Entity Details

Primary name CP2D6_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP10635
EntryNameCP2D6_HUMAN
FullNameCytochrome P450 2D6
TaxID9606
Evidenceevidence at protein level
Length497
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesCYP2D6

GO terms

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GOName
GO:0090350 negative regulation of cellular organofluorine metabolic process
GO:0008202 steroid metabolic process
GO:0008395 steroid hydroxylase activity
GO:0020037 heme binding
GO:0008203 cholesterol metabolic process
GO:0042738 exogenous drug catabolic process
GO:0009804 coumarin metabolic process
GO:0016491 oxidoreductase activity
GO:0043231 intracellular membrane-bounded organelle
GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0006805 xenobiotic metabolic process
GO:0009822 alkaloid catabolic process
GO:0017144 drug metabolic process
GO:0062187 anandamide 8,9 epoxidase activity
GO:0005739 mitochondrion
GO:0070989 oxidative demethylation
GO:0008210 estrogen metabolic process
GO:0062189 anandamide 14,15 epoxidase activity
GO:0042572 retinol metabolic process
GO:0051100 negative regulation of binding
GO:0062188 anandamide 11,12 epoxidase activity
GO:0005783 endoplasmic reticulum
GO:0006082 organic acid metabolic process
GO:0042759 long-chain fatty acid biosynthetic process
GO:0019369 arachidonic acid metabolic process
GO:0046483 heterocycle metabolic process
GO:0004497 monooxygenase activity
GO:0005789 endoplasmic reticulum membrane
GO:0005737 cytoplasm
GO:0033076 isoquinoline alkaloid metabolic process
GO:0042737 drug catabolic process
GO:0009820 alkaloid metabolic process
GO:0005506 iron ion binding
GO:0016098 monoterpenoid metabolic process

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane
Microsome membrane

Domains

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DomainNameCategoryType
IPR001128 Cytochrome P450FamilyFamily
IPR002401 Cytochrome P450, E-class, group IFamilyFamily
IPR008069 Cytochrome P450, E-class, group I, CYP2D-likeFamilyFamily
IPR017972 Cytochrome P450, conserved siteSiteConserved site
IPR036396 Cytochrome P450 superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00022 Peginterferon alfa-2bDrugbankbiotech
DB00091 CyclosporineDrugbanksmall molecule
DB00176 FluvoxamineDrugbanksmall molecule
DB00182 AmphetamineDrugbanksmall molecule
DB00184 NicotineDrugbanksmall molecule
DB00185 CevimelineDrugbanksmall molecule
DB00187 EsmololDrugbanksmall molecule
DB00188 BortezomibDrugbanksmall molecule
DB00193 TramadolDrugbanksmall molecule
DB00195 BetaxololDrugbanksmall molecule
DB00201 CaffeineDrugbanksmall molecule
DB00203 SildenafilDrugbanksmall molecule
DB00208 TiclopidineDrugbanksmall molecule
DB00209 TrospiumDrugbanksmall molecule
DB00211 MidodrineDrugbanksmall molecule
DB00215 CitalopramDrugbanksmall molecule
DB00216 EletriptanDrugbanksmall molecule
DB00220 NelfinavirDrugbanksmall molecule
DB00224 IndinavirDrugbanksmall molecule
DB00234 ReboxetineDrugbanksmall molecule
DB00238 NevirapineDrugbanksmall molecule
DB00243 RanolazineDrugbanksmall molecule
