Entity Details

Primary name TTHY_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP02766
EntryNameTTHY_HUMAN
FullNameTransthyretin
TaxID9606
Evidenceevidence at protein level
Length147
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesTTR

GO terms

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GOName
GO:0030198 extracellular matrix organization
GO:0032991 protein-containing complex
GO:0070062 extracellular exosome
GO:0044877 protein-containing complex binding
GO:0006144 purine nucleobase metabolic process
GO:0042802 identical protein binding
GO:0070324 thyroid hormone binding
GO:0070327 thyroid hormone transport
GO:0035578 azurophil granule lumen
GO:0005576 extracellular region
GO:0001523 retinoid metabolic process
GO:0005179 hormone activity
GO:0005615 extracellular space
GO:0043312 neutrophil degranulation
GO:1990000 amyloid fibril formation
GO:0042572 retinol metabolic process

Subcellular Location

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Subcellular Location
Cytoplasm
Secreted

Domains

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DomainNameCategoryType
IPR000895 Transthyretin/hydroxyisourate hydrolaseFamilyFamily
IPR023416 Transthyretin/hydroxyisourate hydrolase domainDomainDomain
IPR023418 Transthyretin, thyroxine binding siteSiteBinding site
IPR023419 Transthyretin, conserved siteSiteConserved site
IPR030178 TransthyretinFamilyFamily
IPR036817 Transthyretin/hydroxyisourate hydrolase domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00255 DiethylstilbestrolDrugbanksmall molecule
DB00279 LiothyronineDrugbanksmall molecule
DB00451 LevothyroxineDrugbanksmall molecule
DB00586 DiclofenacDrugbanksmall molecule
DB00861 DiflunisalDrugbanksmall molecule
DB01093 Dimethyl sulfoxideSwissprotsmall molecule
DB01583 LiotrixDrugbanksmall molecule
DB01593 ZincDrugbanksmall molecule
DB01645 GenisteinDrugbanksmall molecule
DB01751 Tetraiodothyroacetic acidSwissprotsmall molecule
DB01838 6,4'-Dihydroxy-3-Methyl-3',5'-DibromoflavoneSwissprotsmall molecule
DB02179 O-Trifluoromethylphenyl Anthranilic AcidSwissprotsmall molecule
DB02266 Flufenamic acidDrugbanksmall molecule
DB02417 2,4,6-TribromophenolSwissprotsmall molecule
DB02698 N-(M-Trifluoromethylphenyl) Phenoxazine-4,6-Dicarboxylic AcidSwissprotsmall molecule
DB02709 ResveratrolDrugbanksmall molecule
DB03167 PentabromophenolSwissprotsmall molecule
DB03239 3',5'-Dinitro-N-Acetyl-L-ThyronineSwissprotsmall molecule
DB03346 3,3',5,5'-tetrachlorobiphenyl-4,4'-diolDrugbanksmall molecule
DB03682 Dibenzofuran-4,6-Dicarboxylic AcidSwissprotsmall molecule
DB04474 8-anilinonaphthalene-1-sulfonic acidDrugbanksmall molecule
DB04674 2-HYDROXY-3,5-DIIODOBENZOIC ACIDDrugbanksmall molecule
DB04756 2-[(3,5-Dichloro-4-trioxidanylphenyl)amino]benzoic acidSwissprotsmall molecule
DB05235 NRP409Drugbanksmall molecule
DB05352 Fx-1006ASwissprotsmall molecule
DB06885 3-[({(1E)-[2-(trifluoromethyl)phenyl]methylidene}amino)oxy]propanoic acidSwissprotsmall molecule
DB06907 2-(2,6-DICHLOROPHENYL)-1,3-BENZOXAZOLE-6-CARBOXYLIC ACIDSwissprotsmall molecule
DB06935 2',6'-DIFLUOROBIPHENYL-4-CARBOXYLIC ACIDSwissprotsmall molecule
DB07047 2',4'-DICHLORO-4-HYDROXY-1,1'-BIPHENYL-3-CARBOXYLIC ACIDSwissprotsmall molecule
DB07176 1-Naphthylamine-5-sulfonic acidSwissprotsmall molecule
DB07201 (2S)-3-[(9H-fluoren-9-ylideneamino)oxy]-2-methylpropanoic acidSwissprotsmall molecule
DB07240 3-[(9H-fluoren-9-ylideneamino)oxy]propanoic acidSwissprotsmall molecule
DB07282 3-({[(1Z)-(2-methoxyphenyl)methylidene]amino}oxy)propanoic acidSwissprotsmall molecule
DB07693 N-(3,5-dibromo-4-hydroxyphenyl)-2,6-dimethylbenzamideSwissprotsmall molecule
DB07694 2,5-dichloro-N-(3,5-dibromo-4-hydroxyphenyl)benzamideSwissprotsmall molecule
DB07695 N-(3,5-dibromo-4-hydroxyphenyl)-4-hydroxy-3,5-dimethylbenzamideSwissprotsmall molecule
DB07753 3',5'-DIFLUOROBIPHENYL-4-CARBOXYLIC ACIDSwissprotsmall molecule
DB07775 3',5'-DIBROMO-2',4,4',6'-TETRAHYDROXY AURONESwissprotsmall molecule
DB07962 METHYL N-[(2',4'-DIFLUORO-4-HYDROXY-5-IODOBIPHENYL-3-YL)CARBONYL]-BETA-ALANINATESwissprotsmall molecule
DB07963 N-[(2',4'-DIFLUORO-4-HYDROXY-5-IODOBIPHENYL-3-YL)CARBONYL]-BETA-ALANINESwissprotsmall molecule
DB08100 2,6-dimethyl-4-[(E)-2-phenylethenyl]phenolSwissprotsmall molecule
DB08101 2,6-dibromo-4-[(E)-2-phenylethenyl]phenolSwissprotsmall molecule
DB08102 3,5-dibromobiphenyl-4-olSwissprotsmall molecule
DB08103 2,6-dibromo-4-phenoxyphenolSwissprotsmall molecule
DB08104 N-(3,5-dibromo-4-hydroxyphenyl)benzamideSwissprotsmall molecule
DB08205 4-(1,3-BENZOXAZOL-2-YL)-2,6-DIMETHYLPHENOLSwissprotsmall molecule
DB08206 4-(1,3-BENZOXAZOL-2-YL)-2,6-DIBROMOPHENOLSwissprotsmall molecule
DB08207 2-(3,5-DIMETHYLPHENYL)-1,3-BENZOXAZOLESwissprotsmall molecule
DB09100 Thyroid, porcineDrugbankbiotech
DB09130 CopperDrugbanksmall molecule
DB11644 TafamidisDrugbanksmall molecule
DB14487 Zinc acetateDrugbanksmall molecule
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule

