Entity Details

Primary name TAU_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP10636
EntryNameTAU_HUMAN
FullNameMicrotubule-associated protein tau
TaxID9606
Evidenceevidence at protein level
Length758
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesMAPT

GO terms

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GOName
GO:0000226 microtubule cytoskeleton organization
GO:0001774 microglial cell activation
GO:0003677 DNA binding
GO:0003680 minor groove of adenine-thymine-rich DNA binding
GO:0003690 double-stranded DNA binding
GO:0003697 single-stranded DNA binding
GO:0003723 RNA binding
GO:0003779 actin binding
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005874 microtubule
GO:0005886 plasma membrane
GO:0006475 internal protein amino acid acetylation
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007267 cell-cell signaling
GO:0007416 synapse assembly
GO:0007611 learning or memory
GO:0007613 memory
GO:0008017 microtubule binding
GO:0010288 response to lead ion
GO:0010506 regulation of autophagy
GO:0010629 negative regulation of gene expression
GO:0010917 negative regulation of mitochondrial membrane potential
GO:0015630 microtubule cytoskeleton
GO:0016072 rRNA metabolic process
GO:0016607 nuclear speck
GO:0017124 SH3 domain binding
GO:0019896 axonal transport of mitochondrion
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0021954 central nervous system neuron development
GO:0030424 axon
GO:0030425 dendrite
GO:0030426 growth cone
GO:0030673 axolemma
GO:0030674 protein-macromolecule adaptor activity
GO:0031110 regulation of microtubule polymerization or depolymerization
GO:0031113 regulation of microtubule polymerization
GO:0031116 positive regulation of microtubule polymerization
GO:0031122 cytoplasmic microtubule organization
GO:0031175 neuron projection development
GO:0032930 positive regulation of superoxide anion generation
GO:0033044 regulation of chromosome organization
GO:0033673 negative regulation of kinase activity
GO:0034063 stress granule assembly
GO:0034185 apolipoprotein binding
GO:0034399 nuclear periphery
GO:0034452 dynactin binding
GO:0034605 cellular response to heat
GO:0034614 cellular response to reactive oxygen species
GO:0035091 phosphatidylinositol binding
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0036477 somatodendritic compartment
GO:0042802 identical protein binding
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043197 dendritic spine
GO:0043565 sequence-specific DNA binding
GO:0044297 cell body
GO:0044304 main axon
GO:0045121 membrane raft
GO:0045298 tubulin complex
GO:0045773 positive regulation of axon extension
GO:0046785 microtubule polymerization
GO:0048143 astrocyte activation
GO:0048167 regulation of synaptic plasticity
GO:0048312 intracellular distribution of mitochondria
GO:0048699 generation of neurons
GO:0050808 synapse organization