DB00252 PhenytoinDrugbanksmall molecule
DB00257 ClotrimazoleDrugbanksmall molecule
DB00259 SulfanilamideDrugbanksmall molecule
DB00264 MetoprololDrugbanksmall molecule
DB00277 TheophyllineDrugbanksmall molecule
DB00281 LidocaineDrugbanksmall molecule
DB00283 ClemastineDrugbanksmall molecule
DB00285 VenlafaxineDrugbanksmall molecule
DB00289 AtomoxetineDrugbanksmall molecule
DB00297 BupivacaineDrugbanksmall molecule
DB00316 AcetaminophenDrugbanksmall molecule
DB00317 GefitinibDrugbanksmall molecule
DB00318 CodeineDrugbanksmall molecule
DB00321 AmitriptylineDrugbanksmall molecule
DB00333 MethadoneDrugbanksmall molecule
DB00334 OlanzapineDrugbanksmall molecule
DB00335 AtenololDrugbanksmall molecule
DB00338 OmeprazoleDrugbanksmall molecule
DB00342 TerfenadineDrugbanksmall molecule
DB00343 DiltiazemDrugbanksmall molecule
DB00349 ClobazamDrugbanksmall molecule
DB00356 ChlorzoxazoneDrugbanksmall molecule
DB00361 VinorelbineDrugbanksmall molecule
DB00363 ClozapineDrugbanksmall molecule
DB00370 MirtazapineDrugbanksmall molecule
DB00373 TimololDrugbanksmall molecule
DB00377 PalonosetronDrugbanksmall molecule
DB00379 MexiletineDrugbanksmall molecule
DB00381 AmlodipineDrugbanksmall molecule
DB00396 ProgesteroneDrugbanksmall molecule
DB00398 SorafenibDrugbanksmall molecule
DB00409 RemoxiprideDrugbanksmall molecule
DB00412 RosiglitazoneDrugbanksmall molecule
DB00420 PromazineDrugbanksmall molecule
DB00425 ZolpidemDrugbanksmall molecule
DB00433 ProchlorperazineDrugbanksmall molecule
DB00439 CerivastatinDrugbanksmall molecule
DB00448 LansoprazoleDrugbanksmall molecule
DB00454 MeperidineDrugbanksmall molecule
DB00455 LoratadineDrugbanksmall molecule
DB00458 ImipramineDrugbanksmall molecule
DB00468 QuinineDrugbanksmall molecule
DB00472 FluoxetineDrugbanksmall molecule
DB00476 DuloxetineDrugbanksmall molecule
DB00477 ChlorpromazineDrugbanksmall molecule
DB00482 CelecoxibDrugbanksmall molecule
DB00489 SotalolDrugbanksmall molecule
DB00490 BuspironeDrugbanksmall molecule
DB00494 EntacaponeDrugbanksmall molecule
DB00496 DarifenacinDrugbanksmall molecule
DB00497 OxycodoneDrugbanksmall molecule
DB00501 CimetidineDrugbanksmall molecule
DB00502 HaloperidolDrugbanksmall molecule
DB00503 RitonavirDrugbanksmall molecule
DB00514 DextromethorphanDrugbanksmall molecule
DB00521 CarteololDrugbanksmall molecule
DB00528 LercanidipineDrugbanksmall molecule
DB00530 ErlotinibDrugbanksmall molecule
DB00532 MephenytoinDrugbanksmall molecule
DB00540 NortriptylineDrugbanksmall molecule
DB00543 AmoxapineDrugbanksmall molecule
DB00557 HydroxyzineDrugbanksmall molecule
DB00568 CinnarizineDrugbanksmall molecule
DB00570 VinblastineDrugbanksmall molecule
DB00571 PropranololDrugbanksmall molecule
DB00574 FenfluramineDrugbanksmall molecule
DB00575 ClonidineDrugbanksmall molecule
DB00590 DoxazosinDrugbanksmall molecule
DB00592 PiperazineDrugbanksmall molecule
DB00598 LabetalolDrugbanksmall molecule
DB00604 CisaprideDrugbanksmall molecule
DB00608 ChloroquineDrugbanksmall molecule
DB00613 AmodiaquineDrugbanksmall molecule
DB00619 ImatinibDrugbanksmall molecule
DB00622 NicardipineDrugbanksmall molecule