Interactions

101 interactions

InteractorPartnerSourcesPublicationsLink
TTHY_HUMANDDR1_HUMANBioGRID, HPRD, IntAct16169070 details
TTHY_HUMANEF1A1_HUMANBioGRID, HPRD, IntAct16169070 details
TTHY_HUMANELP1_HUMANBioGRID, HPRD, IntAct, MINT16169070 21900206 details
TTHY_HUMANMARK3_HUMANBioGRID, HPRD, IntAct16169070 details
TTHY_HUMANCHD3_HUMANBioGRID, HPRD, IntAct, MINT16169070 21900206 details
TTHY_HUMANSETB1_HUMANBioGRID, HPRD, IntAct, MINT16169070 21900206 details
TTHY_HUMANVIME_HUMANBioGRID, HPRD, IntAct, MINT16169070 21900206 details
TTHY_HUMANGET4_HUMANBioGRID, HPRD, IntAct16169070 details
TTHY_HUMANHNRH3_HUMANBioGRID, HPRD, IntAct16169070 details
TTHY_HUMANPHYIP_HUMANBioGRID, HPRD, IntAct16169070 details
TTHY_HUMANFEZ1_HUMANBioGRID, HPRD, IntAct, MINT16169070 21900206 details
TTHY_HUMANSIAT6_HUMANHPRD, IntAct16169070 details
TTHY_HUMANATF4_HUMANBioGRID, HPRD, IntAct16189514 29892012 31515488 details
TTHY_HUMANRAGE_HUMANHPRD, MINT16716307 details
TTHY_HUMANPI3R5_HUMANIntAct18624398 details
TTHY_HUMANTTHY_HUMANBioGRID, DIP, HPRD, MINT11243784 16185074 19664600 19861125 21422279 21740906 21777382 22120741 23792159 23850452 25478940 details
TTHY_HUMANMT3_HUMANBioGRID, MINT20646067 details
TTHY_HUMANRET4_HUMANBioGRID, HPRD, IntAct, MINT11853533 12593674 21777382 29997244 574085 8089102 details
TTHY_HUMANA2MG_HUMANBioGRID, MINT21900206 details
TTHY_HUMANACTB_HUMANBioGRID, MINT21900206 details
TTHY_HUMANGET3_HUMANBioGRID, MINT21900206 details
TTHY_HUMANCREL2_HUMANMINT21900206 details
TTHY_HUMANERG28_HUMANBioGRID, MINT21900206 details
TTHY_HUMANCPNE6_HUMANBioGRID, MINT21900206 details
TTHY_HUMANCTND2_HUMANBioGRID, MINT21900206 details
TTHY_HUMANINP5K_HUMANBioGRID, MINT21900206 details
TTHY_HUMANCE126_HUMANBioGRID, MINT21900206 details
TTHY_HUMANTNR16_HUMANBioGRID, MINT21900206 details
TTHY_HUMANOTUB1_HUMANBioGRID, IntAct, MINT21900206 32814053 details
TTHY_HUMANKPCI_HUMANBioGRID, MINT21900206 details
TTHY_HUMANSYQ_HUMANBioGRID, MINT21900206 details
TTHY_HUMANRAI1_HUMANBioGRID, MINT21900206 details
TTHY_HUMANCAB45_HUMANBioGRID, MINT21900206 details
TTHY_HUMANSP110_HUMANBioGRID, MINT21900206 details
TTHY_HUMANF10A1_HUMANBioGRID, MINT21900206 details
TTHY_HUMANSUMO3_HUMANBioGRID, MINT21900206 details
TTHY_HUMANTAF1C_HUMANBioGRID, MINT21900206 details
TTHY_HUMANTAF5L_HUMANBioGRID, MINT21900206 details
TTHY_HUMANTBA1A_HUMANBioGRID, MINT21900206 details
TTHY_HUMANZBED1_HUMANBioGRID, MINT21900206 details
TTHY_HUMANNECA2_HUMANBioGRID, IntAct25416956 details
TTHY_HUMANCDR2_HUMANBioGRID, IntAct25416956 details
TTHY_HUMANATF5_HUMANBioGRID, IntAct32296183 details
