Entity Details

Primary name BCR_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP11274
EntryNameBCR_HUMAN
FullNameBreakpoint cluster region protein
TaxID9606
Evidenceevidence at protein level
Length1271
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesBCR

GO terms

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GOName
GO:0004674 protein serine/threonine kinase activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005096 GTPase activator activity
GO:0005524 ATP binding
GO:0005829 cytosol
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0016020 membrane
GO:0019899 enzyme binding
GO:0030216 keratinocyte differentiation
GO:0030424 axon
GO:0032991 protein-containing complex
GO:0035023 regulation of Rho protein signal transduction
GO:0043197 dendritic spine
GO:0046777 protein autophosphorylation
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0048041 focal adhesion assembly
GO:0050804 modulation of chemical synaptic transmission
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0070062 extracellular exosome
GO:0090630 activation of GTPase activity
GO:0098685 Schaffer collateral - CA1 synapse
GO:0098978 glutamatergic synapse
GO:0099092 postsynaptic density, intracellular component
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity

Subcellular Location

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Subcellular Location
Cell junction
Cell projection

Domains

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DomainNameCategoryType
IPR000008 C2 domainDomainDomain
IPR000198 Rho GTPase-activating protein domainDomainDomain
IPR000219 Dbl homology (DH) domainDomainDomain
IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved siteSiteConserved site
IPR001849 Pleckstrin homology domainDomainDomain
IPR008936 Rho GTPase activation proteinFamilyHomologous superfamily
IPR015123 Bcr-Abl oncoprotein oligomerisationDomainDomain
IPR035892 C2 domain superfamilyFamilyHomologous superfamily
IPR035899 Dbl homology (DH) domain superfamilyFamilyHomologous superfamily
IPR036481 Bcr-Abl oncoprotein oligomerisation domain superfamilyFamilyHomologous superfamily
IPR037769 Abr/BcrFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB00619 ImatinibDrugbanksmall molecule
DB01254 DasatinibDrugbanksmall molecule
DB06616 BosutinibDrugbanksmall molecule
DB08901 PonatinibDrugbanksmall molecule

