Entity Details

Primary name LIF_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP15018
EntryNameLIF_HUMAN
FullNameLeukemia inhibitory factor
TaxID9606
Evidenceevidence at protein level
Length202
SequenceStatuscomplete
DateCreated1990-04-01
DateModified2021-06-02

Ontological Relatives

GenesLIF

GO terms

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GOName
GO:0001974 blood vessel remodeling
GO:0005102 signaling receptor binding
GO:0005125 cytokine activity
GO:0005146 leukemia inhibitory factor receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005829 cytosol
GO:0006955 immune response
GO:0007260 tyrosine phosphorylation of STAT protein
GO:0007275 multicellular organism development
GO:0007566 embryo implantation
GO:0008083 growth factor activity
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0010628 positive regulation of gene expression
GO:0019221 cytokine-mediated signaling pathway
GO:0019827 stem cell population maintenance
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein
GO:0033630 positive regulation of cell adhesion mediated by integrin
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0043410 positive regulation of MAPK cascade
GO:0045595 regulation of cell differentiation
GO:0045651 positive regulation of macrophage differentiation
GO:0045835 negative regulation of meiotic nuclear division
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046697 decidualization
GO:0046888 negative regulation of hormone secretion
GO:0048286 lung alveolus development
GO:0048644 muscle organ morphogenesis
GO:0048666 neuron development
GO:0048711 positive regulation of astrocyte differentiation
GO:0048861 leukemia inhibitory factor signaling pathway
GO:0048863 stem cell differentiation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0060426 lung vasculature development
GO:0060463 lung lobe morphogenesis
GO:0060707 trophoblast giant cell differentiation
GO:0060708 spongiotrophoblast differentiation
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0072108 positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0072307 regulation of metanephric nephron tubule epithelial cell differentiation
GO:1900182 positive regulation of protein localization to nucleus
GO:1901676 positive regulation of histone H3-K27 acetylation
GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR001581 Leukemia inhibitory factor /oncostatinFamilyFamily
IPR003624 Leukemia inhibitory factorFamilyFamily
IPR009079 Four-helical cytokine-like, coreFamilyHomologous superfamily
IPR019827 Leukemia inhibitory factor /oncostatin, conserved siteSiteConserved site

Diseases

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Interactions

7 interactions