GO:0050848 regulation of calcium-mediated signaling
GO:0051087 chaperone binding
GO:0051258 protein polymerization
GO:0051260 protein homooligomerization
GO:0051721 protein phosphatase 2A binding
GO:0051879 Hsp90 protein binding
GO:0061564 axon development
GO:0070507 regulation of microtubule cytoskeleton organization
GO:0071813 lipoprotein particle binding
GO:0072386 plus-end-directed organelle transport along microtubule
GO:0090140 regulation of mitochondrial fission
GO:0090258 negative regulation of mitochondrial fission
GO:0097386 glial cell projection
GO:0097418 neurofibrillary tangle
GO:0097435 supramolecular fiber organization
GO:0098930 axonal transport
GO:0099077 histone-dependent DNA binding
GO:0099609 microtubule lateral binding
GO:1900034 regulation of cellular response to heat
GO:1900452 regulation of long-term synaptic depression
GO:1901216 positive regulation of neuron death
GO:1902474 positive regulation of protein localization to synapse
GO:1902936 phosphatidylinositol bisphosphate binding
GO:1902988 neurofibrillary tangle assembly
GO:1903748 negative regulation of establishment of protein localization to mitochondrion
GO:1903829 positive regulation of cellular protein localization
GO:1904115 axon cytoplasm
GO:1904428 negative regulation of tubulin deacetylation
GO:1905689 positive regulation of diacylglycerol kinase activity
GO:1990000 amyloid fibril formation
GO:1990090 cellular response to nerve growth factor stimulus
GO:1990416 cellular response to brain-derived neurotrophic factor stimulus
GO:2001020 regulation of response to DNA damage stimulus

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection
Cytoplasm
Secreted

Domains

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DomainNameCategoryType
IPR001084 Microtubule associated protein, tubulin-binding repeatRepeatRepeat
IPR002955 Microtubule-associated protein TauFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB00448 LansoprazoleDrugbanksmall molecule
DB00637 AstemizoleDrugbanksmall molecule
DB01229 PaclitaxelDrugbanksmall molecule
DB01248 DocetaxelDrugbanksmall molecule
DB14914 Flortaucipir F-18Drugbanksmall molecule

Interactions

202 interactions

InteractorPartnerSourcesPublicationsLink
TAU_HUMANAATF_HUMANBioGRID, HPRD, MINT14697667 details
TAU_HUMANPINL_HUMANMINT16024016 details
TAU_HUMANKS6B1_HUMANBioGRID, HPRD, MINT16364302 17512525 details
TAU_HUMANGSK3B_HUMANBioGRID, HPRD, IntAct, MINT10090741 11181841 12048243 12387894 12551948 14612456 15073173 15542598 16365045 16446437 16519508 17045592 17078951 17512525 18467332 19014373 19527721 21985244 22965877 24165324 7566346 9199504 9546672 9614189 9735171 9771888 9832145 details
TAU_HUMANCDK5_HUMANBioGRID, HPRD, MINT11181841 1181841 11943163 12387894 16262633 16519508 17045592 17078951 19527721 26268594 7566346 9199504 9353289 9565682 9614189 9735171 9771888 9832145 details
