Entity Details

Primary name GPX1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP07203
EntryNameGPX1_HUMAN
FullNameGlutathione peroxidase 1
TaxID9606
Evidenceevidence at protein level
Length203
SequenceStatuscomplete
DateCreated1988-04-01
DateModified2021-06-02

Ontological Relatives

GenesGPX1

GO terms

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GOName
GO:0001659 temperature homeostasis
GO:0001885 endothelial cell development
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0004601 peroxidase activity
GO:0004602 glutathione peroxidase activity
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0006195 purine nucleotide catabolic process
GO:0006641 triglyceride metabolic process
GO:0006749 glutathione metabolic process
GO:0007605 sensory perception of sound
GO:0009410 response to xenobiotic stimulus
GO:0009609 response to symbiotic bacterium
GO:0009650 UV protection
GO:0010269 response to selenium ion
GO:0010332 response to gamma radiation
GO:0017124 SH3 domain binding
GO:0018158 protein oxidation
GO:0019369 arachidonic acid metabolic process
GO:0019372 lipoxygenase pathway
GO:0033194 response to hydroperoxide
GO:0033599 regulation of mammary gland epithelial cell proliferation
GO:0034599 cellular response to oxidative stress
GO:0040029 regulation of gene expression, epigenetic
GO:0042311 vasodilation
GO:0042542 response to hydrogen peroxide
GO:0042744 hydrogen peroxide catabolic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043403 skeletal muscle tissue regeneration
GO:0043534 blood vessel endothelial cell migration
GO:0045444 fat cell differentiation
GO:0045454 cell redox homeostasis
GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity
GO:0048741 skeletal muscle fiber development
GO:0051450 myoblast proliferation
GO:0051702 biological process involved in interaction with symbiont
GO:0051897 positive regulation of protein kinase B signaling
GO:0060047 heart contraction
GO:0060055 angiogenesis involved in wound healing
GO:0061136 regulation of proteasomal protein catabolic process
GO:0090201 negative regulation of release of cytochrome c from mitochondria
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:1902905 positive regulation of supramolecular fiber organization

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000889 Glutathione peroxidaseFamilyFamily
IPR029759 Glutathione peroxidase active siteSiteActive site
IPR029760 Glutathione peroxidase conserved siteSiteConserved site
IPR036249 Thioredoxin-like superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00143 GlutathioneDrugbanksmall molecule
DB03310 Glutathione disulfideDrugbanksmall molecule
DB09061 CannabidiolDrugbanksmall molecule
DB09221 PolaprezincDrugbanksmall molecule
DB11091 Hydrogen peroxideSwissprotsmall molecule
DB11127 Selenious acidSwissprotsmall molecule
DB11590 ThimerosalDrugbanksmall molecule
DB14009 Medical CannabisDrugbankbiotech
DB14011 NabiximolsDrugbanksmall molecule

Interactions

5 interactions