Entity Details

Primary name LKHA4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP09960
EntryNameLKHA4_HUMAN
FullNameLeukotriene A-4 hydrolase
TaxID9606
Evidenceevidence at protein level
Length611
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesLTA4H

GO terms

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GOName
GO:0043312 neutrophil degranulation
GO:0004177 aminopeptidase activity
GO:0044267 cellular protein metabolic process
GO:0045148 tripeptide aminopeptidase activity
GO:0005634 nucleus
GO:0070006 metalloaminopeptidase activity
GO:0003723 RNA binding
GO:0008270 zinc ion binding
GO:1904813 ficolin-1-rich granule lumen
GO:0008233 peptidase activity
GO:0019370 leukotriene biosynthetic process
GO:0005654 nucleoplasm
GO:0004463 leukotriene-A4 hydrolase activity
GO:1904724 tertiary granule lumen
GO:0005576 extracellular region
GO:0006691 leukotriene metabolic process
GO:0042759 long-chain fatty acid biosynthetic process
GO:0004301 epoxide hydrolase activity
GO:0070062 extracellular exosome
GO:0005829 cytosol
GO:0043171 peptide catabolic process

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR001930 Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolaseFamilyFamily
IPR012777 Leukotriene A4 hydrolase/leucine aminopeptidaseFamilyFamily
IPR014782 Peptidase M1, membrane alanine aminopeptidaseDomainDomain
IPR015211 Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminalDomainDomain
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR027268 Peptidase M4/M1, CTD superfamilyFamilyHomologous superfamily
IPR034015 Aminopeptidase, leukotriene A4 hydrolase-likeFamilyFamily
IPR038502 Peptidase M1, LTA-4 hydrolase/aminopeptidase, C-terminal domain superfamilyFamilyHomologous superfamily
IPR042097 Aminopeptidase N-like , N-terminalFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01197 CaptoprilDrugbanksmall molecule
DB02062 N-[3-[(1-Aminoethyl)(Hydroxy)Phosphoryl]-2-(1,1'-Biphenyl-4-Ylmethyl)Propanoyl]AlanineDrugbanksmall molecule
DB02352 3-(Benzyloxy)Pyridin-2-AmineDrugbanksmall molecule
DB03366 ImidazoleDrugbanksmall molecule
DB03424 UbenimexDrugbanksmall molecule
DB05177 DG051Drugbanksmall molecule
DB06828 5-[2-(1H-pyrrol-1-yl)ethoxy]-1H-indoleDrugbanksmall molecule
DB06851 N-(pyridin-3-ylmethyl)anilineDrugbanksmall molecule
DB06917 (4-fluorophenyl)(pyridin-4-yl)methanoneDrugbanksmall molecule
DB07094 1-(2,2'-bithiophen-5-yl)methanamineDrugbanksmall molecule
DB07099 N-[4-(benzyloxy)phenyl]glycinamideDrugbanksmall molecule
DB07102 (2S)-2-amino-5-oxo-5-[(4-phenylmethoxyphenyl)amino]pentanoic acidDrugbanksmall molecule
DB07104 4-amino-N-[4-(benzyloxy)phenyl]butanamideDrugbanksmall molecule
DB07196 N-methyl-1-(2-thiophen-2-ylphenyl)methanamineDrugbanksmall molecule
DB07237 {4-[(2R)-pyrrolidin-2-ylmethoxy]phenyl}(4-thiophen-3-ylphenyl)methanoneDrugbanksmall molecule
DB07258 (R)-pyridin-4-yl[4-(2-pyrrolidin-1-ylethoxy)phenyl]methanolDrugbanksmall molecule
DB07259 1-(4-thiophen-2-ylphenyl)methanamineDrugbanksmall molecule
DB07260 N-benzyl-4-[(2R)-pyrrolidin-2-ylmethoxy]anilineDrugbanksmall molecule
DB07292 4-(2-amino-1,3-thiazol-4-yl)phenolDrugbanksmall molecule
DB08040 KelatorphanDrugbanksmall molecule
DB08466 5-[2-(4-hydroxyphenyl)ethyl]benzene-1,3-diolDrugbanksmall molecule
DB11781 TosedostatDrugbanksmall molecule