TAU_HUMANSGK1_HUMANBioGRID, MINT15650334 16982696 17512525 details
TAU_HUMANKS6A3_HUMANBioGRID, HPRD, MINT11181841 11311121 12387894 17512525 9353289 9546672 9832145 details
TAU_HUMANAKT1_HUMANBioGRID, DIP, MINT17512525 18292230 19014373 31358653 details
TAU_HUMANKS6A5_HUMANBioGRID, MINT17512525 details
TAU_HUMANKS6A1_HUMANBioGRID, MINT17512525 details
TAU_HUMANDCTN1_HUMANBioGRID, IntAct, MINT, UniProt17932487 26269332 26638075 32814053 34079125 details
TAU_HUMANCHIP_HUMANBioGRID, DIP, HPRD, IntAct14612456 14962978 15447663 16275660 17304350 18292230 20466727 23237806 23554879 23696636 31320752 32022419 32401531 details
TAU_HUMANGSK3A_HUMANBioGRID, DIP, HPRD, UniProt16446437 17045592 26618561 7706316 7931292 details
TAU_HUMANA4_HUMANBioGRID, DIP, IntAct11943163 16446437 21958963 32814053 details
TAU_HUMANTAU_HUMANBioGRID, DIP, HPRD, UniProt10391244 14697667 16446437 16735465 17535890 19654187 26269332 26436840 27070645 27460788 30158706 30274285 30894745 9353289 details
TAU_HUMANEAA2_HUMANBioGRID, MINT19527721 details
TAU_HUMANSRC_HUMANBioGRID, MINT16014719 16115884 18467332 9763511 details
TAU_HUMANFYN_HUMANBioGRID, HPRD, MINT, UniProt11826099 15356202 16014719 16115884 18467332 21269457 21692989 25156556 31201283 9763511 details
TAU_HUMAN1433Z_HUMANBioGRID, HPRD, IntAct, MINT, UniProt10840038 12551948 15650334 17317006 19138662 19647741 23962087 26269332 27548710 28575131 29659825 details
TAU_HUMANPASK_HUMANMINT21418524 details
TAU_HUMANSYUA_HUMANBioGRID, HPRD, IntAct, MINT10464279 15904919 17408955 21127069 21985244 32814053 details
TAU_HUMANHS71A_HUMANBioGRID, MINT, UniProt21985244 23271055 23554879 29764935 details
TAU_HUMANHS71B_HUMANBioGRID, MINT21985244 23271055 23554879 details
TAU_HUMANLRRK2_HUMANBioGRID, IntAct22303461 24113872 26268594 details
TAU_HUMANMARK2_HUMANBioGRID, IntAct, UniProt23001711 23666762 24251416 26269332 details
TAU_HUMANBIN1_HUMANBioGRID, IntAct, UniProt23399914 25051234 26395440 28755476 details
TAU_HUMANPDIA1_HUMANIntAct24098548 details
TAU_HUMANHS90B_HUMANIntAct, UniProt24581495 26269332 30382094 details
TAU_HUMANEGFR_HUMANBioGRID, IntAct24658140 25402006 31980649 details
TAU_HUMANMARK4_HUMANBioGRID, HPRD, IntAct14594945 23666762 details
TAU_HUMANMARK3_HUMANBioGRID, IntAct23666762 details
TAU_HUMANMARK1_HUMANBioGRID, HPRD, IntAct10090741 10737616 12387894 12435421 21985311 23666762 7706316 7931292 8631898 8999860 9614189 9735171 9771888 9832145 details
TAU_HUMANHSP7C_HUMANBioGRID, HPRD, IntAct, UniProt14612456 17954934 18500754 19654187 25864199 26269332 28514442 29764935 details
TAU_HUMANFKBP4_HUMANBioGRID, DIP20133804 details
TAU_HUMANSQSTM_HUMANBioGRID, DIP15953362 25686248 29507222 details
TAU_HUMANHTRA1_HUMANBioGRID, DIP22535953 26436840 details
TAU_HUMANAPOE_HUMANBioGRID, HPRD, IntAct, UniProt26402096 32814053 7566652 8620924 9147408 9512010 details
TAU_HUMAN1433S_HUMANUniProt26402096 28575131 details