TTHY_HUMANNDUA5_HUMANBioGRID, IntAct32296183 details
TTHY_HUMANCIA2B_HUMANIntAct32814053 details
TTHY_HUMANESRP1_HUMANIntAct32814053 details
TTHY_HUMANF135B_HUMANIntAct32814053 details
TTHY_HUMANKLH20_HUMANIntAct32814053 details
TTHY_HUMANARFG3_HUMANIntAct32814053 details
TTHY_HUMANSUMF2_HUMANIntAct32814053 details
TTHY_HUMANTB22A_HUMANIntAct32814053 details
TTHY_HUMANUB2E3_HUMANIntAct32814053 details
TTHY_HUMANFEZ2_HUMANIntAct32814053 details
TTHY_HUMANCSN3_HUMANIntAct32814053 details
TTHY_HUMANH31_HUMANIntAct32814053 details
TTHY_HUMANVDAC2_HUMANIntAct32814053 details
TTHY_HUMANTGM2_HUMANIntAct32814053 details
TTHY_HUMANTDG_HUMANIntAct32814053 details
TTHY_HUMANCLC11_HUMANIntAct32814053 details
TTHY_HUMANPRPS2_HUMANIntAct32814053 details
TTHY_HUMANUBL3_HUMANIntAct32814053 details
TTHY_HUMANP85A_HUMANBioGRID, IntAct18624398 32814053 details
TTHY_HUMANPALM_HUMANIntAct32814053 details
TTHY_HUMANMNDA_HUMANIntAct32814053 details
TTHY_HUMANKDSR_HUMANIntAct32814053 details
TTHY_HUMANKIF1A_HUMANIntAct32814053 details
TTHY_HUMANVATB1_HUMANIntAct32814053 details
TTHY_HUMANRN183_HUMANIntAct32814053 details
TTHY_HUMANISCA2_HUMANIntAct32814053 details
TTHY_HUMANTM129_HUMANIntAct32814053 details
TTHY_HUMANCOG8_HUMANIntAct32814053 details
TTHY_HUMANWDR83_HUMANIntAct32814053 details
TTHY_HUMANSPY4_HUMANIntAct32814053 details
TTHY_HUMANZXDC_HUMANIntAct32814053 details
TTHY_HUMANBRME1_HUMANIntAct32814053 details
TTHY_HUMANKCD15_HUMANIntAct32814053 details
TTHY_HUMANPALS1_HUMANIntAct32814053 details
TTHY_HUMANCCAR2_HUMANIntAct32814053 details
TTHY_HUMANOTU7B_HUMANIntAct32814053 details
TTHY_HUMANASB3_HUMANIntAct32814053 details
TTHY_HUMANUBR1_HUMANIntAct32814053 details
TTHY_HUMANMET27_HUMANIntAct32814053 details
TTHY_HUMANCNST_HUMANIntAct32814053 details
TTHY_HUMANVSX2_HUMANIntAct32814053 details
TTHY_HUMANGP141_HUMANIntAct32814053 details
TTHY_HUMANNUP43_HUMANIntAct32814053 details
TTHY_HUMANCP100_HUMANIntAct32814053 details
TTHY_HUMANA4_HUMANIntAct32814053 details
TTHY_HUMANPGBM_HUMANBioGRID, HPRD9307034 details
TTHY_HUMANBAG6_HUMANBioGRID21900206 26565908 details
TTHY_HUMANCLUS_HUMANBioGRID19664600 details
TTHY_HUMANRN115_HUMANBioGRID22844532 details
TTHY_HUMANHS90A_HUMANBioGRID28218749 details
TTHY_HUMANAPOA1_HUMANBioGRID, HPRD, IntAct10627502 15174051 details
TTHY_HUMANGOGA2_HUMANMINT17431395 details
TTHY_HUMANDERL1_HUMANBioGRID26565908 details
TTHY_HUMANDERL2_HUMANBioGRID26565908 details
TTHY_HUMANDERL3_HUMANBioGRID26565908 details
TTHY_HUMANTERA_HUMANBioGRID26565908 details
TTHY_HUMANSYVN1_HUMANBioGRID29743537 details
TTHY_HUMANLRP2_HUMANHPRD10982792 details