DB00623 FluphenazineDrugbanksmall molecule
DB00625 EfavirenzDrugbanksmall molecule
DB00627 NiacinDrugbanksmall molecule
DB00633 DexmedetomidineDrugbanksmall molecule
DB00637 AstemizoleDrugbanksmall molecule
DB00641 SimvastatinDrugbanksmall molecule
DB00647 DextropropoxypheneDrugbanksmall molecule
DB00656 TrazodoneDrugbanksmall molecule
DB00661 VerapamilDrugbanksmall molecule
DB00674 GalantamineDrugbanksmall molecule
DB00675 TamoxifenDrugbanksmall molecule
DB00679 ThioridazineDrugbanksmall molecule
DB00699 NicergolineDrugbanksmall molecule
DB00701 AmprenavirDrugbanksmall molecule
DB00705 DelavirdineDrugbanksmall molecule
DB00706 TamsulosinDrugbanksmall molecule
DB00715 ParoxetineDrugbanksmall molecule
DB00726 TrimipramineDrugbanksmall molecule
DB00731 NateglinideDrugbanksmall molecule
DB00734 RisperidoneDrugbanksmall molecule
DB00737 MeclizineDrugbanksmall molecule
DB00738 PentamidineDrugbanksmall molecule
DB00751 EpinastineDrugbanksmall molecule
DB00752 TranylcypromineDrugbanksmall molecule
DB00757 DolasetronDrugbanksmall molecule
DB00763 MethimazoleDrugbanksmall molecule
DB00780 PhenelzineDrugbanksmall molecule
DB00792 TripelennamineDrugbanksmall molecule
DB00805 MinaprineDrugbanksmall molecule
DB00810 BiperidenDrugbanksmall molecule
DB00834 MifepristoneDrugbanksmall molecule
DB00836 LoperamideDrugbanksmall molecule
DB00843 DonepezilDrugbanksmall molecule
DB00845 ClofazimineDrugbanksmall molecule
DB00850 PerphenazineDrugbanksmall molecule
DB00857 TerbinafineDrugbanksmall molecule
DB00863 RanitidineDrugbanksmall molecule
DB00866 AlprenololDrugbanksmall molecule
DB00904 OndansetronDrugbanksmall molecule
DB00907 CocaineDrugbanksmall molecule
DB00908 QuinidineDrugbanksmall molecule
DB00914 PhenforminDrugbanksmall molecule
DB00918 AlmotriptanDrugbanksmall molecule
DB00921 BuprenorphineDrugbanksmall molecule
DB00924 CyclobenzaprineDrugbanksmall molecule
DB00932 TipranavirDrugbanksmall molecule
DB00933 MesoridazineDrugbanksmall molecule
DB00934 MaprotilineDrugbanksmall molecule
DB00951 IsoniazidDrugbanksmall molecule
DB00956 HydrocodoneDrugbanksmall molecule
DB00960 PindololDrugbanksmall molecule
DB00972 AzelastineDrugbanksmall molecule
DB00983 FormoterolDrugbanksmall molecule
DB00997 DoxorubicinDrugbanksmall molecule
DB01005 HydroxyureaDrugbanksmall molecule
DB01012 CinacalcetDrugbanksmall molecule
DB01023 FelodipineDrugbanksmall molecule
DB01026 KetoconazoleDrugbanksmall molecule
DB01028 MethoxyfluraneDrugbanksmall molecule
DB01035 ProcainamideDrugbanksmall molecule
DB01036 TolterodineDrugbanksmall molecule
DB01037 SelegilineDrugbanksmall molecule
DB01062 OxybutyninDrugbanksmall molecule
DB01069 PromethazineDrugbanksmall molecule
DB01071 MequitazineDrugbanksmall molecule
DB01074 PerhexilineDrugbanksmall molecule
DB01075 DiphenhydramineDrugbanksmall molecule
DB01076 AtorvastatinDrugbanksmall molecule
DB01079 TegaserodDrugbanksmall molecule
DB01087 PrimaquineDrugbanksmall molecule
DB01093 Dimethyl sulfoxideSwissprotsmall molecule
DB01095 FluvastatinDrugbanksmall molecule
DB01096 OxamniquineSwissprotsmall molecule