TAU_HUMANMTAP2_HUMANBioGRID, UniProt26269332 8990203 details
TAU_HUMANCALM2_HUMANBioGRID, HPRD, UniProt2123288 21339331 26269332 details
TAU_HUMANTBB3_HUMANBioGRID, UniProt24251416 24905733 26269332 27070645 details
TAU_HUMAN1433E_HUMANBioGRID, UniProt26269332 28575131 29659825 details
TAU_HUMAN1433G_HUMANUniProt26269332 28575131 details
TAU_HUMANHS90A_HUMANBioGRID, UniProt20071522 25864199 26269332 27254664 27495389 30382094 details
TAU_HUMANTBA4A_HUMANBioGRID, HPRD, UniProt19681044 24251416 26269332 9922135 details
TAU_HUMANACTG_HUMANBioGRID, UniProt19895707 2115775 26269332 details
TAU_HUMANACTB_HUMANBioGRID, HPRD, UniProt19895707 21339331 26269332 6304075 details
TAU_HUMANCDK1_HUMANBioGRID, HPRD, UniProt1323485 26269332 9614189 details
TAU_HUMANTBA1A_HUMANBioGRID, UniProt21339331 22565157 30274285 details
TAU_HUMANPCNA_HUMANUniProt26030842 details
TAU_HUMANMSI1H_HUMANUniProt30367664 details
TAU_HUMANMSI2H_HUMANUniProt30367664 details
TAU_HUMANTBB5_HUMANUniProt30274285 details
TAU_HUMANFKBP5_HUMANBioGRID, UniProt20071522 30382094 details
TAU_HUMANVILL_HUMANIntAct32814053 details
TAU_HUMANCAN10_HUMANIntAct32814053 details
TAU_HUMANDDX21_HUMANIntAct32814053 details
TAU_HUMANDOCK2_HUMANIntAct32814053 details
TAU_HUMANZFHX2_HUMANIntAct32814053 details
TAU_HUMANPPL13_HUMANIntAct32814053 details
TAU_HUMANPRKN_HUMANBioGRID, IntAct14962978 18248624 31882005 32814053 details
TAU_HUMANPIN1_HUMANBioGRID, HPRD10391244 16365047 22235112 details
TAU_HUMANS100B_HUMANBioGRID, HPRD11264299 2833519 details
TAU_HUMANCALM1_HUMANBioGRID, HPRD2123288 26269332 details
TAU_HUMANCALM3_HUMANBioGRID, HPRD2123288 26269332 details
TAU_HUMANBAG1_HUMANBioGRID17954934 details
TAU_HUMANHDAC6_HUMANBioGRID18636984 23962722 28540657 details
TAU_HUMANOGT1_HUMANBioGRID, HPRD12911634 16434389 8910513 details
TAU_HUMANHSP74_HUMANBioGRID14962978 18500754 21985244 22343013 23271055 29274099 details
TAU_HUMANEP300_HUMANBioGRID20869593 23962722 29734651 details
TAU_HUMANSIR1_HUMANBioGRID20869593 details
TAU_HUMANUB2D2_HUMANBioGRID14612456 details
TAU_HUMANKC1A_HUMANBioGRID7532213 9771888 details
TAU_HUMANKAPCA_HUMANBioGRID10090741 10840038 12435421 17045592 19014373 21127069 23962722 9546672 9771888 details
TAU_HUMANABL1_HUMANBioGRID, HPRD16014719 18070606 details
TAU_HUMANKSYK_HUMANBioGRID18070606 details
TAU_HUMANCSK21_HUMANBioGRID15882073 details
TAU_HUMANKC1D_HUMANBioGRID14761950 16618118 17101137 19014373 details
TAU_HUMANFAK2_HUMANBioGRID17512525 details
TAU_HUMANKCC2A_HUMANBioGRID17045592 17512525 details
TAU_HUMANPKN1_HUMANBioGRID, HPRD11104762 12387894 12435421 9199504 9546672 9832145 details
TAU_HUMANPTPA_HUMANBioGRID12435421 14612456 22235112 details
TAU_HUMANPPP5_HUMANBioGRID, HPRD12435421 1330687 15546861 16262633 details
TAU_HUMANCAN2_HUMANBioGRID14993287 details
TAU_HUMANMK13_HUMANBioGRID15632108 9199504 details
