Entity Details

Primary name KPCG_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP05129
EntryNameKPCG_HUMAN
FullNameProtein kinase C gamma type
TaxID9606
Evidenceevidence at protein level
Length697
SequenceStatuscomplete
DateCreated1987-08-13
DateModified2021-06-02

Ontological Relatives

GenesPRKCG

GO terms

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GOName
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004697 protein kinase C activity
GO:0004698 calcium-dependent protein kinase C activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0006468 protein phosphorylation
GO:0007268 chemical synaptic transmission
GO:0007611 learning or memory
GO:0007635 chemosensory behavior
GO:0008270 zinc ion binding
GO:0009636 response to toxic substance
GO:0014069 postsynaptic density
GO:0016310 phosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0030168 platelet activation
GO:0030425 dendrite
GO:0031397 negative regulation of protein ubiquitination
GO:0032095 regulation of response to food
GO:0032425 positive regulation of mismatch repair
GO:0035556 intracellular signal transduction
GO:0042177 negative regulation of protein catabolic process
GO:0042752 regulation of circadian rhythm
GO:0043278 response to morphine
GO:0043524 negative regulation of neuron apoptotic process
GO:0044305 calyx of Held
GO:0046777 protein autophosphorylation
GO:0048265 response to pain
GO:0048471 perinuclear region of cytoplasm
GO:0048511 rhythmic process
GO:0050764 regulation of phagocytosis
GO:0060291 long-term synaptic potentiation
GO:0060384 innervation
GO:0097060 synaptic membrane
GO:0099171 presynaptic modulation of chemical synaptic transmission
GO:0099523 presynaptic cytosol
GO:0099524 postsynaptic cytosol
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1901799 negative regulation of proteasomal protein catabolic process
GO:1990911 response to psychosocial stress
GO:2000300 regulation of synaptic vesicle exocytosis

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cell projection
Cytoplasm

Domains

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DomainNameCategoryType
IPR000008 C2 domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR000961 AGC-kinase, C-terminalDomainDomain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR014375 Protein kinase C, alpha/beta/gamma typesFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR017892 Protein kinase, C-terminalDomainDomain
IPR020454 Diacylglycerol/phorbol-ester bindingDomainDomain
IPR035892 C2 domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00675 TamoxifenDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

