Entity Details

Primary name FCGR1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP12314
EntryNameFCGR1_HUMAN
FullNameHigh affinity immunoglobulin gamma Fc receptor I
TaxID9606
Evidenceevidence at protein level
Length374
SequenceStatuscomplete
DateCreated1989-10-01
DateModified2021-06-02

Ontological Relatives

GenesFCGR1A

GO terms

Show/Hide Table
GOName
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0004888 transmembrane signaling receptor activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006898 receptor-mediated endocytosis
GO:0006911 phagocytosis, engulfment
GO:0006955 immune response
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0019864 IgG binding
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0031901 early endosome membrane
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0050776 regulation of immune response
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0061098 positive regulation of protein tyrosine kinase activity

Subcellular Location

Show/Hide Table
Subcellular Location
Cell membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR003598 Immunoglobulin subtype 2DomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR013151 ImmunoglobulinDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB00002 CetuximabDrugbankbiotech
DB00005 EtanerceptDrugbankbiotech
DB00028 Human immunoglobulin GDrugbankbiotech
DB00056 Gemtuzumab ozogamicinDrugbankbiotech
DB00087 AlemtuzumabDrugbankbiotech
DB00108 NatalizumabDrugbankbiotech
DB00110 PalivizumabDrugbankbiotech
DB00111 DaclizumabDrugbankbiotech
DB00112 BevacizumabDrugbankbiotech
DB00289 AtomoxetineDrugbanksmall molecule
DB00707 Porfimer sodiumDrugbanksmall molecule
DB06607 CatumaxomabDrugbankbiotech
DB11767 SarilumabDrugbankbiotech
DB14962 Trastuzumab deruxtecanDrugbankbiotech

Interactions

36 interactions

InteractorPartnerSourcesPublicationsLink
FCGR1_HUMANLCP2_HUMANMINT9716598 details
FCGR1_HUMANSHC1_HUMANMINT9716598 details
FCGR1_HUMANCBL_HUMANMINT9716598 details
FCGR1_HUMANBMP10_HUMANBioGRID, IntAct32296183 details
FCGR1_HUMANC163A_HUMANBioGRID, IntAct32296183 details
FCGR1_HUMANTNMD_HUMANBioGRID, IntAct32296183 details
FCGR1_HUMANRPRM_HUMANBioGRID, IntAct32296183 details
FCGR1_HUMANNRSN1_HUMANBioGRID, IntAct32296183 details
FCGR1_HUMANMALL_HUMANBioGRID, IntAct32296183 details
FCGR1_HUMANADIPO_HUMANBioGRID, IntAct32296183 details
FCGR1_HUMANASGR1_HUMANBioGRID, IntAct32296183 details
FCGR1_HUMANCLC7A_HUMANBioGRID, IntAct32296183 details
FCGR1_HUMANCLD19_HUMANBioGRID, IntAct32296183 details
FCGR1_HUMANLHPL5_HUMANBioGRID, IntAct32296183 details
FCGR1_HUMANFAM3C_HUMANBioGRID, IntAct32296183 details
FCGR1_HUMANBIK_HUMANBioGRID, IntAct32296183 details
FCGR1_HUMANUPK2_HUMANBioGRID, IntAct32296183 details
FCGR1_HUMANJAGN1_HUMANBioGRID, IntAct32296183 details
FCGR1_HUMANITM2A_HUMANBioGRID, IntAct32296183 details
FCGR1_HUMANTSPO2_HUMANBioGRID, IntAct32296183 details
FCGR1_HUMANVTI1B_HUMANBioGRID, IntAct32296183 details
FCGR1_HUMANNINJ1_HUMANBioGRID, IntAct32296183 details
FCGR1_HUMANVSTM1_HUMANBioGRID, IntAct32296183 details
FCGR1_HUMANIGHG1_HUMANUniProt25925696 details
FCGR1_HUMANFCERG_HUMANUniProt29143175 details
FCGR1_HUMANSAMP_HUMANBioGRID, HPRD11359830 details
FCGR1_HUMANKSYK_HUMANBioGRID, HPRD, IntAct11141335 25241761 details
FCGR1_HUMANFCG3A_HUMANBioGRID, HPRD, IntAct25241761 7516890 details
FCGR1_HUMANE41L2_HUMANUniProt22003208 details
FCGR1_HUMANCRKL_HUMANBioGRID, HPRD9820532 details
FCGR1_HUMANFCAR_HUMANBioGRID, HPRD12524384 16517729 8530370 details
FCGR1_HUMANHCK_HUMANBioGRID, HPRD8064233 details
FCGR1_HUMANLAT_HUMANBioGRID, HPRD10781611 details
FCGR1_HUMANCRP_HUMANHPRD12471137 details
FCGR1_HUMANHRG_HUMANHPRD10421785 details
FCGR1_HUMANFCGR1_HUMANHPRD9842885 details