TAU_HUMANMK11_HUMANBioGRID15632108 9199504 details
TAU_HUMANMK08_HUMANBioGRID15228592 9199504 details
TAU_HUMANPEG10_HUMANBioGRID23666762 details
TAU_HUMANMARH7_HUMANBioGRID24905733 details
TAU_HUMANTBA1B_HUMANBioGRID16687396 24905733 details
TAU_HUMANCDK2_HUMANBioGRID19014373 details
TAU_HUMANTRAF6_HUMANBioGRID15953362 details
TAU_HUMANUBE2W_HUMANBioGRID25436519 31518613 details
TAU_HUMANP85A_HUMANBioGRID18467332 19681044 details
TAU_HUMANPWP2_HUMANBioGRID30217970 details
TAU_HUMANBRSK1_HUMANBioGRID21985311 details
TAU_HUMANBRSK2_HUMANBioGRID21985311 details
TAU_HUMANSIK1_HUMANBioGRID21985311 details
TAU_HUMANMELK_HUMANBioGRID21985311 details
TAU_HUMANTTBK1_HUMANBioGRID16923168 details
TAU_HUMANMK03_HUMANBioGRID10090741 9614189 details
TAU_HUMANMP2K7_HUMANBioGRID9614189 details
TAU_HUMANMK01_HUMANBioGRID9614189 details
TAU_HUMANCHK1_HUMANBioGRID20159774 details
TAU_HUMANCHK2_HUMANBioGRID20159774 details
TAU_HUMANMK09_HUMANBioGRID15228592 17906291 details
TAU_HUMANDYR1A_HUMANBioGRID11311121 17906291 details
TAU_HUMANDYRK2_HUMANBioGRID11311121 details
TAU_HUMANPP2AA_HUMANBioGRID, HPRD12435421 1330687 16262633 7616230 details
TAU_HUMANPP2AB_HUMANBioGRID16262633 7616230 details
TAU_HUMANDUS1_HUMANBioGRID7616230 details
TAU_HUMANMK10_HUMANBioGRID15228592 details
TAU_HUMANMK12_HUMANBioGRID, HPRD11104762 11181841 12226093 12387894 1330687 15632108 7566346 9199504 9353289 9565682 9735171 9771888 9832145 details
TAU_HUMANMK14_HUMANBioGRID15632108 details
TAU_HUMANKPCA_HUMANBioGRID11104762 details
TAU_HUMANKPCB_HUMANBioGRID11104762 details
TAU_HUMANKPCE_HUMANBioGRID11104762 details
TAU_HUMANKPCG_HUMANBioGRID11104762 details
TAU_HUMANKPCI_HUMANBioGRID11104762 details
TAU_HUMANKPCZ_HUMANBioGRID11104762 details
TAU_HUMANAMPH_HUMANBioGRID23399914 details
TAU_HUMANCASP6_HUMANBioGRID, HPRD12888622 15356202 details
TAU_HUMANCASP1_HUMANBioGRID, HPRD12888622 details
TAU_HUMANCASP3_HUMANBioGRID, HPRD11162250 12888622 16606369 22535953 details
TAU_HUMANCASP7_HUMANBioGRID, HPRD12888622 details
TAU_HUMANCASP8_HUMANBioGRID, HPRD12888622 details
TAU_HUMANACTS_HUMANBioGRID19895707 details
TAU_HUMANMASP1_HUMANBioGRID8990203 details
TAU_HUMANSRPK2_HUMANBioGRID23197718 28826672 details
TAU_HUMANSRPK1_HUMANBioGRID23197718 details
TAU_HUMANLGMN_HUMANBioGRID25326800 28826672 details
TAU_HUMANPP1A_HUMANBioGRID16262633 21489990 details
TAU_HUMANPP1B_HUMANBioGRID16262633 details
TAU_HUMANPP1G_HUMANBioGRID16262633 details
TAU_HUMANLCK_HUMANBioGRID21269457 9763511 details
TAU_HUMANPLCG1_HUMANBioGRID18467332 9592050 details
TAU_HUMANOTUB1_HUMANBioGRID28083634 details
TAU_HUMANTIA1_HUMANBioGRID27160897 27460788 details
TAU_HUMANCBP_HUMANBioGRID27383765 details
TAU_HUMANTHRB_HUMANBioGRID15542598 details
TAU_HUMANCATD_HUMANBioGRID9349548 details
TAU_HUMANPSA_HUMANBioGRID17154549 details
TAU_HUMANCAN1_HUMANBioGRID22535953 details
TAU_HUMANGRB2_HUMANBioGRID18467332 details
