Entity Details

Primary name CO6_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP13671
EntryNameCO6_HUMAN
FullNameComplement component C6
TaxID9606
Evidenceevidence at protein level
Length934
SequenceStatuscomplete
DateCreated1990-01-01
DateModified2021-06-02

Ontological Relatives

GenesC6

GO terms

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GOName
GO:0001701 in utero embryonic development
GO:0005576 extracellular region
GO:0005579 membrane attack complex
GO:0006956 complement activation
GO:0006958 complement activation, classical pathway
GO:0019835 cytolysis
GO:0030449 regulation of complement activation
GO:0045087 innate immune response
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000436 Sushi/SCR/CCP domainDomainDomain
IPR000884 Thrombospondin type-1 (TSP1) repeatRepeatRepeat
IPR001862 Membrane attack complex component/perforin/complement C9FamilyFamily
IPR002172 Low-density lipoprotein (LDL) receptor class A repeatRepeatRepeat
IPR002350 Kazal domainDomainDomain
IPR003884 Factor I / membrane attack complexDomainDomain
IPR020863 Membrane attack complex component/perforin domain, conserved siteSiteConserved site
IPR020864 Membrane attack complex component/perforin (MACPF) domainDomainDomain
IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved siteSiteConserved site
IPR035976 Sushi/SCR/CCP superfamilyFamilyHomologous superfamily
IPR036055 LDL receptor-like superfamilyFamilyHomologous superfamily
IPR036383 Thrombospondin type-1 (TSP1) repeat superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
612446 OMIMComplement component 6 deficiency (C6D)A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Disease susceptibility is associated with variants affecting the gene represented in this entry.