Entity Details

Primary name ADH4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP08319
EntryNameADH4_HUMAN
FullNameAll-trans-retinol dehydrogenase [NAD(+)] ADH4
TaxID9606
Evidenceevidence at protein level
Length380
SequenceStatuscomplete
DateCreated1988-08-01
DateModified2021-06-02

Ontological Relatives

GenesADH4

GO terms

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GOName
GO:0001523 retinoid metabolic process
GO:0003960 NADPH:quinone reductase activity
GO:0004022 alcohol dehydrogenase (NAD+) activity
GO:0004024 alcohol dehydrogenase activity, zinc-dependent
GO:0004032 alditol:NADP+ 1-oxidoreductase activity
GO:0004745 NAD-retinol dehydrogenase activity
GO:0005503 all-trans retinal binding
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006066 alcohol metabolic process
GO:0006069 ethanol oxidation
GO:0006081 cellular aldehyde metabolic process
GO:0008270 zinc ion binding
GO:0010430 fatty acid omega-oxidation
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0019115 benzaldehyde dehydrogenase [NAD(P)+] activity
GO:0019841 retinol binding
GO:0035276 ethanol binding
GO:0042572 retinol metabolic process
GO:0046164 alcohol catabolic process
GO:0046294 formaldehyde catabolic process
GO:0051287 NAD binding
GO:0051903 S-(hydroxymethyl)glutathione dehydrogenase activity
GO:1901661 quinone metabolic process

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR002328 Alcohol dehydrogenase, zinc-type, conserved siteSiteConserved site
IPR011032 GroES-like superfamilyFamilyHomologous superfamily
IPR013149 Alcohol dehydrogenase, C-terminalDomainDomain
IPR013154 Alcohol dehydrogenase, N-terminalDomainDomain
IPR020843 Polyketide synthase, enoylreductase domainDomainDomain
IPR028632 Alcohol dehydrogenase family, zinc-type, class-II subfamilyFamilyFamily
IPR036291 NAD(P)-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00157 NADHDrugbanksmall molecule
DB00898 EthanolDrugbanksmall molecule
DB03559 CyclohexylformamideDrugbanksmall molecule

Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
ADH4_HUMANRL35_HUMANBioGRID, IntAct21988832 details
ADH4_HUMANTRI69_HUMANIntAct32296183 details
ADH4_HUMANA4_HUMANBioGRID21832049 details