Entity Details

Primary name PGDH_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP15428
EntryNamePGDH_HUMAN
FullName15-hydroxyprostaglandin dehydrogenase [NAD(+)]
TaxID9606
Evidenceevidence at protein level
Length266
SequenceStatuscomplete
DateCreated1990-04-01
DateModified2021-06-02

Ontological Relatives

GenesHPGD

GO terms

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GOName
GO:0001822 kidney development
GO:0004957 prostaglandin E receptor activity
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006693 prostaglandin metabolic process
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007565 female pregnancy
GO:0007567 parturition
GO:0016323 basolateral plasma membrane
GO:0016404 15-hydroxyprostaglandin dehydrogenase (NAD+) activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0019372 lipoxygenase pathway
GO:0030728 ovulation
GO:0032355 response to estradiol
GO:0032496 response to lipopolysaccharide
GO:0042759 long-chain fatty acid biosynthetic process
GO:0042802 identical protein binding
GO:0043065 positive regulation of apoptotic process
GO:0045471 response to ethanol
GO:0045786 negative regulation of cell cycle
GO:0051287 NAD binding
GO:0070062 extracellular exosome
GO:0070403 NAD+ binding
GO:0070493 thrombin-activated receptor signaling pathway
GO:0097070 ductus arteriosus closure
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation
GO:1905828 regulation of prostaglandin catabolic process
GO:2001301 lipoxin biosynthetic process

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR002347 Short-chain dehydrogenase/reductase SDRFamilyFamily
IPR020904 Short-chain dehydrogenase/reductase, conserved siteSiteConserved site
IPR036291 NAD(P)-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00157 NADHDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
PGDH_HUMANA4_HUMANBioGRID21832049 details