANBIRC2_HUMANBioGRID10753917 16775419 details
BCL10_HUMANXIAP_HUMANBioGRID16775419 details
BCL10_HUMANIKBA_HUMANBioGRID20551178 details
BCL10_HUMANFYB1_HUMANBioGRID20164171 details
BCL10_HUMANKCC2G_HUMANBioGRID21513986 details
BCL10_HUMANTRAF6_HUMANBioGRID16920630 details
BCL10_HUMANDPP4_HUMANBioGRID17287217 details
BCL10_HUMANMK09_HUMANBioGRID17189706 details
BCL10_HUMANM3K7_HUMANBioGRID, HPRD16186825 17189706 details
BCL10_HUMANMP2K7_HUMANBioGRID17189706 details
BCL10_HUMANUSP9X_HUMANBioGRID23690623 details
BCL10_HUMANRNF8_HUMANBioGRID24732096 details
BCL10_HUMANRN168_HUMANBioGRID24732096 details
BCL10_HUMAN2AAA_HUMANBioGRID21157432 details
BCL10_HUMANPP2AA_HUMANBioGRID21157432 details
BCL10_HUMANSQSTM_HUMANBioGRID22658522 details
BCL10_HUMANMLP3A_HUMANBioGRID22658522 details
BCL10_HUMANATG5_HUMANBioGRID22658522 details
BCL10_HUMANRNF31_HUMANBioGRID27777308 details
BCL10_HUMANTMM43_HUMANBioGRID27991920 details
BCL10_HUMANHOIL1_HUMANBioGRID33329596 details
BCL10_HUMANCASP9_HUMANHPRD10187815 details
BCL10_HUMANTLR4_HUMANHPRD15213237 details
BCL10_HUMANRIPK2_HUMANHPRD14638696 details
BCL10_HUMANSOCS3_HUMANHPRD15213237 details
BCL10_HUMANPELI2_HUMANHPRD15213237 details