DB01100 PimozideDrugbanksmall molecule
DB01104 SertralineDrugbanksmall molecule
DB01110 MiconazoleDrugbanksmall molecule
DB01114 ChlorpheniramineDrugbanksmall molecule
DB01115 NifedipineDrugbanksmall molecule
DB01118 AmiodaroneDrugbanksmall molecule
DB01128 BicalutamideDrugbanksmall molecule
DB01129 RabeprazoleDrugbanksmall molecule
DB01131 ProguanilDrugbanksmall molecule
DB01136 CarvedilolDrugbanksmall molecule
DB01142 DoxepinDrugbanksmall molecule
DB01149 NefazodoneDrugbanksmall molecule
DB01151 DesipramineDrugbanksmall molecule
DB01156 BupropionDrugbanksmall molecule
DB01166 CilostazolDrugbanksmall molecule
DB01171 MoclobemideDrugbanksmall molecule
DB01173 OrphenadrineDrugbanksmall molecule
DB01175 EscitalopramDrugbanksmall molecule
DB01177 IdarubicinDrugbanksmall molecule
DB01182 PropafenoneDrugbanksmall molecule
DB01184 DomperidoneDrugbanksmall molecule
DB01191 DexfenfluramineDrugbanksmall molecule
DB01192 OxymorphoneDrugbanksmall molecule
DB01193 AcebutololDrugbanksmall molecule
DB01195 FlecainideDrugbanksmall molecule
DB01206 LomustineDrugbanksmall molecule
DB01210 LevobunololDrugbanksmall molecule
DB01214 MetipranololDrugbanksmall molecule
DB01218 HalofantrineDrugbanksmall molecule
DB01224 QuetiapineDrugbanksmall molecule
DB01228 EncainideDrugbanksmall molecule
DB01232 SaquinavirDrugbanksmall molecule
DB01233 MetoclopramideDrugbanksmall molecule
DB01238 AripiprazoleDrugbanksmall molecule
DB01242 ClomipramineDrugbanksmall molecule
DB01244 BepridilDrugbanksmall molecule
DB01255 LisdexamfetamineDrugbanksmall molecule
DB01264 DarunavirDrugbanksmall molecule
DB01267 PaliperidoneDrugbanksmall molecule
DB01274 ArformoterolDrugbanksmall molecule
DB01295 BevantololDrugbanksmall molecule
DB01297 PractololDrugbanksmall molecule
DB01323 St. John's WortSwissprotsmall molecule
DB01359 PenbutololDrugbanksmall molecule
DB01388 MibefradilDrugbanksmall molecule
DB01392 YohimbineDrugbanksmall molecule
DB01403 MethotrimeprazineDrugbanksmall molecule
DB01409 TiotropiumDrugbanksmall molecule
DB01410 CiclesonideDrugbanksmall molecule
DB01424 AminophenazoneSwissprotsmall molecule
DB01429 AprindineDrugbanksmall molecule
DB01435 AntipyrineDrugbanksmall molecule
DB01454 MidomafetamineDrugbanksmall molecule
DB01466 EthylmorphineDrugbanksmall molecule
DB01472 4-MethoxyamphetamineDrugbanksmall molecule
DB01551 DihydrocodeineSwissprotsmall molecule
DB01562 1-(2-Phenylethyl)-4-phenyl-4-acetoxypiperidineSwissprotsmall molecule
DB01576 DextroamphetamineDrugbanksmall molecule
DB01577 MetamfetamineDrugbanksmall molecule
DB01580 OxprenololDrugbanksmall molecule
DB01590 EverolimusDrugbanksmall molecule
DB01591 SolifenacinDrugbanksmall molecule
DB01601 LopinavirDrugbanksmall molecule
DB01611 HydroxychloroquineDrugbanksmall molecule
DB01621 PipotiazineDrugbanksmall molecule
DB01623 ThiothixeneDrugbanksmall molecule
DB01624 ZuclopenthixolDrugbanksmall molecule
DB01628 EtoricoxibDrugbanksmall molecule
DB02701 NicotinamideDrugbanksmall molecule
DB02703 Fusidic acidDrugbanksmall molecule
DB03783 PhenacetinDrugbanksmall molecule
DB04818 IproniazidSwissprotsmall molecule
