Entity Details

Primary name TOP1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP11387
EntryNameTOP1_HUMAN
FullNameDNA topoisomerase 1
TaxID9606
Evidenceevidence at protein level
Length765
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesTOP1

GO terms

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GOName
GO:0000932 P-body
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001650 fibrillar center
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0003697 single-stranded DNA binding
GO:0003723 RNA binding
GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0006260 DNA replication
GO:0006265 DNA topological change
GO:0006338 chromatin remodeling
GO:0007059 chromosome segregation
GO:0007623 circadian rhythm
GO:0012501 programmed cell death
GO:0016032 viral process
GO:0016310 phosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0019904 protein domain specific binding
GO:0032922 circadian regulation of gene expression
GO:0032993 protein-DNA complex
GO:0040016 embryonic cleavage
GO:0042493 response to drug
GO:0043204 perikaryon
GO:0097100 supercoiled DNA binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001631 DNA topoisomerase IFamilyFamily
IPR008336 DNA topoisomerase I, DNA binding, eukaryotic-typeDomainDomain
IPR011010 DNA breaking-rejoining enzyme, catalytic coreFamilyHomologous superfamily
IPR013030 DNA topoisomerase I, DNA binding, N-terminal domain 2FamilyHomologous superfamily
IPR013034 DNA topoisomerase I, DNA binding, N-terminal domain 1FamilyHomologous superfamily
IPR013499 DNA topoisomerase I, eukaryotic-typeDomainDomain
IPR013500 DNA topoisomerase I, catalytic core, eukaryotic-typeDomainDomain
IPR014711 DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-typeFamilyHomologous superfamily
IPR014727 DNA topoisomerase I, catalytic core, alpha/beta subdomainFamilyHomologous superfamily
IPR018521 DNA topoisomerase I, active siteSiteActive site
IPR025834 Topoisomerase I C-terminal domainDomainDomain
IPR036202 DNA topoisomerase I, DNA binding, eukaryotic-type, N-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00762 IrinotecanDrugbanksmall molecule
DB01030 TopotecanDrugbanksmall molecule
DB04690 CamptothecinDrugbanksmall molecule
DB04882 EdotecarinDrugbanksmall molecule
DB04967 LucanthoneDrugbanksmall molecule
DB05129 ElsamitrucinDrugbanksmall molecule
DB05482 7-ethyl-10-hydroxycamptothecinDrugbanksmall molecule
DB05630 Sodium stibogluconateDrugbanksmall molecule
DB05806 CositecanDrugbanksmall molecule
DB06069 XMT-1001Drugbanksmall molecule
DB06159 RubitecanDrugbanksmall molecule
DB07354 2,3-DIMETHOXY-12H-[1,3]DIOXOLO[5,6]INDENO[1,2-C]ISOQUINOLIN-6-IUMDrugbanksmall molecule
DB08159 4-(5,11-DIOXO-5H-INDENO[1,2-C]ISOQUINOLIN-6(11H)-YL)BUTANOATEDrugbanksmall molecule
DB11254 HexylresorcinolDrugbanksmall molecule
DB12893 Sacituzumab govitecanDrugbankbiotech
DB14962 Trastuzumab deruxtecanDrugbankbiotech

