Entity Details

Primary name IL7_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP13232
EntryNameIL7_HUMAN
FullNameInterleukin-7
TaxID9606
Evidenceevidence at protein level
Length177
SequenceStatuscomplete
DateCreated1990-01-01
DateModified2021-06-02

Ontological Relatives

GenesIL7

GO terms

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GOName
GO:0001961 positive regulation of cytokine-mediated signaling pathway
GO:0002360 T cell lineage commitment
GO:0005125 cytokine activity
GO:0005139 interleukin-7 receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0006959 humoral immune response
GO:0007267 cell-cell signaling
GO:0008083 growth factor activity
GO:0008284 positive regulation of cell population proliferation
GO:0009887 animal organ morphogenesis
GO:0019221 cytokine-mediated signaling pathway
GO:0030890 positive regulation of B cell proliferation
GO:0032722 positive regulation of chemokine production
GO:0038111 interleukin-7-mediated signaling pathway
GO:0043066 negative regulation of apoptotic process
GO:0043086 negative regulation of catalytic activity
GO:0045453 bone resorption
GO:0045579 positive regulation of B cell differentiation
GO:0045582 positive regulation of T cell differentiation
GO:0046622 positive regulation of organ growth
GO:0048873 homeostasis of number of cells within a tissue
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0062023 collagen-containing extracellular matrix
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR001181 Interleukin-7FamilyFamily
IPR018049 Interleukin-7/Interleukin-9, conserved siteSiteConserved site
IPR038325 Interleukin-7 superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
618309 OMIMEpidermodysplasia verruciformis 5 (EV5)A form of epidermodysplasia verruciformis, a rare genodermatosis associated with a high risk of skin carcinoma that results from an abnormal susceptibility to infection by specific human papillomaviruses, including the oncogenic HPV5. Infection leads to the early development of disseminated flat wart-like and pityriasis versicolor-like skin lesions. Cutaneous Bowen's carcinomas in situ and invasive squamous cell carcinomas develop in about half of the patients, mainly on sun-exposed skin areas. EV5 patients shows T-cell lymphopenia, particularly affecting CD4+ T cells. EV5 inheritance is autosomal recessive. The disease may be caused by variants affecting the gene represented in this entry.