DB04829 Lysergic acid diethylamideDrugbanksmall molecule
DB04840 DebrisoquineDrugbanksmall molecule
DB04841 FlunarizineDrugbanksmall molecule
DB04844 TetrabenazineDrugbanksmall molecule
DB04846 CeliprololDrugbanksmall molecule
DB04855 DronedaroneDrugbanksmall molecule
DB04861 NebivololDrugbanksmall molecule
DB04868 NilotinibDrugbanksmall molecule
DB04871 LorcaserinDrugbanksmall molecule
DB04884 DapoxetineDrugbanksmall molecule
DB04889 BicifadineDrugbanksmall molecule
DB04905 TesmilifeneDrugbanksmall molecule
DB04911 OritavancinSwissprotsmall molecule
DB04920 ClevidipineDrugbanksmall molecule
DB04938 OspemifeneDrugbanksmall molecule
DB04946 IloperidoneDrugbanksmall molecule
DB04948 LofexidineDrugbanksmall molecule
DB04951 PirfenidoneSwissprotsmall molecule
DB04957 AzimilideDrugbanksmall molecule
DB05109 TrabectedinSwissprotsmall molecule
DB05271 RotigotineDrugbanksmall molecule
DB05812 AbirateroneDrugbanksmall molecule
DB06016 CariprazineDrugbanksmall molecule
DB06137 TirbanibulinDrugbanksmall molecule
DB06144 SertindoleDrugbanksmall molecule
DB06148 MianserinDrugbanksmall molecule
DB06203 AlogliptinDrugbanksmall molecule
DB06204 TapentadolDrugbanksmall molecule
DB06216 AsenapineDrugbanksmall molecule
DB06217 VernakalantDrugbanksmall molecule
DB06287 TemsirolimusDrugbanksmall molecule
DB06292 DapagliflozinDrugbanksmall molecule
DB06370 IndisulamSwissprotsmall molecule
DB06412 OxymetholoneDrugbanksmall molecule
DB06506 RepinotanDrugbanksmall molecule
DB06512 DeramciclaneDrugbanksmall molecule
DB06589 PazopanibDrugbanksmall molecule
DB06595 MidostaurinDrugbanksmall molecule
DB06603 PanobinostatDrugbanksmall molecule
DB06608 TafenoquineSwissprotsmall molecule
DB06654 SafinamideDrugbanksmall molecule
DB06678 EsmirtazapineDrugbanksmall molecule
DB06684 VilazodoneDrugbanksmall molecule
DB06691 MepyramineDrugbanksmall molecule
DB06700 DesvenlafaxineDrugbanksmall molecule
DB06702 FesoterodineDrugbanksmall molecule
DB06708 LumefantrineSwissprotsmall molecule
DB06726 BufuralolDrugbanksmall molecule
DB06727 SparteineSwissprotsmall molecule
DB06729 SulfaphenazoleDrugbanksmall molecule
DB06735 EnclomipheneSwissprotsmall molecule
DB06770 Benzyl alcoholSwissprotsmall molecule
DB06819 Phenylbutyric acidDrugbanksmall molecule
DB06820 SulconazoleSwissprotsmall molecule
DB08807 BopindololDrugbanksmall molecule
DB08808 BupranololDrugbanksmall molecule
DB08864 RilpivirineDrugbanksmall molecule
DB08881 VemurafenibDrugbanksmall molecule
DB08893 MirabegronDrugbanksmall molecule
DB08901 PonatinibDrugbanksmall molecule
DB08909 Glycerol phenylbutyrateSwissprotsmall molecule
DB08918 LevomilnacipranDrugbanksmall molecule
DB08922 PerospironeDrugbanksmall molecule
DB08952 IndenololSwissprotsmall molecule
DB09013 BefunololDrugbanksmall molecule
DB09039 EliglustatDrugbanksmall molecule
DB09048 NetupitantDrugbanksmall molecule
DB09049 NaloxegolDrugbanksmall molecule
DB09053 IbrutinibDrugbanksmall molecule
DB09061 CannabidiolDrugbanksmall molecule
DB09065 CobicistatSwissprotsmall molecule
DB09068 VortioxetineDrugbanksmall molecule