TAU_HUMANPACN1_HUMANBioGRID23035120 details
TAU_HUMANHOOK3_HUMANBioGRID25799409 details
TAU_HUMANHSPB1_HUMANBioGRID30385828 details
TAU_HUMANPDIA2_HUMANBioGRID24098548 details
TAU_HUMANFKB1A_HUMANBioGRID30382094 details
TAU_HUMANPTN11_HUMANBioGRID31201283 details
TAU_HUMANUB2D3_HUMANBioGRID32401531 details
TAU_HUMANARH40_HUMANHPRD16143467 details
TAU_HUMANSTAU1_HUMANBioGRID, HPRD, IntAct, UniProt15121898 26269332 details
TAU_HUMAN1433T_HUMANBioGRID, IntAct, MINT, UniProt15650334 26269332 31413325 details
TAU_HUMANPRIO_HUMANIntAct24028865 details
TAU_HUMANTTLL6_HUMANMINT24065130 details
TAU_HUMANRL28_HUMANUniProt26269332 26402096 details
TAU_HUMAN1433B_HUMANBioGRID, HPRD, UniProt10840038 12176984 26269332 26402096 details
TAU_HUMANDDX6_HUMANBioGRID, UniProt26269332 29966762 details
TAU_HUMANBIP_HUMANBioGRID, UniProt22460328 26269332 details
TAU_HUMANPSMD2_HUMANMINT, UniProt26269332 32357304 details
TAU_HUMANDNJA1_HUMANBioGRID, UniProt22343013 26269332 details
TAU_HUMANPRS7_HUMANBioGRID, UniProt15953362 26269332 details
TAU_HUMANANXA2_HUMANUniProt21339331 29636414 details
TAU_HUMANANXA6_HUMANUniProt29636414 details
TAU_HUMANMARE3_HUMANBioGRID, UniProt30668577 34079125 details
TAU_HUMANRANB9_HUMANIntAct31413325 details
TAU_HUMANCSN5_HUMANIntAct31413325 details
TAU_HUMANSYNE2_HUMANIntAct31413325 details
TAU_HUMANPAX6_HUMANIntAct31413325 details
TAU_HUMANS10AA_HUMANIntAct31413325 details
TAU_HUMANRU17_HUMANBioGRID, IntAct29802200 31413325 details
TAU_HUMANNPTX1_HUMANMINT32357304 details
TAU_HUMANBAIP2_HUMANMINT32357304 details
TAU_HUMANG37L1_HUMANMINT32357304 details
TAU_HUMANRAN_HUMANMINT32357304 details
TAU_HUMANSTXB1_HUMANBioGRID, HPRD12963086 details
TAU_HUMANPSN1_HUMANBioGRID, HPRD9689133 details
TAU_HUMANNUB1_HUMANBioGRID22965877 details
TAU_HUMANLIMS1_HUMANBioGRID23554879 details
TAU_HUMANUBC_HUMANBioGRID1723470 details
TAU_HUMANSMAD2_HUMANBioGRID24964035 details
TAU_HUMANPLCG2_HUMANBioGRID9592050 details
TAU_HUMANAHSA1_HUMANBioGRID20071522 details
TAU_HUMANTEBP_HUMANBioGRID20071522 details
TAU_HUMANCLUS_HUMANBioGRID25051234 details
TAU_HUMANCDC37_HUMANBioGRID21367866 details
TAU_HUMANHGS_HUMANBioGRID30166454 details
TAU_HUMANNMNA2_HUMANBioGRID27254664 details
TAU_HUMANJIP1_HUMANBioGRID19491104 details
TAU_HUMANADT1_HUMANBioGRID21958963 details
TAU_HUMANTOM20_HUMANBioGRID21958963 details
TAU_HUMANPPID_HUMANBioGRID21958963 details
TAU_HUMANSCRN1_HUMANBioGRID31796108 details
TAU_HUMANBRCA1_HUMANBioGRID31750914 details
TAU_HUMANUBB_HUMANHPRD14612456 details
TAU_HUMANPHKG1_HUMANHPRD10090741 10737616 12387894 7706316 8999860 9735171 9771888 9832145 details
TAU_HUMANKPCD_HUMANHPRD10090741 10737616 12387894 12435421 7706316 8999860 9735171 9771888 9832145 details
TAU_HUMANSPTB1_HUMANHPRD6743699 details
TAU_HUMANTBB2A_HUMANHPRD9922135 details
TAU_HUMANUSP9Y_HUMANHPRD1723470 details
TAU_HUMAN2A5A_HUMANHPRD12435421 details