Entity Details

Primary name PH4H_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP00439
EntryNamePH4H_HUMAN
FullNamePhenylalanine-4-hydroxylase
TaxID9606
Evidenceevidence at protein level
Length452
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesPAH

GO terms

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GOName
GO:0004505 phenylalanine 4-monooxygenase activity
GO:0005506 iron ion binding
GO:0005829 cytosol
GO:0006558 L-phenylalanine metabolic process
GO:0006559 L-phenylalanine catabolic process
GO:0006571 tyrosine biosynthetic process
GO:0008652 cellular amino acid biosynthetic process
GO:0042136 neurotransmitter biosynthetic process
GO:0042423 catecholamine biosynthetic process

Subcellular Location

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Domains

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DomainNameCategoryType
IPR001273 Aromatic amino acid hydroxylaseFamilyFamily
IPR002912 ACT domainDomainDomain
IPR005961 Phenylalanine-4-hydroxylase, tetrameric formFamilyFamily
IPR018301 Aromatic amino acid hydroxylase, iron/copper binding siteSiteBinding site
IPR019773 Tyrosine 3-monooxygenase-likeFamilyFamily
IPR019774 Aromatic amino acid hydroxylase, C-terminalDomainDomain
IPR036329 Aromatic amino acid monoxygenase, C-terminal domain superfamilyFamilyHomologous superfamily
IPR036951 Aromatic amino acid hydroxylase superfamilyFamilyHomologous superfamily
IPR041912 Eukaryotic phenylalanine-4-hydroxylase, catalytic domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00120 PhenylalanineDrugbanksmall molecule
DB00360 SapropterinDrugbanksmall molecule
DB00368 NorepinephrineDrugbanksmall molecule
DB02562 Quinonoid 7,8-TetrahydrobiopterinDrugbanksmall molecule
DB03673 beta-2-Thienyl-L-alanineDrugbanksmall molecule
DB04400 L-erythro-7,8-dihydrobiopterinDrugbanksmall molecule
DB04419 D-norleucineDrugbanksmall molecule
DB06262 DroxidopaDrugbanksmall molecule
DB06778 Cupric sulfateSwissprotsmall molecule

Interactions

5 interactions