DB09076 UmeclidiniumDrugbanksmall molecule
DB09078 LenvatinibDrugbanksmall molecule
DB09118 StiripentolDrugbanksmall molecule
DB09128 BrexpiprazoleDrugbanksmall molecule
DB09167 DosulepinDrugbanksmall molecule
DB09173 ButyrfentanylDrugbanksmall molecule
DB09183 DasabuvirDrugbanksmall molecule
DB09195 LorpiprazoleDrugbanksmall molecule
DB09204 ArotinololDrugbanksmall molecule
DB09224 MelperoneDrugbanksmall molecule
DB09238 ManidipineDrugbanksmall molecule
DB09241 Methylene blueDrugbanksmall molecule
DB09288 PropacetamolDrugbanksmall molecule
DB09291 RolapitantDrugbanksmall molecule
DB09351 LevobetaxololDrugbanksmall molecule
DB09555 Dexchlorpheniramine maleateDrugbanksmall molecule
DB09570 IxazomibSwissprotsmall molecule
DB11130 OpiumDrugbanksmall molecule
DB11586 AsunaprevirDrugbanksmall molecule
DB11614 RupatadineDrugbanksmall molecule
DB11633 IsavuconazoleDrugbanksmall molecule
DB11638 ArtenimolDrugbanksmall molecule
DB11642 PitolisantDrugbanksmall molecule
DB11672 CurcuminDrugbanksmall molecule
DB11718 EncorafenibDrugbanksmall molecule
DB11732 LasmiditanDrugbanksmall molecule
DB11757 IstradefyllineDrugbanksmall molecule
DB11770 TalinololSwissprotsmall molecule
DB11785 AnisodamineSwissprotsmall molecule
DB11837 OsilodrostatDrugbanksmall molecule
DB11855 RevefenacinDrugbanksmall molecule
DB11915 ValbenazineDrugbanksmall molecule
DB11963 DacomitinibDrugbanksmall molecule
DB11979 ElagolixDrugbanksmall molecule
DB11994 DiacereinDrugbanksmall molecule
DB12001 AbemaciclibDrugbanksmall molecule
DB12070 LetermovirDrugbanksmall molecule
DB12161 DeutetrabenazineDrugbanksmall molecule
DB12212 LandiololSwissprotsmall molecule
DB12245 TriclabendazoleDrugbanksmall molecule
DB12332 RucaparibDrugbanksmall molecule
DB12499 ClascoteroneDrugbanksmall molecule
DB12500 FedratinibDrugbanksmall molecule
DB12523 MizolastineSwissprotsmall molecule
DB12693 RitanserinDrugbanksmall molecule
DB12752 BucindololSwissprotsmall molecule
DB13139 LevosalbutamolDrugbanksmall molecule
DB13174 RheinDrugbanksmall molecule
DB13293 IpecacSwissprotsmall molecule
DB13443 EsatenololSwissprotsmall molecule
DB13508 CloranololSwissprotsmall molecule
DB13530 MepindololSwissprotsmall molecule
DB13609 UmifenovirSwissprotsmall molecule
DB13679 DexchlorpheniramineSwissprotsmall molecule
DB13757 EpanololSwissprotsmall molecule
DB13775 TertatololSwissprotsmall molecule
DB13874 EnasidenibDrugbanksmall molecule
DB13975 Black cohoshSwissprotbiotech
DB14009 Medical CannabisDrugbankbiotech
DB14010 5-methoxy-N,N-dimethyltryptamineDrugbanksmall molecule
DB14011 NabiximolsDrugbanksmall molecule
DB14025 ClinafloxacinSwissprotsmall molecule
DB14185 Aripiprazole lauroxilDrugbanksmall molecule
DB14635 Curcumin sulfateDrugbanksmall molecule
DB14761 RemdesivirDrugbanksmall molecule
DB14840 RipretinibDrugbanksmall molecule
DB14881 OliceridineDrugbanksmall molecule
DB15091 UpadacitinibDrugbanksmall molecule
DB15328 UbrogepantDrugbanksmall molecule
DB15444 ElexacaftorDrugbanksmall molecule
DB15822 PralsetinibDrugbanksmall molecule
DB15982 BerotralstatDrugbanksmall molecule

Interactions

4 interactions