74 interactions

InteractorPartnerSourcesPublicationsLink
KPCG_HUMANPICK1_HUMANBioGRID, HPRD, IntAct16713569 details
KPCG_HUMANNOXA1_HUMANBioGRID, HPRD, IntAct16713569 details
KPCG_HUMANEXOC5_HUMANBioGRID, HPRD, IntAct16713569 details
KPCG_HUMANCCHCR_HUMANBioGRID, HPRD, IntAct16713569 details
KPCG_HUMANPTN1_HUMANMINT17092689 details
KPCG_HUMANSAMD3_HUMANIntAct32814053 details
KPCG_HUMANTCP1L_HUMANIntAct32814053 details
KPCG_HUMANF167A_HUMANIntAct32814053 details
KPCG_HUMANPIAS1_HUMANIntAct32814053 details
KPCG_HUMANK1C19_HUMANIntAct32814053 details
KPCG_HUMANGRIA4_HUMANBioGRID, HPRD12471040 details
KPCG_HUMANRGS2_HUMANBioGRID, HPRD11063746 details
KPCG_HUMANTIAM1_HUMANBioGRID, HPRD10212259 details
KPCG_HUMANAFAP1_HUMANBioGRID, HPRD12134071 details
KPCG_HUMANDDX58_HUMANBioGRID22114345 details
KPCG_HUMANTOP2A_HUMANBioGRID, HPRD12569090 7499337 details
KPCG_HUMANA4_HUMANBioGRID21832049 details
KPCG_HUMANSDC2_HUMANBioGRID, HPRD9244383 details
KPCG_HUMANITB2_HUMANBioGRID11700305 details
KPCG_HUMANGSK3A_HUMANBioGRID, HPRD11035810 11749387 11884598 12054501 details
KPCG_HUMANCASR_HUMANBioGRID, HPRD9694886 details
KPCG_HUMANARHGP_HUMANBioGRID20395553 details
KPCG_HUMANRBP10_HUMANBioGRID20395553 details
KPCG_HUMANGFAP_HUMANBioGRID20395553 details
KPCG_HUMANHSP74_HUMANBioGRID20395553 details
KPCG_HUMANEPHB1_HUMANBioGRID20395553 details
KPCG_HUMANSCN3A_HUMANBioGRID20395553 details
KPCG_HUMANTRIM5_HUMANBioGRID20395553 details
KPCG_HUMANDAB2_HUMANBioGRID, HPRD10542228 details
KPCG_HUMANCTNB1_HUMANBioGRID25639486 details
KPCG_HUMANSMUF1_HUMANBioGRID20804422 details
KPCG_HUMANUBE2T_HUMANBioGRID28162934 details
KPCG_HUMANFBX7_HUMANBioGRID27503909 details
KPCG_HUMANDNJC5_HUMANBioGRID29167402 details
KPCG_HUMANARHG7_HUMANBioGRID29167402 details
KPCG_HUMANTAU_HUMANBioGRID11104762 details
KPCG_HUMANPDLI5_HUMANHPRD8940095 details
KPCG_HUMANHS90B_HUMANBioGRID, IntAct22939624 31980649 details
KPCG_HUMAN1433G_HUMANBioGRID, HPRD10433554 details
KPCG_HUMANGBRA1_HUMANBioGRID, HPRD12091471 details
KPCG_HUMANGBRA4_HUMANBioGRID, HPRD12091471 details
KPCG_HUMANIBTK_HUMANBioGRID21482705 details
KPCG_HUMANRANB9_HUMANBioGRID20395553 details
KPCG_HUMANVTNC_HUMANHPRD9030777 details
KPCG_HUMAN1433B_HUMANHPRD14676191 details
KPCG_HUMANPA2G4_HUMANHPRD11325528 details
KPCG_HUMANNEUG_HUMANHPRD8080473 details
KPCG_HUMANCYH2_HUMANHPRD10531036 details
KPCG_HUMANNMDE4_HUMANHPRD10862698 details
KPCG_HUMANOCLN_HUMANHPRD11502742 details
KPCG_HUMANSTXB1_HUMANHPRD12519779 12950453 8631738 details
KPCG_HUMANPNMA1_HUMANHPRD14676191 details
KPCG_HUMANPARD3_HUMANHPRD14676191 details
KPCG_HUMANPAR6A_HUMANHPRD14676191 details
KPCG_HUMANPEBP1_HUMANHPRD12551925 14654844 details
KPCG_HUMANMARK4_HUMANHPRD14676191 details
KPCG_HUMANHABP4_HUMANHPRD14699138 details
KPCG_HUMANNMDZ1_HUMANHPRD10862698 details
KPCG_HUMANPP14A_HUMANHPRD15003508 details
KPCG_HUMANPAR6B_HUMANHPRD14676191 details
KPCG_HUMANARBK1_HUMANHPRD11042191 details
KPCG_HUMANGRM5_HUMANHPRD15894802 details
KPCG_HUMANCDC42_HUMANHPRD14676191 details
KPCG_HUMANCLAT_HUMANHPRD15381704 details
KPCG_HUMANCXA3_HUMANHPRD15467523 details
KPCG_HUMANIRS1_HUMANHPRD15364919 details
KPCG_HUMANANXA7_HUMANHPRD11278415 details
KPCG_HUMANCXA1_HUMANHPRD10871288 details
KPCG_HUMANDVL2_HUMANHPRD12958364 details
KPCG_HUMAN1433E_HUMANHPRD15459208 details
KPCG_HUMANNUMB_HUMANHPRD17203073 details
KPCG_HUMANIF4E_HUMANHPRD8662663 details
KPCG_HUMANNMDE2_HUMANHPRD11306676 12147342 8940188 details
KPCG_HUMANCD5_HUMANHPRD11123317 details