Interactions

89 interactions

InteractorPartnerSourcesPublicationsLink
BCR_HUMANGRB2_HUMANBioGRID, HPRD, IntAct, MINT10887132 11726515 14725908 15143164 19380743 21706016 28514442 32203420 7529874 8112292 8955135 8995379 9174058 9178913 details
BCR_HUMANP53_HUMANBioGRID, HPRD, IntAct16169070 25241761 details
BCR_HUMANU119A_HUMANBioGRID, HPRD, IntAct16169070 details
BCR_HUMANIGS21_HUMANBioGRID, HPRD, IntAct16169070 details
BCR_HUMANAPBA3_HUMANHPRD, MINT15494376 details
BCR_HUMANZO2_HUMANMINT15494376 details
BCR_HUMANGIPC1_HUMANMINT15494376 details
BCR_HUMANRGS12_HUMANMINT15494376 details
BCR_HUMANAFAD_HUMANBioGRID, MINT12808105 17491594 34079125 details
BCR_HUMANPTN1_HUMANHPRD, MINT9566916 details
BCR_HUMANTNKS2_HUMANIntAct22153077 details
BCR_HUMANERCC3_HUMANBioGRID, HPRD, IntAct10403766 17643375 28514442 9874796 details
BCR_HUMANFES_HUMANBioGRID, HPRD10706130 7529874 8955135 details
BCR_HUMANABL1_HUMANBioGRID, HPRD11780146 12543778 1712671 21653319 8112292 details
BCR_HUMANCRKL_HUMANBioGRID, HPRD10194128 15143164 8978305 details
BCR_HUMANRAC1_HUMANBioGRID9535855 details
BCR_HUMANCDC42_HUMANBioGRID9535855 details
BCR_HUMANRHOA_HUMANBioGRID9535855 details
BCR_HUMANTS101_HUMANBioGRID16778200 details
BCR_HUMANHSP7C_HUMANBioGRID20675402 details
BCR_HUMANCRK_HUMANBioGRID, HPRD19380743 8943292 8978305 details
BCR_HUMANCBL_HUMANBioGRID14725908 19380743 20675402 8621719 details
BCR_HUMANLNX1_HUMANBioGRID22889411 details
BCR_HUMANERBIN_HUMANBioGRID15123239 details
BCR_HUMANDOK1_HUMANBioGRID9822717 details
BCR_HUMANUBC_HUMANBioGRID23950177 details
BCR_HUMANCHIP_HUMANBioGRID20675402 details
BCR_HUMANP85A_HUMANBioGRID18346204 8781408 details
BCR_HUMANRAD51_HUMANBioGRID21653319 details
BCR_HUMANVAV_HUMANHPRD11790798 details
BCR_HUMANNHRF3_HUMANBioGRID, MINT15494376 28514442 details
BCR_HUMANCFTR_HUMANBioGRID, IntAct, MINT15494376 17110338 details
BCR_HUMANCLH1_HUMANMINT15494376 details
BCR_HUMANCOPB_HUMANMINT15494376 details
BCR_HUMANAT2B1_HUMANMINT15494376 details
BCR_HUMANTCF7_HUMANMINT16442529 details
BCR_HUMANGRAP_HUMANMINT8995379 details
BCR_HUMANKIT_HUMANBioGRID, IntAct25241761 8757502 details
BCR_HUMANPK3CG_HUMANBioGRID, IntAct25241761 7606002 details
BCR_HUMANJIP4_HUMANBioGRID, IntAct27173435 unassigned1312 details
BCR_HUMANWEE1_HUMANBioGRID, IntAct27173435 unassigned1312 details
BCR_HUMANMCM4_HUMANBioGRID, IntAct27173435 unassigned1312 details
BCR_HUMANKC1A_HUMANBioGRID, IntAct27173435 unassigned1312 details
BCR_HUMANMCM2_HUMANBioGRID, IntAct27173435 unassigned1312 details
BCR_HUMANMCM6_HUMANBioGRID, IntAct27173435 unassigned1312 details
BCR_HUMANUBP15_HUMANBioGRID, IntAct27173435 unassigned1312 details
BCR_HUMANSH2D5_HUMANIntAct25331951 details
BCR_HUMANTULP3_HUMANBioGRID, IntAct28514442 33187986 details
BCR_HUMAN1433B_HUMANHPRD, IntAct16045749 28514442 details
BCR_HUMAN1433G_HUMANHPRD, IntAct16045749 28514442 details
BCR_HUMAN1433F_HUMANHPRD, IntAct16045749 28514442 details
BCR_HUMANARG39_HUMANBioGRID, IntAct32203420 details
BCR_HUMANHCK_HUMANBioGRID, HPRD10849448 12522270 12592324 8955135 9178913 9407116 details
BCR_HUMANPTN6_HUMANBioGRID, HPRD27432908 9211920 9788431 details
BCR_HUMANRB_HUMANBioGRID9071815 details
BCR_HUMANGAB2_HUMANBioGRID15143164 details
BCR_HUMANSOS1_HUMANBioGRID7529874 8112292 details
BCR_HUMANPAXI_HUMANBioGRID7534286 details
BCR_HUMANIL3_HUMANBioGRID9209414 details
BCR_HUMANVPS28_HUMANBioGRID16778200 details
BCR_HUMANSHIP1_HUMANBioGRID20304029 details
BCR_HUMANHS90A_HUMANBioGRID16723087 20675402 21248063 details
BCR_HUMANHIF1A_HUMANBioGRID21124777 details
BCR_HUMANGBRR1_HUMANBioGRID16999686 details
BCR_HUMANSHC1_HUMANBioGRID, HPRD19380743 9209414 details
BCR_HUMANTEBP_HUMANBioGRID16723087 details
BCR_HUMANHSP74_HUMANBioGRID16723087 details
BCR_HUMANCH60_HUMANBioGRID16723087 details
BCR_HUMANSCAI_HUMANBioGRID28700933 details
BCR_HUMANSMAG2_HUMANBioGRID29395067 details
BCR_HUMANEST1A_HUMANBioGRID29395067 details
BCR_HUMANUBP1_HUMANBioGRID32602291 details
BCR_HUMAN1433S_HUMANHPRD16045749 details
BCR_HUMAN1433E_HUMANHPRD16045749 details
BCR_HUMANABL2_HUMANHPRD1383690 details
BCR_HUMANPLCG1_HUMANHPRD1383690 details
BCR_HUMANRASA1_HUMANHPRD1383690 details
BCR_HUMANBCR_HUMANHPRD11780146 details
BCR_HUMANIRS1_HUMANHPRD12560071 details
BCR_HUMANSRC_HUMANHPRD1383690 details
BCR_HUMAN1433T_HUMANHPRD16045749 details
BCR_HUMANDLG1_HUMANHPRD16825666 details
BCR_HUMANHNF1A_HUMANHPRD16442529 details
BCR_HUMANJAK2_HUMANHPRD12023981 12370803 details
BCR_HUMANPTN11_HUMANHPRD12115002 details
BCR_HUMANBLK_HUMANHPRD8756631 details
BCR_HUMAN1433Z_HUMANHPRD16045749 7939633 details
BCR_HUMANGRB10_HUMANHPRD9747873 details
BCR_HUMANM4K5_HUMANHPRD9949177 details