Entity Details

Primary name NEU2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP01185
EntryNameNEU2_HUMAN
FullNameVasopressin-neurophysin 2-copeptin
TaxID9606
Evidenceevidence at protein level
Length164
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesAVP

GO terms

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GOName
GO:0002125 maternal aggressive behavior
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0003084 positive regulation of systemic arterial blood pressure
GO:0003091 renal water homeostasis
GO:0004672 protein kinase activity
GO:0005102 signaling receptor binding
GO:0005184 neuropeptide hormone activity
GO:0005185 neurohypophyseal hormone activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005829 cytosol
GO:0006091 generation of precursor metabolites and energy
GO:0006833 water transport
GO:0007165 signal transduction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007267 cell-cell signaling
GO:0007621 negative regulation of female receptivity
GO:0007625 grooming behavior
GO:0007626 locomotory behavior
GO:0008284 positive regulation of cell population proliferation
GO:0010628 positive regulation of gene expression
GO:0014049 positive regulation of glutamate secretion
GO:0030141 secretory granule
GO:0030307 positive regulation of cell growth
GO:0030425 dendrite
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0031394 positive regulation of prostaglandin biosynthetic process
GO:0031894 V1A vasopressin receptor binding
GO:0031895 V1B vasopressin receptor binding
GO:0032849 positive regulation of cellular pH reduction
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033574 response to testosterone
GO:0035094 response to nicotine
GO:0035176 social behavior
GO:0035813 regulation of renal sodium excretion
GO:0042310 vasoconstriction
GO:0042538 hyperosmotic salinity response
GO:0042711 maternal behavior
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043084 penile erection
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045471 response to ethanol
GO:0045907 positive regulation of vasoconstriction
GO:0051970 negative regulation of transmission of nerve impulse
GO:0061024 membrane organization
GO:0070371 ERK1 and ERK2 cascade
GO:0070528 protein kinase C signaling
GO:0090201 negative regulation of release of cytochrome c from mitochondria

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000981 Neurohypophysial hormoneFamilyFamily
IPR022423 Neurohypophysial hormone, conserved siteSiteConserved site
IPR036387 Neurohypophysial hormone domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
125700 OMIMDiabetes insipidus, neurohypophyseal (NDI)A disease characterized by persistent thirst, polydipsia and polyuria. Affected individuals are apparently normal at birth, but characteristically develop symptoms of vasopressin deficiency during childhood. The disease is caused by variants affecting the gene represented in this entry.