Interactions

87 interactions

InteractorPartnerSourcesPublicationsLink
TOP1_HUMANNUCL_HUMANBioGRID, HPRD, IntAct, MINT10967121 15848144 8567649 9512561 details
TOP1_HUMANSRSF1_HUMANBioGRID, HPRD, IntAct12270705 15848144 20805487 8639538 9611241 details
TOP1_HUMANPRKDC_HUMANBioGRID, IntAct15848144 28415827 details
TOP1_HUMANPARP1_HUMANBioGRID, IntAct15247263 15848144 34079125 details
TOP1_HUMANSF3B1_HUMANBioGRID, IntAct12549820 15848144 details
TOP1_HUMANNKX31_HUMANBioGRID, DIP, IntAct17234752 27339988 details
TOP1_HUMANABL1_HUMANMINT15448168 details
TOP1_HUMANXRCC5_HUMANBioGRID, Molecular Connections21679440 28415827 details
TOP1_HUMANCSK21_HUMANBioGRID, HPRD2998765 details
TOP1_HUMANCSK22_HUMANBioGRID2998765 details
TOP1_HUMANP53_HUMANBioGRID, HPRD10468612 11805286 18697815 32807901 8639538 details
TOP1_HUMANBTBD1_HUMANBioGRID, HPRD11818025 21092135 details
TOP1_HUMANBTBD2_HUMANBioGRID, HPRD11818025 21092135 details
TOP1_HUMANTOPRS_HUMANBioGRID, HPRD10352183 17976381 20805487 details
TOP1_HUMANUBC9_HUMANBioGRID, HPRD10759568 details
TOP1_HUMANCDT1_HUMANBioGRID18162579 details
TOP1_HUMANDDB2_HUMANBioGRID12549820 details
TOP1_HUMANERCC8_HUMANBioGRID12549820 details
TOP1_HUMANATM_HUMANBioGRID12549820 details
TOP1_HUMANIRF4_HUMANBioGRID12549820 details
TOP1_HUMANBARD1_HUMANBioGRID12549820 details
TOP1_HUMANELK3_HUMANBioGRID12549820 details
TOP1_HUMANTRBP2_HUMANBioGRID12549820 details
TOP1_HUMANKMT2A_HUMANBioGRID12549820 details
TOP1_HUMANIRF8_HUMANBioGRID12549820 details
TOP1_HUMANIRF9_HUMANBioGRID12549820 details
TOP1_HUMANSNW1_HUMANBioGRID12549820 details
TOP1_HUMANPRP1_HUMANBioGRID12549820 details
TOP1_HUMANRU17_HUMANBioGRID12549820 29802200 details
TOP1_HUMANU2AF2_HUMANBioGRID12549820 details
TOP1_HUMANLSM4_HUMANBioGRID12549820 details
TOP1_HUMANGEMI4_HUMANBioGRID12549820 details
TOP1_HUMANCDK8_HUMANBioGRID12549820 details
TOP1_HUMANBUB3_HUMANBioGRID12549820 details
TOP1_HUMANRBL1_HUMANBioGRID12549820 details
TOP1_HUMANRBL2_HUMANBioGRID12549820 details
TOP1_HUMANGRWD1_HUMANBioGRID12549820 29991511 details
TOP1_HUMANSYMPK_HUMANBioGRID12549820 details
TOP1_HUMANJAK1_HUMANBioGRID12549820 details
TOP1_HUMANDNLI4_HUMANBioGRID12549820 details
TOP1_HUMAN2ABB_HUMANBioGRID12549820 details
TOP1_HUMANTRI32_HUMANBioGRID12549820 details
TOP1_HUMANRECO_HUMANBioGRID12549820 details
TOP1_HUMANPYGM_HUMANBioGRID12549820 details
TOP1_HUMANAPAF_HUMANBioGRID12549820 details
TOP1_HUMANCKAP5_HUMANBioGRID12549820 details
TOP1_HUMANTBD_HUMANBioGRID12549820 details
TOP1_HUMANPDE10_HUMANBioGRID12549820 details
TOP1_HUMANA4_HUMANBioGRID21832049 details
TOP1_HUMANERG_HUMANBioGRID24591637 details
TOP1_HUMANMDM2_HUMANBioGRID24147044 24583282 details
TOP1_HUMANFSHR_HUMANBioGRID, HPRD15196694 details
TOP1_HUMANSRPK2_HUMANBioGRID26167880 details
TOP1_HUMANBRCA1_HUMANBioGRID28415827 details
TOP1_HUMANXRCC6_HUMANBioGRID28415827 30585729 details
TOP1_HUMANBRD2_HUMANBioGRID31753913 details
TOP1_HUMANSFPQ_HUMANBioGRID, HPRD, IntAct15848144 24981860 9756848 details
TOP1_HUMANTOPB1_HUMANMINT17006541 details
TOP1_HUMANMYC_HUMANBioGRID, IntAct17314511 20195357 29467282 30415952 details
TOP1_HUMANSMAD2_HUMANIntAct20195357 details
TOP1_HUMANJUN_HUMANHPRD, MINT15923621 25609649 details
TOP1_HUMANH31_HUMANBioGRID, IntAct20504901 29568061 34079125 details
TOP1_HUMANTAL1_HUMANBioGRID16407974 details
TOP1_HUMANSRS11_HUMANBioGRID, HPRD22939629 9756848 details
TOP1_HUMANCDN2A_HUMANBioGRID12673200 15361825 18004878 details
TOP1_HUMANARF_HUMANBioGRID12673200 15361825 18004878 details
TOP1_HUMANH2AY_HUMANBioGRID17158748 details
TOP1_HUMANPMS1_HUMANBioGRID17148452 details
TOP1_HUMANMGMT_HUMANBioGRID16226712 details
TOP1_HUMANH33_HUMANBioGRID20504901 details
TOP1_HUMANHDAC5_HUMANBioGRID21081666 details
TOP1_HUMANNOP56_HUMANBioGRID12777385 34079125 details
TOP1_HUMANSF3B3_HUMANBioGRID15848144 details
TOP1_HUMANPCNA_HUMANBioGRID11254741 details
TOP1_HUMANTF3C1_HUMANBioGRID9660958 details
TOP1_HUMANSEM1_HUMANBioGRID24515614 details
TOP1_HUMANSEML_HUMANBioGRID24515614 details
TOP1_HUMANPESC_HUMANBioGRID25825154 details
TOP1_HUMANGCR_HUMANBioGRID28611094 details
TOP1_HUMANERPG3_HUMANBioGRID26030138 details
TOP1_HUMANERCC6_HUMANBioGRID26030138 details
TOP1_HUMANTOP1_HUMANHPRD9756848 details
TOP1_HUMANCASP3_HUMANHPRD9933635 details
TOP1_HUMANCASP6_HUMANHPRD9933635 details
TOP1_HUMANSUMO1_HUMANHPRD11709553 12149243 12439742 details
TOP1_HUMANNCOA6_HUMANHPRD12519782 details
TOP1_HUMANTYDP1_HUMANHPRD12618186 details