Entity Details

Primary name CP17A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP05093
EntryNameCP17A_HUMAN
FullNameSteroid 17-alpha-hydroxylase/17,20 lyase
TaxID9606
Evidenceevidence at protein level
Length508
SequenceStatuscomplete
DateCreated1987-08-13
DateModified2021-06-02

Ontological Relatives

GenesCYP17A1

GO terms

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GOName
GO:0004508 steroid 17-alpha-monooxygenase activity
GO:0005506 iron ion binding
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0006694 steroid biosynthetic process
GO:0006702 androgen biosynthetic process
GO:0006704 glucocorticoid biosynthetic process
GO:0007548 sex differentiation
GO:0008202 steroid metabolic process
GO:0019825 oxygen binding
GO:0020037 heme binding
GO:0042446 hormone biosynthetic process
GO:0042448 progesterone metabolic process
GO:0047442 17-alpha-hydroxyprogesterone aldolase activity

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane
Microsome membrane

Domains

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DomainNameCategoryType
IPR001128 Cytochrome P450FamilyFamily
IPR002401 Cytochrome P450, E-class, group IFamilyFamily
IPR017972 Cytochrome P450, conserved siteSiteConserved site
IPR036396 Cytochrome P450 superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00157 NADHDrugbanksmall molecule
DB00396 ProgesteroneDrugbanksmall molecule
DB00421 SpironolactoneDrugbanksmall molecule
DB00882 ClomifeneDrugbanksmall molecule
DB01026 KetoconazoleDrugbanksmall molecule
DB01234 DexamethasoneDrugbanksmall molecule
DB01424 AminophenazoneSwissprotsmall molecule
DB01708 PrasteroneDrugbanksmall molecule
DB02901 StanoloneDrugbanksmall molecule
DB04630 AldosteroneDrugbanksmall molecule
DB05812 AbirateroneDrugbanksmall molecule
DB09061 CannabidiolDrugbanksmall molecule
DB14009 Medical CannabisDrugbankbiotech
DB14011 NabiximolsDrugbanksmall molecule
DB14649 Dexamethasone acetateDrugbanksmall molecule